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| Effects of Propofol Intravenous Anesthesia on Hemodynamic and Cytokines in Radical Resection of Lung Cancer |
| GE Li, ZHU Mei-hua |
| Department of Anesthesiology, Rugao People's Hospital of Jiangsu Province, Jiangsu Rugao 226500 |
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Abstract 【Objective】To investigate the anesthetic effect of total intravenous propofol anesthesia in radical resection of lung cancer and study its effect on serum cytokines. 【Methods】A total of 70 patients who underwent radical surgery for lung cancer were randomly divided into two group, with 35 cases in each group. The control group received sevoflurane inhalation anesthesia, while the observation group received propofol intravenous anesthesia. Hemodynamic parameters, serum cytokines and intraoperative anesthesia were compared between the two groups. 【Results】At the time of admission (T0), the difference of MAP, HR and SpO2 between the two group was not statistically significant (P>0.05). At the time of T1(start of ventilation),T2 (end of ventilation) and T3 (end of surgery), the measured values of MAP and HR in the control group were lower than those in the observation group (P<0.05). Levels of SpO2 from T1～T4 (extubation) were not significant differences between the two group (P>0.05). There were no significant differences in serum IL-6, IL-8 and IL-10 levels between two group before surgery (P>0.05). At 2h after operation, the serum levels of IL-6 and IL-8 in the observation group were lower (P<0.05) than those in the control group; While the serum IL-10 level at 2h after surgery in the observation group were higher than that in the control group (P<0.05). The anesthetic effects of the two groups was no significant difference (P>0.05). 【Conclusion】The effects of total intravenous propofol anesthesia on hemodynamic parameters and cytokine balance in patients undergoing radical resection of lung cancer are less than those of sevoflurane inhalation anesthesia.
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Received: 26 February 2019
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[1] 包娜日素, 韩亚升, 张生茂,等. 舒芬太尼复合丙泊酚靶控输注对肺癌根治术患者的麻醉效果及安全性[J].实用癌症杂志, 2017, 32(6):956-958.
[2] 仲吉英, 徐枫, 张涛,等. 七氟醚吸入麻醉和丙泊酚静脉麻醉对老年肺癌根治术患者血清VEGF、VCAM-1、MMP-2和MMP-9表达的影响[J].中华老年多器官疾病杂志, 2017, 16(2):106-109.
[3] 徐超,沈昀.丙泊酚、依托咪酯在卵巢癌全麻手术中的效果及对患者循环功能的影响[J].癌症进展,2018,16(3):349-352.
[4] Liu S, Sun JY, Ren LP,et al.Propofol attenuates intermittent hypoxia induced up-regulation of proinflammatory cytokines in microglia through inhibiting the activation of NF-κB/p38 MAPK signalling[J].Folia Neuropathol,2017, 2(2):124-131.
[5] 卢建华, 韦钰, 林颖,等. 七氟烷持续吸入麻醉对肺癌根治术后患者认知功能的影响研究[J].现代中西医结合杂志, 2017, 26(11):1232-1234.
[6] 钱志峰, 毛发江, 徐磊,等.右美托咪定联合地佐辛镇痛方案对腹腔镜胆囊切除术患者的镇痛、炎性细胞因子及术后认知功能的影响探究[J].东南国防医药, 2017, 19(2):187-189.
[7] 李刚. 不同麻醉方式对肺癌根治术患者血流动力学的影响分析[J].实用癌症杂志, 2016, 31(6):934-936.
[8] Li W, Wang X, Niu X, et al.Protective effects of nobiletin against endotoxic shock in mice through inhibiting TNF-α, IL-6, and HMGB1 and regulating NF-κB pathway[J].Inflammation,2016, 39(2):786-797.
[9] 金晓春, 张飞, 郑杰,等.丙泊酚静脉麻醉对结直肠癌根治术患者血液流变学、血流动力学及免疫功能的影响[J].海南医学院学报, 2018, 24(2):257-261. |
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2019, Vol. 36 
