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| Clinical Significance of Cystatin C, High-sensitive C reactive protein and Uric Acid in Cerebral Small Vessel Disease |
| WU Xian-chuan, WANG Yuan-qiao, LI Lin-min, et al |
| Dazhou Hospital of Integrated Traditional Chinese and Western Medicine: Department of Critical Care Medicine, Dazhou, Sichuan 635000 |
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Abstract 【Objective】To investigate the clinical significance of cystatin C (Cys-C),high-sensitive C reactive protein (hs-CRP) and uric acid (UA) in patients with cerebral small vessel disease (CSVD). 【Methods】A total of 98 patients with CSVD admitted to our hospital from August 2016 to August 2017 were selected as the observation group, while 98 volunteers with normal cerebrovascular examination in our hospital were selected as the control group. All patients underwent MRI examination. Levels of cystatin C, high-sensitive C reactive protein and uric acid in two groups were compared. The patients with CSVD were further divided into the cognitive impairment group (n=54) and normal cognition group (n=44) and levels of cystatin C, high-sensitive C reactive protein and uric acid between two groups were compared. Risk factors and correlation of cognitive impairment were analyzed by Logistic regression analysis and Pearson correlation analysis. 【Results】Levels of cystatin C, high-sensitive C reactive protein and uric acid in the observation group were higher than those in the control group; The differences were statistically significant (P＜0.05).The were no significantly differences of the levels of cystatin C and high-sensitive C reactive protein in the groups of cognitive impairment and normal cognition CSVD patients, however, the level of UA in the cognitive impairment group was higher than that in the cognitively normal group (P＜0.05).Uric acid was an independent risk factor for the occurrence of CSVD and it was negatively correlated with total score of MoCA, executive ability, language capacity and delayed recall. 【Conclusion】The levels of cystatin C, high sensitive C reactive protein and uric acid in the patients with CSVD were elevated. The level of uric acid was a risk factor for cognitive impairment.
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Received: 07 January 2019
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[1] Wardlaw JM,Smith C,Dichgans M.Mechanisms of sporadic cerebral small vessel disease:insights from neuroimaging[J].Lancet Neurol,2013,12(5):483-497.
[2] Thompson CS,Hakim AM. Living beyond our physiological means:small vessel disease of the brain is an expression of a systemic failure in arteriolar function:a unifying hypothesis[J].Stroke,2009,40:e322-e330.
[3] Cho SJ,Yu KH,Mi SO,et al. Post-stroke memory impairment among patients with vascular mild cognitive impairment[J].BMC Neurol,2014,14(1):1-6.
[4] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国脑小血管病诊治共识[J].中华神经科杂志, 2015, 48(10): 838-844.
[5] Horio M, Imai E, Yasuda Y, et al. GFR Estimation Using Standardized Serum Cystatin C in Japan [J].Am J Kidney Dis,2013, 61(2):197-203.
[6] Shi GP.Cystatin C deficiency in human atherosclerosis and aortic aneurysms[J].J Clin Invest,1999,104(9):1191-1197.
[7] 郭伟民,肖传实,申秀敏,等.太原市社区居民高尿酸血症患病率及其与高血压和高血糖及高血脂的关系[J].中国全科医学,2012,15(9):3405-3047.
[8] 尹占霞,赵丹如.血尿酸与急性脑梗死相关性研究-360例急性脑梗死患者相关因素分析[J].军事医学,2011,35:461-463.
[9] 李衍芳,高鸣,张志超,等.血尿酸与脑小血管病患者血管性轻度认知障碍的相关性研究[J].中国卒中杂志,2018,13(3):237-241.
[10] Ryu ES,Kmin MJ,Shin HS,et al. Uric acid induced phenotypic transition of renal tubular cells as a novel mechanism of chronic kidney disease[J].Am J Physiol Renal Physiol,2013,304(5):F471-F480.
[11] Verhaaren BF,Vernooij MW,Dehghan A,et al. The relation of uric acid to brain atrophy and cognition:the rotterdam scan study[J].Neuroepidemiology,2013,41(1):29-34.
[12] Vannorsdall TD,Jinnah HA,Gordon B,et al. Cerebral ischemia mediates the effect of serum uric acid on cognitive function[J].Stroke,2008,39(12):3418-3420. |
| [1] |
. [J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(1): 152-153. |
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2019, Vol. 36 
