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Quick Search     Adv Search 2019 Vol. 36, No. 1 Published: 2019-01-30   1 Clinical Effect of Comminuted Femoral Fractures Bridging Internal Fixation System for Distal Femoral Fractures TANG Yi-min, CUI Hai-yong DOI: 10.3969/j.issn.1671-7171.2019.01.001 【Objective】 To explore the clinical effect of comminuted femoral fractures bridging internal fixation system in the treatment of distal femur fracture. 【Methods】 From Jane 2015 to Jane 2017, 29 patients with distal femoral fracture were treated with bridging combined internal fixation system were selected as observation group and 30 patients with anatomical locking plate internal fixation as control group.The indexes of operation, postoperative indexes and the rate of limb function between the two groups were compared to evaluate the clinical effect of the two kinds of internal fixation.【Results】 The operative time and intraoperative bleeding in the observation group were significantly lower than those in the control group, and the time of fracture healing and hospitalization were significantly shorter in the observation group than in the control group (P<0.05). There were no postoperative complications in the observation group and one case in the control group.【Conclusion】 Comminuted femoral fractures bridging internal fixation system has the advantages of simple operation, flexible application, saving operation time, reducing intraoperative bleeding, shortening fracture healing time and hospitalization time, and high recovery rate of limb function, which is worthy of clinical application. 2019 Vol. 36 (1): 1-3 [Abstract] ( 418 ) HTML (1 KB)  PDF  (0 KB)  ( 16 ) 4 Clinical Effect of Compound Danshen(Salvia Miltiorrhiza) Pills in the Treatment of Diabetic Retinopathy ZHAO Chuan-qiao DOI: 10.3969/j.issn.1671-7171.2019.01.002 【Objective】 To investigate the clinical effect of compound salvia miltiorrhiza(Danshen) pills in the treatment of diabetic retinopathy(DR). 【Methods】 The clinical data of 106 patients with DR from March 2015 to October 2017 were divided into observation group and control group with 53 cases in each group. The patients in the control group were treated with hypoglycemic, acid-base balance, and the observation group was treated with compound salvia miltiorrhiza pills on the basis of the control group. The therapeutic effect, visual field grayscale, hemangioma volume, macular area, macular thickness, serum interleukin-6 (IL-6), tumor necrosis factor (TNF-α),high sensitivity C-reactive protein (hs-CRP), plasma endothelin-1 (ET-1), vascular endothelial growth factor (VEGF), reactive oxygen (ROS) were observed. The levels of superoxide dismutase (SOD) and malondialdehyde (MDA) (MDA) were measured by spectrophotometer.【Results】 The total effective rate was 90.57% (48 / 53) in the observation group and 77.36% (41/53) in the control group (P<0.05). The visual field grayscale, hemangioma volume, macular area, macular thickness, serum hs-CRP, IL-6,TNF-αand ET-1, VEGF, ROS, MDA levels were significantly lower in both groups than before treatment, and SOD was significantly higher than that before treatment. The improvement in the observation group was more significant than that in the control group, and the difference was statistically significant (P<0.05). There were no obvious adverse drug reactions in both groups during treatment.【Conclusion】 Compound salvia miltiorrhiza (Danshen) pills can improve the clinical efficacy, improve the symptoms of visual field defect, down-regulate the inflammatory index, improve vascular endothelial function, alleviate oxidative stress state, and the safety is good. It is worth popularizing in clinical application. 2019 Vol. 36 (1): 4-7 [Abstract] ( 330 ) HTML (1 KB)  PDF  (0 KB)  ( 17 ) 8 Correlation Analysis of Different Obesity Phenotype and Bone Metabolism Indexes in Young Males YIN Fu-zai, ZHANG Wei-nan, WU Guang fei, et al DOI: 10.3969/j.issn.1671-7171.2019.01.003 【Objective】 To investigate the correlation between different obesity phenotypes and bone metabolism in young male.【Methods】 136 young males were selected and divided into three groups according to different obesity phenotypes: normal metabolic health body mass index group(n=32,BMI<24 kg/m2 and no abnormal metabolic factors, group A), metabolic healthy obesity group (n=30,BMI≥28 kg/m2 and no abnormal metabolic factors, group B) and abnormal metabolic obesity group (n=74, BMI ≥ 28 kg/m2 and greater than or equal to 1 item of abnormal metabolism, group C).The blood glucose[fasting blood glucose (FPG), blood glucose (2hPG)], blood pressure[systolic blood pressure (SBP), diastolic blood pressure (DBP)], blood lipid[triglyceride], high-density lipoprotein cholesterol (HDL-C) and bone metabolism marker[bone calcium (OC)],serum total type 1 collagen-base-end extension peptide (P1NP), type 1 collagen-linked C-terminal peptide (CTX) level were measured and compared in each group.【Results】 The P1NP and OC of group C were significantly lower than those of group A and B (P<0.001), and the S-CTX of group A was significantly higher than that of group A (P<0.001).Correlation analysis between obese group B and group C showed that P1NP was negatively correlated with FPG (r=0.406), S-CTX was positively correlated with BMI (r=0.342) and, OC with FPG (r=0.365). There was a negative correlation between SBP (r=0.229,P=0.019), BMI (r=0.218,P=0.026), CTX (r=0.223), CTX (P=0.023). OC was a positive correlated with P1NP (r=0.245,P=0.012).Logistic regression analysis showed that the level of P1NPOC in group C was 4.198 times lower than that in group A (95% CI: 1.703~10.353,P=0.002) and 6.953 times of that in group, B (95% CI:2.513~17.297,P<0.001).The levels of CTX in group C and B were 11.25 times higher than those in group A (95% CI:3.854~32.837,P<0.001) and 7.062 times (95% CI:2.134~23.367,P<0.001).【Conclusion】 Different obesity phenotypes of young males have different bone metabolism indexes. When metabolic abnormality and obesity exist simultaneously, CTX level increases significantly, and P1NPOC level decrease, suggesting that OC index is closely related to metabolic index. 2019 Vol. 36 (1): 8-10 [Abstract] ( 236 ) HTML (1 KB)  PDF  (0 KB)  ( 16 ) 11 Effect of Bikalumide Combined with Goserelin in Patients with Advanced Prostate Cancer CHEN Xiang, WANG Wei, RAN Jun-wu, et al DOI: 10.3969/j.issn.1671-7171.2019.01.004 【Objective】 To investigate the efficacy of bikalumide in patients with advanced prostate cancer.【Methods】 A total of 92 patients with advanced prostate cancer admitted in our hospital from January 2016 to December 2017 were randomly divided into two groups, with 46 cases in each group. Patients in the control group received routine therapy with foserelin, while patients in the observation group was treated with bikalumide on the basis of foserelin routine treatment. The clinical efficacy and serum prostate specific antigen (PSA), vascular endothelial growth factor (VEGF), miRNA-34a (miR-34a), insulin-like growth factor-1 (IGF-1) levels and SMYD3 positive expression rate were compared before and after treatment. Quality of life measurement scale (QLQ-C30) score and patient satisfaction were evaluated as well.【Results】 The total effective rate of the observation group was 95.65% (44/46), which was significantly higher than that of the control group (80.43% (37/46)). The difference was statistically significant (P<0.05). There were no statistically significant differences between the two groups in the levels of PSA, VEGF, miR-34a,IGF-1, SMYD3 and QLQ-C30 before treatment (P>0.05). After treatment, the levels of PSA, VEGF, IGF- and SMYD3 in the observation group were lower than those in the control group, and the level of miR-34a and QLQ-C30 score were higher than those in the control group (P<0.05). The patient satisfaction in the observation group was 95.65%, which was significantly higher than that in the control group 54.35%, and the difference was statistically significant (P<0.05). 【Conclusion】 Bikalumide combined with goserelin have significant therapeutic effect in patients with advanced prostate cancer, which can reduce levels of PSA VEGF and IGF-1, increase miR-34a level, effectively control SMYD3 expression, improve the quality of life and enhance patient satisfaction. 2019 Vol. 36 (1): 11-14 [Abstract] ( 273 ) HTML (1 KB)  PDF  (0 KB)  ( 21 ) 15 Relationship between the Severity of Delayed Encephalopathy and the Degree of Myocardial Injury in Acute Carbon Monoxide Poisoning AN Lian-chao, WU Xiao-ning, LI Xiao-ti DOI: 10.3969/j.issn.1671-7171.2019.01.005 【Objective】 To investigate the changes and significance of myocardial enzymes in patients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP). 【Methods】 A total of 60 patients with acute carbon monoxide poisoning (ACMP) were enrolled in the study, including 33 patients with DEACMP ( group A) and 27 patients without DEACMP ( group B). Levels of serum myoglobin (Mb), troponin (cTnI), creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST) in the acute phase and DEACMP recovery period were detected and compared in the two groups.【Results】 The incidences of ST-T changes, atrioventricular block (I degree), and indoor block in group A were significantly higher than those in group B (P<0.05). There were no significant differences in QT interval prolongation, sinus bradycardia, atrial premature contraction, ventricular premature contraction, and atrial fibrillation rate between the two groups (P>0.05). In the acute phase, the of patients in A group serum Mb, cTnI, CK-MB and LDH levels in group A were significantly higher than those in group B (P<0.05). The levels of serum Mb, cTnI, CK-MB and LDH in the recovery of group A patients were significantly lower than those in the acute phase, the difference was statistically significant (P<0.05). 【Conclusion】 In the acute phase, the myocardial enzymology index of patients with DEACMP is significantly higher than that of patients with ACMP alone, and the abnormal rate of ECG monitoring results is increased. These indicators are helpful for early prediction and targeted treatment of DEACMP. 2019 Vol. 36 (1): 15-17 [Abstract] ( 221 ) HTML (1 KB)  PDF  (0 KB)  ( 19 ) 18 Dosimetric Characteristics and Efficacy of Volumetric Modulated Arc Therapy for Nasopharyngeal Carcinoma CHENG Mao-qiang, ZHOU Guang-yao, TANG Long DOI: 10.3969/j.issn.1671-7171.2019.01.006 【Objective】 To investigate the dosimetric characteristics and clinical efficacy of volumetric modulated arc therapy (VMAT) for nasopharyngeal carcinoma. 【Methods】 Total clinical data of 90 patients with nasopharyngeal carcinoma were collected. According to radiotherapy modes, they were divided into the VMAT (volumetric modulated arc therapy) group (n=50) and the sIMRT the (static intensity-modulated radiation therapy) group (n=40). Dosimetric evaluation was performed to compare the target coverage, homogeneity, conformity, efficacy and safety between the two groups. 【Results】 The PCTV (planned clinical target area) indicators: Dmin, D2, D98, Dmean and CI (conformality) in the VMAT group were higher than the sIMRT group, while HI (uniformity index) was lower than the sIMRT group (P<0.05). The PGTV (planned gross tumor target area) indicators: Dmax, Dmin, D2, Dmean and CI in the VMAT group were higher than the sIMRT group (P<0.05). In the VMAT group, Dmax and D1 of the brainstem were higher than those in the sIMRT group (P<0.05), the temporomandibular joint Dmax and laryngeal Dmean were higher than those in the sIMRT group (P<0.05), and the temporal lobe D1 was lower than that in the sIMRT group (P<0.05). The treatment monitor unit (MU) and treatment time of the VMAT group were lower than those of the sIMRT group (P<0.05). The total effective rate of treatment and the incidence of adverse reactions between the two groups were not significantly different (P>0.05). 【Conclusion】 The application of VMAT in patients with nasopharyngeal carcinoma can shorten the time of radiotherapy with high homogeneity and conformity. 2019 Vol. 36 (1): 18-20 [Abstract] ( 208 ) HTML (1 KB)  PDF  (0 KB)  ( 23 ) 21 Clinical Study on Intensity-modulated Radiation Therapy Combined with Acetylcysteine in Treating Non-small Cell Lung Cancer LU Xiu-rong, SONG Xiao, ZOU Nian-dong, et al DOI: 10.3969/j.issn.1671-7171.2019.01.007 【Objective】 To explore the clinical efficacy of intensity-modulated radiation therapy combined with acetylcysteine in the treatment of non-small cell lung cancer (NSCLC).【Methods】 In this study, a total of 80 patients with NSCLC admitted in our hospital from August 2014 to December 2015, were divided into two groups on the basis of random number table method, with 40 cases in each group. The control group was administrated with solely intensity-modulated radiation therapy, while the treatment group was administrated with intensity-modulated radiation therapy in combination with acetylcysteine. The incidence of radiation pneumonitis, changes of serum biological markers [glutathione (GSH), interleukin (IL) -6, transforming growth factor (TGF) -β, type II alveolar cell surface antigen (KL-6)], and Karnofsky performance status (KPS) scores at different time points before and after the therapy were compared between the two groups.【Results】 The incidence of radiation pneumonitis in the treatment group was 15.00% (6/40), which was significantly lower than that in the control group 40.00% (16/40)(P<0.05). The serum GSH levels in the observation group at the end of radiotherapy and 1 and 3 months after radiotherapy were significantly higher than those in the control group. The serum levels of IL-6, TGF-β and KL-6 were significantly lower than those in the control group (P<0.05). The KPS scores at the end of radiotherapy and 1 and 3 months after radiotherapy were significantly increased in the observation group compared with the control group (P<0.05).【Conclusion】 In the treatment of NSCLC, the combination of intensity modulated radiation therapy and acetylcysteine proves to be effective in preventing radiation pneumonitis, enhancing body's antioxidation capacity, reducing the irradiation-induced lung injury and improving life quality. 2019 Vol. 36 (1): 21-24 [Abstract] ( 178 ) HTML (1 KB)  PDF  (0 KB)  ( 18 ) 25 Effects of San Erkang Tablet Combined with Ovulation Stimulating Hormone Tablet on Endometrial Receptivity, Estrogen, Progesterone and Endometrial Blood Flow in Patients with Repeated Implantation Failure JIANG Yu-wei, PU Si-ying, PENG Ling-hua, et al DOI: 10.3969/j.issn.1671-7171.2019.01.008 【Objective】 To investigate the effects of San Erkang tablet combined with ovulation tablet on endometrial receptive morphology, endometrial blood flow, serum estrogen and progesterone in patients with repeated implantation failure. 【Methods】 A total of 100 patients (<40 years old) who failed implantation repeatedly were treated with oral San Erkang tablets combined with ovulation stimulating hormone tablets for three months. The endometrial receptivity was evaluated before and after treatment. The evaluation indicators included: vaginal ultrasound to assess endometrial thickness and arterial blood flow on day 6~9 after ovulation, serum estrogen and progesterone levels measured by chemiluminescence assay and pinocytosis (pinopodes) of endometrial cells evaluated by scanning electron microscope (SEM) after vaginal ultrasound assessment. 【Results】 After three months of combined therapy, the number of pinopodes was greater than that before treatment (P<0.05). After treatment, the fully developed pinocytosis increased and the developmental and regressive pinocytosis decreased. The difference was statistically significant (P<0.01). The level of estrogen and progesterone changed significantly after combined therapy (P<0.01). The thickness of endometrium was thicker than that before treatment (P<0. 05), and the PI and S / D values of uterine artery decreased (P<0. 05), but there was no significant difference in RI value. Compared to pre-treatment status, the estradiol (E2), uterine artery pulsatility index (PI) and the ratio of the maximum systolic velocity to the end-diastolic flow velocity (S/D) decreased. Meanwhile, the progesterone (P) and the thickness of the endometrium increased after treatment. The differences were statistically significant (P<0.05). The difference of the resistance index (RI) was not statistically significant. 【Conclusion】 San Erkang tablet combined with ovulation stimulating hormone tablet improves the degree and richness of pinopodes development, stimulates the secretion of estrogen and progesterone, enhances the blood supply of the endometrium, and promotes the implantation window of endometrial receptivity in patients with repeated implantation failure. 2019 Vol. 36 (1): 25-27 [Abstract] ( 154 ) HTML (1 KB)  PDF  (0 KB)  ( 19 ) 28 Clinical Significance of Serum Procalcitonin Dynamic Determination in Patients with Perforation Peritonitis in Gastrointestinal Surgery ZHOU Kui-ping, CHEN You Jiang, CHEN Wei, et al DOI: 10.3969/j.issn.1671-7171.2019.01.009 【Objective】 To investigate the clinical significance of serum procalcitonin dynamic determination in patients with perforated peritonitis in gastrointestinal surgery. 【Methods】 From November 2015 to November 2017, 88 cases of patients with gastrointestinal perforation were studied in our hospital. According to peritonitis, they were divided into infection group (32 cases) and non infection group (56), and 40 healthy persons were selected as normal control group. The serum levels of procalcitonin (PCT) were measured in all the patients, and the PCT levels in different groups were compared, and the clinical situation and prognosis of patients with different intestinal perforations were compared. 【Results】 The serum PCT levels in the non-infected group and the infected group were significantly higher than those in the control group (all P<0.05). The serum PCT levels in the infected group were significantly higher than those in the non-infected group on the 1st day and 3rd day after operation (all P<0.05).The level of serum PCT in the non-infection group was significantly higher than that in admission on the first day after operation (all P<0.05).In the non-infection group of intestinal perforation, there were significant differences in blood, intestinal content and gastric juice between the patients and the postoperative d1,d3,d7 serum PCT level (P<0.05).The serum PCT level in the patients with gastric and peritoneal effusion was the highest. The hospital stay time, antibiotic treatment course, antibiotic cost, hospitalization cost and APACHE-II score of the infected group were higher than that in the non-infected group (P<0.05). The case fatality rate of the infected group was higher than that of the control group, but the difference was not significant (P>0.05).【Conclusion】 PCT detection is of important clinical value in evaluating the severity of perforative peritonitis, and provides a reference for the diagnosis and identification of different types of celiac effusion, and can predict the prognosis of the patients. 2019 Vol. 36 (1): 28-31 [Abstract] ( 187 ) HTML (1 KB)  PDF  (0 KB)  ( 18 ) 32 Clinical Efficacy of Laparoscopic Surgery-assisted Triptorelin Acetate in the Treatment of Endometriosis with Infertility MI Gui-lan, SHU Zhi-ming, WU Jian-fa, et al DOI: 10.3969/j.issn.1671-7171.2019.01.010 【Objective】 To investigate the effect of laparoscopic surgery-assisted triptorelin acetate for the treatment of endometriosis with infertility.【Methods】 Seventy-two cases of endometriosis combined with infertility in our hospital were selected as the research objects. They were divided into the control group and the study group with thirty-six cases in each group according to the random number table method. All patients underwent laparoscopic surgery. The control group was given gestrinone treatment while the study group was given triptorelin acetate as adjunctive therapy. Both groups were treated for six months. We recorded the pelvic tumor size, dysmenorrhea score, endometriosis treatment life scale (EHP-5) score and serum hormone levels [luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E2)] in the two groups before and after treatment. The clinical efficacy, pregnancy outcomes and incidence of adverse reactions of the two groups were evaluated. 【Results】 After treatment, dysmenorrhea scores, EHP-5 scores and serum LH, FSH, E2 levels in the two groups were significantly decreased (P<0.05), and those in the study group were significantly lower than in the control group (P<0.05). The total effective rate of the study group was significantly higher than that of the control group (P<0.05). The pregnancy outcome was significantly better than that of the control group (P<0.05). The incidence of liver function damage was significantly lower than that of the control group (P<0.05). 【Conclusion】 The therapeutic effect of laparoscopic surgery-assisted triptorelin acetate in the treatment of endometriosis associated with infertility is significant. It can regulate the serum levels of LH, FSH and E2 and improve the outcome of pregnancy. 2019 Vol. 36 (1): 32-34 [Abstract] ( 149 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 35 Expression and Significance of CpG island Methylation of ATM Gene in ESCC FAN Wei, ZHENG Yu, YANG Zheng, et al DOI: 10.3969/j.issn.1671-7171.2019.01.011 【Objective】 To investigate the expression and significance of mutant gene ATM methylation of telangiectasis ataxia in esophageal squamous cell carcinoma(ESCC). 【Methods】 The methylation status of CpG island of ATM gene in 40 cases of esophageal squamous cell carcinoma was detected by bisulfite genomic sequencing (BSP) and TA clone sequencing , while normal esophageal tissue was used as the control group; immunohistochemical (SP) method was used to detect the expression of ATM protein in esophageal squamous cell carcinoma and normal tissues.【Results】 The methylation rate of CpG island of ATM gene in 40 cases of primary esophageal squamous cell carcinoma was 85.82%, which was significantly higher than that of 40 cases of adjacent normal tissues 59.59%(P<0.05). The expression of ATM protein in primary esophageal squamous cell carcinoma was significantly lower than that in normal tissues (P<0.05).【Conclusion】 The expression of ATM protein may be related to the methylation status of its gene CpG island, and its CpG island hypermethylation may lead to partial silencing of ATM protein expression, which may be a potential prognostic related factor. 2019 Vol. 36 (1): 35-37 [Abstract] ( 152 ) HTML (1 KB)  PDF  (0 KB)  ( 18 ) 38 Diagnostic Value of MRI Fast Imaging Sequence for Placenta Accreta in Middle and Late Pregnancy YI Yu-si, HUANG Feng, YU Yi-long DOI: 10.3969/j.issn.1671-7171.2019.01.012 【Objective】 To investigate the clinical value of MRI in the diagnosis of placenta accreta in middle and late pregnancy. 【Methods】 The clinical data of 35 patients with suspected placenta accreta admitted from April 2014 to August 2017 in our hospital were selected. MRI scan was performed with half Fourier single excitation and fast spin echo HASTE fat to suppress T2WI sequence so as to perform sagittal, transverse and coronal scans.The coincidence rate of MRI in diagnosis of placenta accreta with clinical operation and pathological diagnosis was analyzed.【Results】 (1) Among 24 cases of placental adhesion, 19 cases were confirmed by clinical operation and pathology, including 12 cases of placental adhesion on anterior wall, 7 cases of placental adhesion on posterior wall, and 5 cases were misdiagnosed as placental adhesions.(2) In 8 cases of placenta accreta, the placental base was uneven, and the placental base was mixed with the parenchyma with thick stripe hypotensive signal.The boundary between the placenta and the uterus was blurred. Middle and High implanted lesions were present in the myometrium of the uterus with low signal T2WI.(3) There were 3 cases of placental penetration, 2 of which penetrated the anterior and inferior wall of the uterus and invaded the bladder.A local disruption of the myometrium of the uterus was present.The moderately high signal placental tissue invades from the interruption.The placental tissue was fused with the myometrium of the uterus.The boundary between the serous layer of the uterus and the bladder was blurred."Tent-like" soft tissue signals protruded in the bladder cavity.One case penetrated the uterus backward.The fat gap in the rectocele disapperared.A slightly higher signal of T2WI can be seen in the serous layer of the upper rectum.【Conclusion】 The MRl rapid sequence has a great advantage in the diagnosis of placenta accreta, especially for the high diagnostic accuracy of the increta placenta and the penetrating placenta. 2019 Vol. 36 (1): 38-40 [Abstract] ( 143 ) HTML (1 KB)  PDF  (0 KB)  ( 21 ) 41 Expression of E-cadherin and Snail in Prostate Cancer and Its Association with Postoperative Biochemical Recurrence LI Gang, ZHU Yang-ting, LI Ning, et al DOI: 10.3969/j.issn.1671-7171.2019.01.013 【Objective】 To investigate the expression of E-cadherin and transcription factor Snail in prostate cancer and its clinical significance. 【Methods】 From January 2005 to December 2006, 54 cases of prostate cancer (prostate cancer group) were collected, and 48 cases of benign prostatic hyperplasias (benign prostatic hyperplasia group) were also collected. Immunohistochemistry was used to detect the expression of E-cadherin and Snail protein. The relationship between biochemical recurrence time and expression of E-cadherin and Snail protein in prostate cancer patients was analyzed by Kaplan-Meier method. 【Results】 The positive expression rate of E-cadherin in prostate cancer group (37.04%,20/54) was significantly lower than that in benign prostatic hyperplasia group (83.33%,40/48,P<0.05), while the positive expression rate of Snail in prostate cancer group (62.96%,34/54) was significantly higher than that in benign prostatic hyperplasia group (22.92%,11/48) (P<0.05). The expression of E-cadherin and Snail in prostate cancer tissues was associated with TNM stage, histological differentiation, lymph node metastasis and distant metastasis (P<0.05). The expression of E-cadherin in prostate cancer tissues was negatively correlated with Snail expression (rs=-0.762,P<0.05). Kaplan-Meier analysis showed that biochemical recurrence-free survival in the E-cadherin positive group was significantly higher than that in the E-cadherin negative group (P<0.05), and biochemical recurrence-free survival in the Snail negative group was significantly higher than that in the Snail positive group (P<0.05). 【Conclusion】 The expression of E-cadherin protein is low, while the expression of Snail protein is high in prostate cancer tissues. The expression levels of E-cadherin and Snail are related to occurrence, development and prognosis of prostate cancer. 2019 Vol. 36 (1): 41-43 [Abstract] ( 137 ) HTML (1 KB)  PDF  (0 KB)  ( 18 ) 44 Effect of Intravitreal Ranibizumab-assisted PPV on Proliferative Diabetic Retinopathy and Its Effects on Cell Factors in Aqueous Humor ZHANG Qi-ming, RUAN Xue-wu DOI: 10.3969/j.issn.1671-7171.2019.01.014 【Objective】 To observe the efficacy of intravitreal injection of Ranibizumab in assisted Pars Plana Vitrectomy (PPV) for proliferative diabetic retinopathy (PDR) , and the effect on levels of vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), IL-8 and monocyte chemokine protein-1 (MCP-1) .【Methods】 One hundred and forty-six patients with PDR (all monocular diseases) admitted to our hospital from June 2015 to June 2017 were selected and randomly divided into three groups: A, B and C. In the group A, 50 cases (50 eyes) were treated with PPV 4 days after Razumab injection; in the group B, 48 cases (48 eyes) were treated with PPV 10 days after Razumab injection; and in the group C, 48 cases (48 eyes) were treated with PPV operation only. The therapeutic effect was observed and the levels of vascular endothelial growth factor, interleukin-6, interleukin-8 and MCP-1 were compared before and after treatment. 【Results】 The operation time of the group A and group B was significantly shorter than that of the group C (P<0.05); the average bleeding times, electrocoagulation times and silicone oil filling rate were significantly less than those of the group C (P<0.05); but there was no significant difference in operation time, average bleeding times, electrocoagulation times and silicone oil filling rate between the group A and the group B (P>0.05). The incidence of vitreous hemorrhage and iatrogenic retinal hole in the group A and B was significantly lower than that in the group C (P<0.05); the proportion of patients with visual acuity of 0.3~0.5 and > 0.5 in the group A and B was significantly higher than that in the group C (P<0.05); the ratio of manual operation and anterior ocular index in the group A and B was significantly lower than that in the group C (P<0.05); the average intraocular pressure in the group A and B was significantly lower than that in the group C (P<0.05). Visual acuity was significantly higher than that of the group C (P<0.05), but there was no significant difference between the group A and the group B (P>0.05). On the 7th day after treatment, the levels of VEGF and IL-18 in aqueous humor of the group A and the group B were significantly lower than those of the group C, and the levels of IL-6 and MCP-1 were significantly higher than those of the group C (P<0.05), but there was no significant difference between the group A and the group B (P>0.05).【Conclusion】 The intravitreal injection of Ranibizumab-assisted PPV is effective in the treatment of proliferative diabetic retinopathy. It can effectively improve the visual acuity of patients, and has a high application value. It is an ideal time for injection 4 days before surgery. 2019 Vol. 36 (1): 44-48 [Abstract] ( 123 ) HTML (1 KB)  PDF  (0 KB)  ( 18 ) 49 Application of PET/CT and HRCT in the Differential Diagnosis of Peripheral Lung Cancer ZHU Rong-hua, WANG Shu-zhong, ZHANG Huai DOI: 10.3969/j.issn.1671-7171.2019.01.015 【Objective】 To investigate the application of PET/CT and HRCT in the differential diagnosis of peripheral lung cancer. 【Methods】 A retrospective analysis of 152 patients with suspected peripheral lung cancer from February 2014 to March 2017 was performed. All patients underwent PCT/CT and HRCT examination after admission, and were confirmed by histology, puncture or addition. The number and size of the lesions were determined, the maximum standardized intake of the lesion area was calculated, and the area of HRCT,PET/CT and their combination were analyzed under the receiver operating curve (ROC) of the subjects for the diagnosis of peripheral lung cancer.【Results】 (1) 24 cases had lesions of 0.5~1 cm in diameter, 22 cases had clear signs in PET/CT and 19 cases had clear signs in HRCT; (2) 55 cases had lesion diameter of 1~2 cm, 53 cases had clear signs in PET/CT and 55 cases had clear signs in HRCT; (3) 36 cases had lesion diameter of 2~3 cm, 38 cases had clear signs in PET/CT and 34 cases had clear signs in HRCT; (4) the standardized maximum uptake of peripheral lung cancer was significantly higher than that of non-peripheral lung cancer (P<0.05); (5) 106 cases were diagnosed as peripheral lung cancer by PET/CT, and 1 case was negative. In 9 cases, the sensitivity, specificity and accuracy of diagnosing peripheral lung cancer were 84.80%, 70.37% and 82.23%, respectively; (6) HRCT was used to diagnose 93 cases of peripheral lung cancer and 32 cases of negative lung cancer. The sensitivity, specificity and accuracy of diagnosing peripheral lung cancer were 74.40%, 81.48% and 75.65%, respectively; (7) PET/CT+HRCT was used to diagnose 113 cases of peripheral lung cancer, 12 cases of negative lung cancer and 12 cases of peripheral lung cancer. The sensitivity, specificity and accuracy were 90.40%, 88.89% and 90.13% respectively. 【Conclusion】 The combination of HRCT and PET/CT can significantly reduce the misdiagnosis rate of peripheral lung cancer, and significantly improve the sensitivity, specificity and accuracy of the diagnosis of peripheral lung cancer. 2019 Vol. 36 (1): 49-51 [Abstract] ( 179 ) HTML (1 KB)  PDF  (0 KB)  ( 16 ) 52 Effect of U0126 on Corneal Epithelial Cell Activity Induced by High Glucose ZHU Xi-yu, WANG Xiao-ping, MAO Xiao-chun, et al DOI: 10.3969/j.issn.1671-7171.2019.01.016 【Objective】 To investigate the effect of U0126 on activity of human corneal epithelial cells (HCEC) induced by high glucose. 【Methods】 HCEC was divided into normal group (5.5 mmol/L glucose), high glucose group (50 mmol/L glucose) and U0126 low, medium and high concentration group (5, 10, 20 micron o/L, U0126 + 50 mmol/L glucose), and cultured for 48 hours. Cell viability, apoptosis, ROS fluorescence intensity, calcium concentration, mitochondrial membrane potential, aspartate proteolytic enzyme 3 (Caspase 3) and Caspase 9 activity, and the expression of Bcl-2, Bax and Cyt C protein were measured.【Results】 Compared with the high glucose group, the cell viability of U0126 low, medium and high concentration groups was significantly increased (P<0.01), the apoptotic rate, ROS fluorescence intensity, calcium concentration and Caspase 3, 9 activity were decreased (P<0.01), the mitochondrial membrane potential was increased (P<0.01), the expression of Bcl-2 was up-regulated (P<0.01), the expression of Cyt C in cytoplasm was down-regulated (P<0.01), and the expression of Bax in U0126 medium and high concentration groups was down-regulated (P<0.01).【Conclusion】 U0126 may resist apoptosis of HCEC cells induced by high glucose through mitochondrial pathway. 2019 Vol. 36 (1): 52-54 [Abstract] ( 111 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 55 Serum Levels and Clinical Significances of UA, IL-6 and SF in Patients with Nonalcoholic Fatty Liver Disease LIU Xiao-hong, LI Wen-hua, JIANG Shu-jie DOI: 10.3969/j.issn.1671-7171.2019.01.017 【Objective】 To explore serum levels of uric acid (UA), interleukin-6 (IL-6) and ferritin (SF) in patients with nonalcoholic fatty liver disease (NAFLD) and their clinical significances. 【Methods】 The clinical data of 82 patients with NAFLD admitted to our hospital from May 2016 to March 2018 were divided into the mild NAFLD group (n=27) and the moderate NAFLD group (n=34) and the severe NAFLD group (n=21). At the same time, 30 healthy subjects were selected as the control group. Serum levels of UA, IL-6, SF, blood lipids [total cholesterol (TC), triglycerides (TG)], liver function [aspartate aminotransferase (AST), alanine aminotransferase (ALT)] and insulin resistance [fasting plasma glucose (FBG), fasting Insulin (FINS), insulin resistance index (HOMA-IR)] were measured in all patients. 【Results】 Serum TG, TC,AST, ALT, UA, IL-6 levels in the NAFLD group were significant higher than those in the control group (P<0.05). Serum FBG, FINS,UA, IL-6 levels and HOMA-IR in the moderate and severe NAFLD groups were significant higher than those in the mild NAFLD group and the control group (P<0.05). The HOMA-IR value in the severe NAFLD group was significant higher than that in the moderate NAFLD group (P<0.05). Pearson correlation analysis showed that serum UA levels in cases with NAFLD were positively correlated with BMI (r=2.572), FINS (r=0.244) and HOMA-IR (r=2.730) (P<0.05) and serum IL-6 levels were positively correlated with BMI (r=2.375), ALT (r=2.728) and HOMA-IR (r=0.254) (P<0.05). It also showed that serum SF content was positively correlated with BMI (r=0.285), ALT (r=0.372), FINS (r=0.243), and HOMA-IR (r=0.274) (P<0.05). IL-6 was positively correlated with SF (r=0.304, P<0.05).【Conclusion】 Serum UA, IL-6 and SF levels in NAFLD patients were abnormally high, which were closely related to the severity of the disease and also highly correlated with insulin resistance. 2019 Vol. 36 (1): 55-58 [Abstract] ( 150 ) HTML (1 KB)  PDF  (0 KB)  ( 18 ) 59 Application of 3D Printing Technology in Early Onset Spinal Deformity Surgical Treatment LIU Shao-hua, MEI Hai-bo, YE Wei-hua, et al DOI: 10.3969/j.issn.1671-7171.2019.01.018 【Objective】 To explore the efficiency of 3D printing technology in early onset spinal deformity (congenital scoliosis) surgical treatment. 【Methods】 The clinical data of 26 patients with congenital scoliosis who underwent surgery correction and received complete follow-up from May 2016 to August 2018 were selected in this study. Among them, 14 patients underwent malformation surgery under the guidance of 3D printing technology (the experimental group), 12 patients underwent spinal deformity surgery under the guidance of CT three-dimensional reconstruction. The operative time, intraoperative bleeding volume, accuracy of pedicle placement and the incidence of surgical related complications between the two groups were observed. 【Results】 The operative time and intraoperative bleeding volume in the experimental group were significantly lower than those in the control group (P<0.05). There was no significant difference in the accuracy of the pedicle screw position between the experimental group and the control group (P>0.05). 【Conclusion】 The application of 3D printing technology in congenital scoliosis correction surgery can shorten the operation time and reduce the amount of intraoperative blood loss, which is worthy of clinical application. 2019 Vol. 36 (1): 59-61 [Abstract] ( 118 ) HTML (1 KB)  PDF  (0 KB)  ( 17 ) 62 Effects of Carvedilol and Bisoprolol on Cardiopulmonary Function and Quality of Life in Patients with Chronic Obstructive Pulmonary Disease Complicated with Heart Failure ZHANG Hao, WANG He, GU Lei DOI: 10.3969/j.issn.1671-7171.2019.01.019 【Objective】 To investigate the clinical efficacy of carvedilol and Bisoprolol in the treatment of patients with chronic obstructive pulmonary disease (COPD) complicated with heart failure (HF) and their effects on cardiopulmonary function and quality of life. 【Methods】 The clinical data of 138 patients with COPD combined with HF from February 2017 to January 2018 were analyzed retrospectively. According to the difference of treatment drugs, they were divided into control group and observation group with 69 cases in each group. Both groups were given routine medical treatment, the control group was treated with carvedilol and the observation group with Bisoprolol for 6 months. The clinical efficacy and heart and lung function of the two groups were compared. The quality of life (QOL) was evaluated by score of St. George's Respiratory questionnaire (SGRQ). 【Results】 The total effective rate was 92.8% (64/69) in the observation group and 81.2% (56/69) in the control group. The difference was statistically significant (χ2=4.089,P=0.043＜0.05). After 6 months of treatment, the vital capacity of (VC) in the control group was not significantly different from that before treatment (P>0.05), and the VC in the observation group was significantly higher than that before treatment (P<0.05). The resting heart rate, walking distance of 6 min and peak respiratory velocity (PEF) were significantly improved in the two groups after treatment, and the difference was statistically significant in the observation group than in the control group (P<0.05). After treatment, the activity ability, respiratory symptoms, disease impact score and total SGRQ score of the two groups were significantly lower than those of the control group (P<0.05), and those of the observation group were lower than those of the control group (P<0.05). The incidence of adverse reactions in the control group was 2.90% (2/69), which was lower than that in the observation group (4.35%). There was no significant difference between the two groups (χ2= 0.208,P<0.05). 【Conclusion】 Both carvedilol and bisoprolol could significantly improve the heart and lung function of COPD patients with HF, and improve their quality of life, but the efficacy of bisoprolol is better than that of carvedilol. 2019 Vol. 36 (1): 62-64 [Abstract] ( 106 ) HTML (1 KB)  PDF  (0 KB)  ( 19 ) 65 Effects of Rubescene B Combined with Capecitabine on Proliferation and Invasion of Breast Cancer Cells ZHANG JUN-mei DOI: 10.3969/j.issn.1671-7171.2019.01.020 【Objective】 To investigate the effect of rubescene B combined with capecitabine on proliferation and invasion of breast cancer cells.【Method】 The breast cancer cell line 4T1was established and randomly divided into four groups: rubescene B group (group A), capecitabine group (group B), rubescene B + capecitabine group (group C) and blank control group (group D). MTT assay was used to detect the increment inhibition rate of breast cancer cell line 4T1 in each group. The effect of drugs on invasive ability of breast cancer cell line 4T1 was determined by Transwell chamber assay. RT-PCR method was used to detect the expression of beta-catenin, cyclin D1 and c-myc mRNA in breast cancer cell line 4T1. 【Results】 Treatment in group A, B and C all inhibited the proliferation of breast cancer 4T1 cells, and group C had the strongest inhibition, which was higher than the other groups (P<0.05). The invasiveness of breast cancer 4T1 cells was inhibited in group A, group B and group C. The invasiveness of breast cancer 4T1 cells in group C was the weakest, which was lower than that of the other three groups (P<0.05). The expression of beta-catenin, cyclin D1 and c-myc was significantly down-regulated by rubescene B combined with capecitabine (P<0.05). 【Conclusions】 Rubescene B combined with capecitabine can significantly inhibit the proliferation of breast cancer 4T1 cells, and inhibit cell invasion, which is related to the suppressing the Wnt/β-catenin signaling transduction pathway. 2019 Vol. 36 (1): 65-67 [Abstract] ( 123 ) HTML (1 KB)  PDF  (0 KB)  ( 16 ) 68 Clinical Analysis of 3D Printing Technology in the Treatment of Complex Acetabular Fractures SHI Yan-hai, LI Guan-xing DOI: 10.3969/j.issn.1671-7171.2019.01.021 【Objective】 To investigate the clinical analysis of 3D printing technology in the treatment of complex acetabular fractures. 【Methods】 Eighty patients with complex acetabular fractures treated in our hospital from January 2016 to December 2017 were selected and divided into the observation group (n=38) and the control group (n=42) according to the final selected treatment, the observation group was given 3D printing assistant treatment, while the control group was given conventional surgery, the operation conditions, fracture reduction and hip joint function and so on of the two groups were observed. 【Results】 The amount of bleeding, operation time, incision length and intraoperative fluoroscopy in the observation group were significantly less than that in the control group (P<0.05); The fracture reduction and hip joint function of the observation group were better than those of the control group (P<0.05); The VAS scores of the observation group at 1 week and 1 month after operation were significantly lower than those of the control group (P<0.05); The incidence of postoperative complications in the observation group was significantly lower than that in the control group (P<0.05). 【Conclusion】 3D printing technology has a good clinical effect in the treatment of complex acetabular fractures, and is worthy of clinical application. 2019 Vol. 36 (1): 68-70 [Abstract] ( 134 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 71 Effect of Diversified Nutritional Health Education on Nutritional Knowledge, Belief and Practice and Nutrition Status of Patients with Esophageal Cancer Surgery WANG Lin-lin, WANG Bo, ZHANG Shan-shan DOI: 10.3969/j.issn.1671-7171.2019.01.022 【Objective】 To investigate the effects of diversified health education on nutritional knowledge, belief and practice (KBP) and evaluate nutritional status of discharged patients with esophageal cancer radical surgery. 【Methods】 Eighty-four patients with esophageal cancer radical surgery from July 2016 to October 2017 were enrolled. The prospective study was used and the patients were randomly divided into the treatment group and the control group with 42 patients in each group. The control group received routine continuous nursing interventions including health education, dietary intervention and follow-up guidance, while the treatment group was combined the application of diversified nutrition health education in addition to those interventions of the control group. After 6 months of follow-up, the indicators of nutritional KBP level, serum nutrition indicators and adverse reactions were compared between the two groups. 【Results】 The nutritional KBP, nutritional attitude and nutritional behavior scores of the patients in the treatment group were significantly higher than those in the control group (t=4.747, 9.293, 3.467,respectively, P<0.05, P<0.01). Serum albumin (ALB), prealbumin (PA) and transferrin (TRF) levels in the treatment group were significantly higher than those in the control group (t=4.940, 3.848, 2.476, respectively, P<0.05). The incidence of adverse reactions such as reflux esophagitisin the treatment group was significantly lower than that in the control group (χ2=5.486, P<0.05). 【Conclusion】 Diversified nutritional health education can improve the KBP level of discharged patients after radical resection of esophageal cancer, promote the nutritional status and reduce the occurrence of adverse reactions. 2019 Vol. 36 (1): 71-73 [Abstract] ( 115 ) HTML (1 KB)  PDF  (0 KB)  ( 18 ) 74 Changes of Serum TGF-β1,CTGF Levels and their Correlation with Cardiac Function in Elderly Patients with Hypertension and Chronic Heart Failure ZHEN Hai-xu DOI: 10.3969/j.issn.1671-7171.2019.01.023 【Objective】 To investigate the changes of serum transforming growth factor-β1(TGF-β1) and connective tissue growth factor (CTGF) levels in elderly hypertensive patients with chronic heart failure (CHF) and their correlation with cardiac function. 【Methods】 The clinical data of 130 elderly patients with hypertension complicated with CHF from January 2018 to July 2018 were selected (observation group) and 60 elderly patients with simple hypertension were selected as control group. Serum TGF-β1,CTGF and cardiac function were compared between the two groups, and the correlation between serum TGF-β1,CTGF and cardiac function was analyzed by Pearson correlation. 【Results】 The left ventricular ejection fraction (LVEF) in the observation group was significantly lower than that in the control group, and the left ventricular mass index (LVMI) of left ventricular end-diastolic diameter (LVEDd) was significantly higher than that of the control group (P<0.05). The serum levels of TGF-β1, CTGF in the observation group were significantly higher than those in the control group (P<0.05). The serum levels of TGF-β1,CTGF in patients with NYHA grade Ⅱ, Ⅲ and Ⅳ increased with the increase of NYHA grade, and the difference between the two groups was statistically significant (P<0.05). There was a significant negative correlation between serum TGF-β1,CTGF and LVEF in hypertensive patients with CHD, and a positive correlation between serum TGF-β1,CTGF and LVMI (P<0.05).【Conclusion】 Serum TGF-β1 and CTGF are significantly increased in elderly patients with hypertension and chronic heart failure and are closely related to cardiac function and myocardial remodeling. 2019 Vol. 36 (1): 74-76 [Abstract] ( 120 ) HTML (1 KB)  PDF  (0 KB)  ( 18 ) 77 Effect of Helicobacter Pylori ( HP) Infection on Proliferation, Invasion and Metastasis of Hepatocellular Carcinoma(HCC) TIAN Yan-long DOI: 10.3969/j.issn.1671-7171.2019.01.024 【Objective】 To investigate the effect of Helicobacter pylori (HP) infection on proliferation, invasion and metastasis of hepatocellular carcinoma (HCC).【Methods】 Eighty liver cancer specimens from March 2015 to March 2017 and 80 normal liver specimens (> 5 cm from the edge of the cancer tissue) were selected as study samples. Each sample was divided into two parts, one was detected for HP immediately, the other was detected by immunohistochemistry for the expression of proliferation-related factor [B lymphocytoma 2 gene (Bcl-2), apoptosis suppressor gene (Survivin)] and invasion and metastasis related factor [transagglutinin (Transgelin),Integrinα2, cell adhesion factor (ICAM-1)], Matrix metalloproteinase 2 (MMP-2) and vascular endothelial growth factor (VEGF).【Results】 The positive rate of HP in HCC tissues was significantly higher than that in normal liver tissues, and the positive rate of proliferation, invasion and metastasis related factors in HCC tissues was significantly higher than that in normal liver tissues (P<0.05). The positive rates of Bcl-2 and Survivin were 92.73% and 94.55% in HP-infected liver cancer tissues, respectively, which were significantly higher than those in non-HP-infected liver cancer tissues (P<0.05); the positive rates of Transgelin, Integrin alpha 2, ICAM-1, MMP-2 and VEGF in HP-infected liver cancer tissues were 92.73%, 96.36%, 94.55%, 92.73% and 96.36%, respectively, which were significantly higher than those in non-HP-infected liver cancer tissues (P<0.05). 【Conclusion】 HP is involved in the occurrence and development of HCC, and can promote the proliferation, invasion and metastasis of HCC. 2019 Vol. 36 (1): 77-79 [Abstract] ( 122 ) HTML (1 KB)  PDF  (0 KB)  ( 18 ) 80 Effect of Rapid Rehabilitation Nursing with the Assistance of Multidisciplinary Team on Stress Response and Quality of Life in Elderly Patients after Cataract Surgery DING Qian, LAI Feng-ming, LIU Jing, et al DOI: 10.3969/j.issn.1671-7171.2019.01.025 【Objective】 To explore the effect of rapid rehabilitation nursing assisted by multidisciplinary team (MDT) on stress response and quality of life in elderly patients after cataract surgery. 【Methods】 A total of 154 cases of elderly patients who received cataract surgery in our hospital from January 2016 to September 2017 were divided into the observation group and the control group according to different nursing methods, with 77 cases in each group. The control group was given routine nursing intervention, while the observation group was given rapid rehabilitation nursing with the help of MDT. Stress response, mental state, complications and quality of life were compared between the two groups. 【Results】 The stress response index of the observation group was significantly better than that of the control group (P<0.05). There were no significant differences in self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores between the two groups before nursing (P>0.05), while the scores of SAS and SDS after nursing were significantly lower than those before nursing (P<0.05), and the observation group scores were significantly lower than those of the control group (P<0.05). The incidence of complications in the observation group was 6.49%, which was significantly lower than that in the control group 19.48% (P<0.05); the quality of life score in the observation group was significantly higher than that in the control group (P<0.05). 【Conclusion】 With the help of MDT, the application of rapid rehabilitation nursing in elderly patients after cataract surgery can effectively improve the status of anxiety and depression, alleviate stress response, reduce complications and improve the quality of life, which is worthy of clinical application. 2019 Vol. 36 (1): 80-82 [Abstract] ( 92 ) HTML (1 KB)  PDF  (0 KB)  ( 19 ) 83 AApplication of Detail Nursing in the Treatment of Postpartum Urinary Retention by Low-frequency Electrical Stimulation of Pelvic Floor Muscles WEN Gui-ping, GONG Ju-xiang DOI: 10.3969/j.issn.1671-7171.2019.01.026 【Objective】 To study the clinical effect of detail nursing in the treatment of postpartum urinary retention(PUR) by low frequency electric stimulation(LFES) on pelvic floor muscle. 【Methods】 From March 2015 to September 2017, 82 patients with PUR were randomly divided into two groups: the observation group (n=41) and the control group (n=41). All received LFES therapy.The control group was treated with routine nursing, and the observation group was given detailed nursing on the basis of the control group. The nursing effect was compared between the two groups.【Results】 The first urination and hospitalization time of the observation group was shorter than that of the control group, and the residual urine volume of the observation group was less than that of the control group (P<0.05). The scores of each dimension of quality of life in the two groups were improved after nursing, and the scores in the observation group were significantly higher than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group and the control group (P>0.05).【Conclusion】 During the treatment of PUR patients with LFER, the application of detail nursing can promote urination and reduce adverse reactions, so it is worth popularizing. 2019 Vol. 36 (1): 83-85 [Abstract] ( 113 ) HTML (1 KB)  PDF  (0 KB)  ( 18 ) 86 Levels of sRAGE and IL-32 in Induced Sputum and Serum of COPD Patients and their Relationship with Pulmonary Function HE Yu-yu, YANG Jing DOI: 10.3969/j.issn.1671-7171.2019.01.027 【Objective】 To investigate the levels and significance of soluble advanced glycation end product receptor (sRAGE) and Interleukin-32 (IL-32) in induced sputum and serum of patients with chronic obstructive pulmonary disease (COPD). 【Methods】 Eighty-nine COPD patients (COPD group) treated in our hospital from September 2017 to October 2018 were selected, including 33 acute exacerbation patients and 56 stable patients, 90 healthy volunteers were selected as control group, the induced sputum and serum levels of sRAGE and IL-32 were measured. At the same time, the pulmonary function index was detected.【Results】 The levels of sRAGE and IL-32 in induced sputum and serum in the observation group were significantly lower than those in the control group (P<0.05). The levels of induced sputum and serum sRAGE in the acute exacerbation group were significantly lower than those in the stable phase group (P<0.05). The level of IL-32 was significantly higher than that of the stable group (P<0.05). The percentage of forced expiratory volume (FEV1) / forced vital capacity (FVC)and FEV1 in the first second of acute exacerbation of COPD was significantly lower than that in the stable group (P<0.05). Induced sputum sRAGE and IL-32 were positively correlated with serum sRAGE and IL-32 (r=0.463, P<0.05, r=0.480, P<0.05); induced sputum sRAGE or IL-32 was negatively correlated with the percentage of FEV1/FVC and FEV1(r=-4.332, -4.402, P<0.05 or r=-450, -4.462, P<0.05).【Conclusion】 The levels of sRAGE and IL-32 in induced sputum and serum of COPD patients decreased, while IL-32 increased. The levels of sRAGE and IL-32 in induced sputum were closely related to liver function. The levels of sRAGE and IL-32 in induced sputum could reflect the pulmonary function of COPD patients. 2019 Vol. 36 (1): 86-88 [Abstract] ( 115 ) HTML (1 KB)  PDF  (0 KB)  ( 17 ) 89 Effect of VATS Treatment on Serum Infectivity Index, CTCs and Tumor Marker Levels in Patients with NSCLC ZHANG Li, ZHANG Jing, WANG Yuan, et al DOI: 10.3969/j.issn.1671-7171.2019.01.028 【Objective】 To investigate the effects of video-assisted thoracoscopic (VATS) surgery on serum infectivity, peripheral circulating tumor cells (CTCs), and serum tumor markers in patients with NSCLC. 【Methods】 Eigity-six86 patients with NSCLC were divided into VATS group (group A) and traditional thoracotomy group (group B). Serum levels of serum C-reactive protein (CRP), calcitonin procalcitonin (PCT), tumor necrosis factor-α(TNF-α) and interleukin-1β (IL-1β), CTCs were compared between the two groups before and 24 hours after operation. The changes of serum vascular endothelial growth factor (VEGF), matrix metalloproteinase 9 (MMP-9) and carcinoembryonic antigen (CEA), cell keratin 19 fragment (CYFRA2-1) were compared between the two groups before and 1 month after operation.【Results】 The serum levels of CRP,PCT,TNF-α, IL-1β and CTCs in group A were significantly lower than those in group B 24 hours after operation (P>0.05). One month after operation, the serum VEGF,MMP-9,CEA,CYFRA2-1 level in the two groups was significantly lower than that before operation (P<0.05), but there was no significant difference between the two groups (P>0.05).【Conclusion】 Compared with the traditional open chest surgery, the patients with NSCLC treated with VATS has less influence on the serum infection index, the degree of tumor cell dissemination is lower, and the serum tumor markers are reduced to the same extent after operation. 2019 Vol. 36 (1): 89-91 [Abstract] ( 111 ) HTML (1 KB)  PDF  (0 KB)  ( 17 ) 92 Application of Optical Coherence Tomography Angiography in Evaluating the Efficacy of Vitrectomy in Elderly Patients with Idiopathic Macular Hole LV Xiao-xia, YANG Li, FENG Zhao-hui, et al DOI: 10.3969/j.issn.1671-7171.2019.01.029 【Objective】 To investigate the value of optical coherence tomography angiography (OCTA) in evaluating the efficacy of vitrectomy in elderly patients with idiopathic macular hole. 【Methods】 Forty-six cases (46 eyes) of elderly patients with idiopathic macular hole who underwent vitrectomy in our hospital from January 2015 to March 2017 were selected as objects of observation. All patients were examined by OCTA before and one month after operation. The changes of hole diameter, hole edge thickness, halo diameter, retinal thickness and retinal nerve fiber layer thickness were observed before and after operation.The macular hole healing was followed up 1 month after operation. 【Results】 One month after operation, 31 cases (31 eyes) healed completely, 11 cases (11 eyes) healed partially and 4 cases (4 eyes) did not heal, accounting for 67.39%, 23.91% and 8.70% respectively. Preoperative OCTA showed that the average diameter of the hole, the average thickness of the edge of the hole and the average diameter of the halo were all smaller than those before operation. One month after operation, OCTA showed that the thickness of the fovea, the retina of the inner macular ring, the retinal nerve fiber layer of the upper and nasal sides of the inner macular ring were significantly reduced compared with those before operation, and the difference was statistically significant (all P<0.05). 【Conclusion】 OCTA can more objectively, accurately and effectively judge the effect of histological structure of patients with idiopathic macular hole after vitrectomy, and it is an effective means of follow-up examination after surgery. 2019 Vol. 36 (1): 92-94 [Abstract] ( 98 ) HTML (1 KB)  PDF  (0 KB)  ( 19 ) 95 Study on the Clinical Efficacy and Safety of Pirarubicin, Gemcitabine and Cisplatin in the Treatment of Advanced Bladder Cancer HUANG Yin-qing, LIU Ling, LIU Shuang, et al DOI: 10.3969/j.issn.1671-7171.2019.01.030 【Objective】 To analyze the clinical efficacy and safety of pirarubicin, gemcitabine and cisplatin in the treatment of advanced bladder cancer. 【Methods】 A total of 575 patients with advanced bladder cancer were randomly divided into the control group (286 cases) and the research group (289 cases). Patients in the control group received gemcitabine and cisplatin treatment, while patients in the research group received pirarubicin in addition to gemcitabine and ciaplatin. The clinical efficacy, tumor markers, safety and survival of the two groups were compared. 【Results】 The total effective rate in the research group was 77.51% (224/289), which was significantly higher than that of the control group (51.75%, 148/286). The difference was statistically significant (P<0.05). Serum fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), and secretory protein (DKK) levels decreased in both groups compared with before treatment, Levels in the research group were significantly lower than those in the control group(P<0.05). There was no significant difference in the incidence of nausea and vomiting, neutropenia, and rash between the two groups(P>0.05). The incidence of thrombocytopenia, alopecia, and fatigue in the research group was higher than that in the control group. The difference was statistically significant between the two groups (P<0.05). The 1-year and 2-year overall survival rates of the resaerch group were 83.74%(242/289)and 61.25%(177/289), respectively, which were higher than the control group's 61.19%(175/286)and 35.31%(101/286), respectively (P<0.05). 【Conclusion】 Clinical efficacy of pirarubicin, gemcitabine combined with cisplatin in the treatment of advanced bladder cancer is superior to gemcitabine plus cisplatin, which can improve the patients' survival time without significantly increasing the adverse reactions. 2019 Vol. 36 (1): 95-97 [Abstract] ( 140 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 98 Correlation between Serum chondroprotein 39 ,Homocysteine and the Occurrence of MACE after PCI in Patients with CHD ZHAO Yue-chao, LIU Shao-kui, WANG Xiao-mei DOI: 10.3969/j.issn.1671-7171.2019.01.031 【Objective】 To investigate the relationship between serum levels of human chondroprotein 39 (YKL-40),homocysteine (Hcy) and the occurrence of major cardiovascular events (MACE) after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD).【Methods】 The clinical data of 104 patients with CHD treated with PCI from March 2015 to April 2012 were selected. According to the results of 12 months follow-up, they were divided into two groups: the observation group (MACE event,n=34) and the control group (no MACE event,n=70). The general data of the two groups were collected and the serum YKL-40,Hcy levels were measured before and after PCI operation. Multivariate Logistic regression analysis was used to analyze the risk factors of MACE.【Results】 There was no significant difference in age, sex, BMI, hypertension, hyperlipidemia, smoking, alcohol consumption and CHD family history between the two groups (P>0.05). Compared with the control group, the number of stent implantation in the observation group was significantly different from that in the control group (P<0.05). There was no significant difference in serum YKL-40,Hcy levels between the two groups before operation (P>0.05). The serum YKL-40,Hcy level in the observation group was significantly higher than that in the control group at 24 hours after operation (P<0.05). The serum YKL-40,Hcy level was higher than that in the control group (P<0.05), and the number of stents implanted was more than 2. Diabetes mellitus was a risk factor for MACE events after PCI in patients with CHD (P<0.05). 【Conclusion】 The high- level expression of serum YKL-40,Hcy and the increase of serum YKL-40,Hcy, the number of stents>2 and diabetes mellitus are the risk factors of MACE after PCI in CHD patients. 2019 Vol. 36 (1): 98-100 [Abstract] ( 116 ) HTML (1 KB)  PDF  (0 KB)  ( 17 ) 101 Curative Effect of Shugan Jieyu Capsule Combined with Low-dose of Clomipramine on Depression Treatment BAI Cun-hai, YU Li-yan DOI: 10.3969/j.issn.1671-7171.2019.01.032 【Objective】 To investigate the curative effect of Shugan Jieyu capsule combined with clomipramine in the treatment of depression. 【Methods】 A total of 96 patients with depression who were admitted to our hospital from October 2016 to October 2017 were divided into the control group and the experimental group according to random number table method. There were 48 patients in the control group and 48 patients in the experimental group. Patients in the control group were treated with clomipramine tablets at conventional dose, while patients in the experimental group were treated with Shugan Jieyu capsules combined with low-dose of clomipramine tablets. Both groups of patients were treated for 8 weeks. The Hamilton Depression Self-rating Scale (HAMD), and Ability of Daily Living Scale (ADL) were observed before and after treatment. 【Results】 The HAMD scores of the control group and the experimental group before treatment were (27.41±2.73) points and (28.19±2.58) points, respectively. After treatment, the HAMD score of the control group was 18.35±2.49 and the score of the experimental group was 9.82±2.16 , which showed lower than before treatment. The differences were statistically significant (t=3.266, P=0.002<0.05). The incidence of total adverse reactions in the control group was 29.17% (5/48) while the incidence of total adverse reactions in the experimental group was 10.42% (14/49). The difference between the two groups was statistically significant (χ2=5.315, P=0.021<0.05). The ADL scores of the control group and the experimental group were 41.23±22.25 and 42.68±23.09, respectively. After treatment, the HAMD scores of the experimental group and the control group were 62.83±19.14 and 53.47±21.97, respectively,. which were higher than before treatment. The difference was statistically significant (t=-2.226, P=0.028<0.05). 【Conclusion】 Shuganjieyu Capsules combined with clomipramine have a good effect in the treatment of depression, which significantly improves the clinical symptoms of depression in patients, reduces the adverse reactions during treatment, and promotes the daily living ability of patients. 2019 Vol. 36 (1): 101-102 [Abstract] ( 121 ) HTML (1 KB)  PDF  (0 KB)  ( 16 ) 103 Serum HDAC2 and IL-17A Levels in Patients with Chronic Obstructive Pulmonary Disease and Their Clinical Significance LI Rui-min, DING Yan-yan, ZHANG Yong-xiang DOI: 10.3969/j.issn.1671-7171.2019.01.033 【Objective】 To investigate the levels of histone deacetylase (HDAC2) and interleukin-17A (IL-17A) in patients with chronic obstructive pulmonary disease (COPD) and to analyze the clinical significance. 【Methods】 Patients with COPD who were treated in our hospital from August 2017 to May 2018 were selected as the study subjects (COPD group,n=40), and healthy adults who received physical examination in the same period were selected as the control group (n=40). The levels of HDAC2, IL-17A, pulmonary function and blood gas were compared between the two groups, and the correlation of the levels of HDAC2 and IL-17A with pulmonary function and blood gas was analyzed. 【Results】 The levels of HDAC 2,pH and arterial partial pressure of oxygen (PaO2) in the COPD group were lower than those in the control group (P<0.05), and the levels of IL-17A and arterial partial pressure of carbon dioxide (PaCO2) were higher than those in the control group (P<0.05). The forced vital capacity (FVC), FEV1/FVC, maximum expiratory mid-flow (MMEF) and maximum expiratory flow (PEF) were significantly lower in the COPD group than in the control group (P<0.05). The level of HDAC2 in COPD patients was negatively correlated with PaCO2, and positively correlated with FEV1/FVC, FVC, MMEF, PEF, PH and PaO2 levels. The level of IL-17A was positively correlated with PaCO2 level, and negatively correlated with FEV1/FVC, FVC, MMEF, PEF, PH and PaO2 levels. 【Conclusion】 The level of HDAC2 is lower and level of IL-17A is higher in COPD patients. They are closely related to lung function and blood gas index. 2019 Vol. 36 (1): 103-105 [Abstract] ( 125 ) HTML (1 KB)  PDF  (0 KB)  ( 15 )

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