卡维地洛与比索洛尔对慢性阻塞性肺疾病合并心力衰竭患者心肺功能及生活质量的影响

doi:10.3969/j.issn.1671-7171.2019.01.019

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Abstract 【Objective】 To investigate the clinical efficacy of carvedilol and Bisoprolol in the treatment of patients with chronic obstructive pulmonary disease (COPD) complicated with heart failure (HF) and their effects on cardiopulmonary function and quality of life. 【Methods】 The clinical data of 138 patients with COPD combined with HF from February 2017 to January 2018 were analyzed retrospectively. According to the difference of treatment drugs, they were divided into control group and observation group with 69 cases in each group. Both groups were given routine medical treatment, the control group was treated with carvedilol and the observation group with Bisoprolol for 6 months. The clinical efficacy and heart and lung function of the two groups were compared. The quality of life (QOL) was evaluated by score of St. George's Respiratory questionnaire (SGRQ). 【Results】 The total effective rate was 92.8% (64/69) in the observation group and 81.2% (56/69) in the control group. The difference was statistically significant (χ²=4.089,P=0.043＜0.05). After 6 months of treatment, the vital capacity of (VC) in the control group was not significantly different from that before treatment (P>0.05), and the VC in the observation group was significantly higher than that before treatment (P<0.05). The resting heart rate, walking distance of 6 min and peak respiratory velocity (PEF) were significantly improved in the two groups after treatment, and the difference was statistically significant in the observation group than in the control group (P<0.05). After treatment, the activity ability, respiratory symptoms, disease impact score and total SGRQ score of the two groups were significantly lower than those of the control group (P<0.05), and those of the observation group were lower than those of the control group (P<0.05). The incidence of adverse reactions in the control group was 2.90% (2/69), which was lower than that in the observation group (4.35%). There was no significant difference between the two groups (χ²= 0.208,P<0.05). 【Conclusion】 Both carvedilol and bisoprolol could significantly improve the heart and lung function of COPD patients with HF, and improve their quality of life, but the efficacy of bisoprolol is better than that of carvedilol.

Key words： Pulmonary Disease Chronic Obstructive Heart Failure Carbazoles/TU Bisoprolol/TU

Received: 06 November 2018

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	ZHANG Hao
	WANG He
	GU Lei

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ZHANG Hao,WANG He,GU Lei. Effects of Carvedilol and Bisoprolol on Cardiopulmonary Function and Quality of Life in Patients with Chronic Obstructive Pulmonary Disease Complicated with Heart Failure[J]. JOURNAL OF CLINICAL RESEARCH, 2019, 36(1): 62-64.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2019.01.019 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2019/V36/I1/62

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