Abstract【Objective】 To investigate the levels and significance of soluble advanced glycation end product receptor (sRAGE) and Interleukin-32 (IL-32) in induced sputum and serum of patients with chronic obstructive pulmonary disease (COPD). 【Methods】 Eighty-nine COPD patients (COPD group) treated in our hospital from September 2017 to October 2018 were selected, including 33 acute exacerbation patients and 56 stable patients, 90 healthy volunteers were selected as control group, the induced sputum and serum levels of sRAGE and IL-32 were measured. At the same time, the pulmonary function index was detected.【Results】 The levels of sRAGE and IL-32 in induced sputum and serum in the observation group were significantly lower than those in the control group (P<0.05). The levels of induced sputum and serum sRAGE in the acute exacerbation group were significantly lower than those in the stable phase group (P<0.05). The level of IL-32 was significantly higher than that of the stable group (P<0.05). The percentage of forced expiratory volume (FEV1) / forced vital capacity (FVC)and FEV1 in the first second of acute exacerbation of COPD was significantly lower than that in the stable group (P<0.05). Induced sputum sRAGE and IL-32 were positively correlated with serum sRAGE and IL-32 (r=0.463, P<0.05, r=0.480, P<0.05); induced sputum sRAGE or IL-32 was negatively correlated with the percentage of FEV1/FVC and FEV1(r=-4.332, -4.402, P<0.05 or r=-450, -4.462, P<0.05).【Conclusion】 The levels of sRAGE and IL-32 in induced sputum and serum of COPD patients decreased, while IL-32 increased. The levels of sRAGE and IL-32 in induced sputum were closely related to liver function. The levels of sRAGE and IL-32 in induced sputum could reflect the pulmonary function of COPD patients.
HE Yu-yu,YANG Jing. Levels of sRAGE and IL-32 in Induced Sputum and Serum of COPD Patients and their Relationship with Pulmonary Function[J]. JOURNAL OF CLINICAL RESEARCH, 2019, 36(1): 86-88.
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