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Quick Search     Adv Search 2025 Vol. 42, No. 8 Published: 2025-08-26 Review and lecture Original Article          Original Article 1304 Comparison of Efficacy between Levodopa-Benserazide and Compound Carbidopa in the Treatment of Early Parkinson's Disease LI Xiaoxia, XIA Huan, YAN Run, et al DOI: 10.3969/j.issn.1671-7171.2025.08.003 【Objective】 To compare the efficacy and safety of levodopa-benserazide and compound carbidopa in the treatment of patients with early Parkinson's disease (PD).【Methods】 A total of 180 PD patients were randomly divided into the observation group and the control group, with 90 cases in each group. The control group was treated with levodopa-benserazide, while the observation group was treated with compound carbidopa. The efficacy, incidence of adverse reactions, and changes in scores of Part Ⅱ (daily activities, UPDRSⅡ) and Part Ⅲ (motor function, UPDRSⅢ) of the Unified Parkinson's Disease Rating Scale (UPDRS) and Parkinson's Disease Questionnaire-39 (PDQ-39) before and after treatment were compared between the two groups.【Results】After 12 weeks of treatment, there was no significant difference in the total effective rate between the two groups (P>0.05). From pre-treatment to 12 weeks after treatment, the scores of UPDRSⅡ, UPDRSⅢ, and PDQ-39 in both groups gradually decreased with the extension of time, and the differences at each time point were statistically significant (P<0.05). There were no significant differences in UPDRSⅡ, UPDRSⅢ, and PDQ-39 scores between the two groups before and at each time point after treatment (P>0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group (P<0.05).【Conclusion】The efficacy of levodopa-benserazide tablets and compound carbidopa in the treatment of early PD is comparable, however, compound carbidopa has higher safety. 2025 Vol. 42 (8): 1304-1306 [Abstract] ( 24 ) HTML (1 KB)  PDF (1276 KB)  ( 11 ) 1307 Clinical Application Value of 3D Bravo Combined with Cube Flair Enhanced Sequence in the Diagnosis of Small Cerebral Metastatic Tumors WU Junzi, LIU Fan, QIU Lingling, et al DOI: 10.3969/j.issn.1671-7171.2025.08.004 【Objective】To explore the clinical application value of 3D Bravo combined with Cube Flair enhanced sequence in the diagnosis of small cerebral metastatic tumors. 【Methods】Seventy-five tumor patients with cerebral metastases admitted to our hospital from January 2022 to March 2024 were selected. Cranial enhanced FSE T1WI, 3D Bravo, and Cube Flair scans were performed on a 1.5T magnetic resonance imaging scanner. The number of small cerebral metastatic tumor lesions detected by the three enhanced sequences and the 3D Bravo combined with Cube Flair sequence were counted respectively, and the diagnostic results were confirmed through two or more consecutive follow-up reviews. 【Results】A total of 420 small cerebral metastatic tumor lesions were found in 75 patients. Among them, 279 metastatic tumor lesions were found by conventional FSE T1WI enhancement, with a detection rate of 66.4%; 339 metastatic tumor lesions were found by the 3D Bravo enhanced sequence, with a detection rate of 80.7%; 377 metastatic tumor lesions were found by the Cube Flair enhanced sequence, with a detection rate of 89.8%; and 402 metastatic tumor lesions were found by the 3D Bravo combined with Cube Flair enhanced sequence, with a detection rate of 95.7%. There were statistically significant differences in the detection rates of small cerebral metastatic tumor lesions among the FSE T1WI, 3D Bravo, Cube Flair enhanced sequences and the 3D Bravo combined with Cube Flair enhanced sequence (P<0.05). The Cube Flair sequence had false-positive cases in the follow-up diagnosis of cystic cerebral metastatic tumors. 【Conclusion】The 3D Bravo combined with Cube Flair enhanced sequence can significantly improve the detection rate of small cerebral metastatic tumor lesions, especially in the diagnosis of small metastatic tumors in the superficial area of the brain, which has significant clinical application value and can be an alternative sequence to the conventional FSE T1WI enhanced sequence. 2025 Vol. 42 (8): 1307-1310 [Abstract] ( 19 ) HTML (1 KB)  PDF (1703 KB)  ( 9 ) 1311 Application of Personalized 3D-Printed Surgical Guide Plate-Assisted Hematoma Puncture and Drainage in Patients with Cerebral Hemorrhage ZHANG Haipo, HE Jianjun, SHE Xiaochun DOI: 10.3969/j.issn.1671-7171.2025.08.005 【Objective】 To investigate the efficacy of personalized 3D-printed surgical guide plate-assisted localization of hematoma puncture and drainage in patients with cerebral hemorrhage.【Methods】A total of 92 patients with cerebral hemorrhage were randomly divided into two groups, with 46 cases in each. The observation group underwent hematoma puncture and drainage with the assistance of a personalized 3D-printed surgical guide plate, while patients in the control group received CT-guided hematoma puncture and drainage. Surgical parameters, postoperative quality of life (measured by the SF-36 scale), neurological function [National Institutes of Health Stroke Scale (NIHSS) score], and incidence of postoperative rebleeding and secondary cerebral edema were compared between the two groups.【Results】The observation group had a shorter localization time and smaller residual hematoma volume compared with the control group (P<0.05). The rates of first-attempt puncture success, hematoma clearance, and correct drainage tube placement in the observation group were significantly higher than those in the control group (P<0.05). One week after surgery, the SF-36 total score in the observation group was higher than that in the control group (P<0.05), and at six months postoperatively, all SF-36 dimensions and total scores were significantly higher in the observation group (P<0.05). Six months after surgery, the NIHSS score of the observation group was lower than that of the control group (P<0.05). The incidences of postoperative rebleeding and secondary cerebral edema were significantly lower in the observation group (P<0.05).【Conclusion】Personalized 3D-printed surgical guide plate-assisted localization in hematoma puncture and drainage can effectively improve intraoperative localization accuracy, shorten localization time, increase first-attempt success rate, enhance neurological function and quality of life in patients with cerebral hemorrhage, and reduce postoperative complications. It is worthy of clinical application and promotion. 2025 Vol. 42 (8): 1311-1313 [Abstract] ( 15 ) HTML (1 KB)  PDF (1274 KB)  ( 9 ) 1314 Application Value of Problem-Oriented Nursing Intervention Program in Lung Cancer Patients Undergoing Chemotherapy LIU Ruimin, LIU Yalong, WANG Xiaobing, et al DOI: 10.3969/j.issn.1671-7171.2025.08.006 【Objective】To explore the application effect of a problem-oriented nursing intervention program in patients with lung cancer undergoing chemotherapy.【Methods】A total of 96 patients receiving chemotherapy for lung cancer were randomly divided into the observation group (receiving problem-oriented nursing intervention) and the control group (receiving routine nursing care), with 48 cases in each group. Pulmonary function, psychological resilience, and cancer-related fatigue were compared between the two groups on the day of admission and one day before discharge.【Results】 On the day of admission, there were no statistically significant differences between the two groups in terms of pulmonary function indicators, scores on the Connor-Davidson Resilience Scale (CD-RISC), or Cancer-Related Fatigue Scale (CRF) (P>0.05). One day before discharge, all pulmonary function indicators and CD-RISC scores in both groups were significantly improved compared to those on the day of admission (P< 0.05), while CRF scores were significantly decreased (P<0.05). Moreover, all indicators in the observation group were significantly better than those in the control group (P<0.05).【Conclusion】The implementation of a problem-oriented nursing intervention program can improve pulmonary function, psychological resilience, and cancer-related fatigue in patients, and is worthy of clinical promotion. 2025 Vol. 42 (8): 1314-1317 [Abstract] ( 24 ) HTML (1 KB)  PDF (1232 KB)  ( 12 ) 1318 Clinical and Chest HRCT Features of Rheumatoid Arthritis Patients Complicated with Mycobacterium Tuberculosis Infection XIAN Yaoyao, OU Jianghong, HUANG Wei, et al DOI: 10.3969/j.issn.1671-7171.2025.08.007 【Objective】To analyze the clinical and chest high-resolution computed tomography (HRCT) features of rheumatoid arthritis (RA) patients complicated with Mycobacterium tuberculosis infection.【Methods】The clinical data of 68 RA patients complicated with Mycobacterium tuberculosis infection who were diagnosed and treated in Changsha Central Hospital from August 2023 to August 2024 were retrospectively analyzed, and their clinical and chest HRCT features were analyzed. 【Results】The main clinical manifestations of the 68 RA patients complicated with Mycobacterium tuberculosis infection were cough (41.18%), joint pain (38.24%), fever (27.94%), weight loss and fatigue (8.82%). Among them, 44 cases (64.71%) had active tuberculosis, and 24 cases (35.29%) had latent Mycobacterium tuberculosis infection. In RA patients complicated with Mycobacterium tuberculosis infection, the infection was mainly in the lungs (pulmonary tuberculosis), accounting for 83.82% (57/68); extrapulmonary tuberculosis was mainly joint tuberculosis (5.88%, 4/68); the remaining 7 cases were Mycobacterium tuberculosis-infected patients without detectable infection foci. The HRCT of 57 patients with lung involvement showed that the lesions of 6 patients were located in the typical predilection sites of pulmonary tuberculosis (i.e., the apical-posterior segment of the upper lobe or the dorsal segment of the lower lobe), the lesions of 31 patients were scattered in both lungs, the lesions of 9 patients were located in the upper lobes of both lungs, the lesions of 4 patients were located in the middle-upper lobes of both lungs, the lesions of 2 patients were located in the lower lobes of both lungs, the lesions of 2 patients were located in the upper and lower lobes of the right lung, the lesions of 1 patient were located in the three lobes of the right lung, and the lesions of 2 patients were located in the upper and lower lobes of the left lung. The chest HRCT features of the 57 patients with lung involvement were diverse. Only 4 patients showed a single HRCT feature, while most patients presented multiple HRCT features. Among them, the proportion of patients with patchy shadows, fibro-cord shadows and nodular shadows was relatively high. 【Conclusion】RA patients complicated with Mycobacterium tuberculosis infection have diverse clinical manifestations, and the infection site is mainly in the lungs. In addition, patients with lung involvement show diverse features on chest HRCT, which are prone to misdiagnosis and missed diagnosis. 2025 Vol. 42 (8): 1318-1320 [Abstract] ( 26 ) HTML (1 KB)  PDF (1218 KB)  ( 9 ) 1321 Effect of Xuefu Zhuyu Pills on Pain and Sleep in Patients with Ovarian Cancer Undergoing Postoperative Chemotherapy FENG Guiyang, ZHANG Xiaotian, ZHANG Suping DOI: 10.3969/j.issn.1671-7171.2025.08.008 【Objective】 To explore the effect of Xuefu Zhuyu Pills combined with conventional treatment on pain, sleep quality, cancer-related fatigue, and emotional state in patients with ovarian cancer undergoing postoperative chemotherapy.【Methods】 A total of 86 patients with ovarian cancer receiving postoperative chemotherapy were randomly divided into two groups, with 43 cases in each group. All patients received conventional anti-tumor and symptomatic supportive treatment, and the observation group was additionally given Xuefu Zhuyu Pills. Changes in pain intensity [Visual Analogue Scale (VAS)], sleep quality [Pittsburgh Sleep Quality Index (PSQI)], cancer-related fatigue (Chinese version of the Revised Piper Fatigue Scale score), and emotional state [Self-rating Depression Scale (SDS) and Self-rating Anxiety Scale (SAS) scores] were compared between the two groups before and after intervention.【Results】 After 2 and 3 cycles of chemotherapy, the VAS scores in the observation group were significantly lower than those in the control group (P<0.05). After the end of chemotherapy, the PSQI score in the observation group was significantly lower than that in the control group (P<0.05). The scores of all items in the Piper Fatigue Scale, SDS, and SAS in both groups were lower than those before chemotherapy (P<0.05), and the observation group had lower scores than the control group (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05).【Conclusion】 Xuefu Zhuyu Pills combined with conventional treatment can effectively relieve pain, improve sleep quality, reduce cancer-related fatigue, and alleviate negative emotions such as depression and anxiety in patients with ovarian cancer during postoperative chemotherapy, which is worthy of clinical promotion and application. 2025 Vol. 42 (8): 1321-1323 [Abstract] ( 25 ) HTML (1 KB)  PDF (1276 KB)  ( 7 ) 1324 Application Effect of Painless Delivery Combined with Oxytocin and Artificial Rupture of Membranes for Induction of Labor in Full-Term Pregnant Women and its Impact on hs-CRP and PCT Levels CHEN Juan, LIU Yingjie DOI: 10.3969/j.issn.1671-7171.2025.08.009 【Objective】To explore the application effect of painless delivery combined with oxytocin and artificial rupture of membranes for induction of labor in full-term pregnant women and its impact on the levels of procalcitonin (PCT) and high-sensitivity C-reactive protein (hs-CRP). 【Methods】A total of 116 full-term pregnant women admitted to our hospital from January 2024 to January 2025 were selected and divided into a control group and an observation group according to the random number table method, with 58 cases in each group. The control group received painless delivery combined with oxytocin for labor induction, while the observation group received painless delivery combined with oxytocin and artificial rupture of membranes for labor induction. The labor induction effect, inflammatory index levels, and pregnancy outcomes were compared between the two groups. 【Results】The first stage, second stage, third stage, and total duration of labor in the observation group were significantly shorter than those in the control group, and the vaginal delivery rate was significantly higher than that in the control group (P<0.05). After delivery, the levels of hs-CRP and PCT in both groups were higher than those before delivery (P<0.05), but the levels of hs-CRP and PCT in the observation group were significantly lower than those in the control group (P<0.05). There were no statistically significant differences in the total incidence of adverse neonatal outcomes and maternal perinatal complications between the two groups (P>0.05). 【Conclusion】 For full-term pregnant women, labor induction with painless delivery combined with oxytocin and artificial rupture of membranes can shorten the labor process, improve the labor induction effect, and reduce the inflammatory response. 2025 Vol. 42 (8): 1324-1327 [Abstract] ( 23 ) HTML (1 KB)  PDF (1239 KB)  ( 3 ) 1328 Effects of Early Rehabilitation Training Combined with Low-Frequency Pulsed Electrical Stimulation on Limb Motor Function and Neurological Function in Stroke Patients with Hemiplegia SUN Lin DOI: 10.3969/j.issn.1671-7171.2025.08.010 【Objective】To explore the effects of early rehabilitation training combined with low-frequency pulsed electrical stimulation on limb motor function and neurological function in stroke patients with hemiplegia.【Methods】 A total of 108 stroke patients with hemiplegia were randomly divided into two groups, with 54 patients in each group. The control group received early rehabilitation training alone, while the observation group received early rehabilitation training combined with low-frequency pulsed electrical stimulation. After 12 weeks of intervention, therapeutic efficacy, surface electromyography (EMG) indicators of the hemiplegic lower limb, limb motor function [Stroke Rehabilitation Assessment of Movement (STREAM) score], neurological recovery [National Institutes of Health Stroke Scale (NIHSS) score], balance function [Berg Balance Scale (BBS) score], and quality of life [Stroke-Specific Quality of Life Scale (SS-QOL) score] were compared between the two groups before and after intervention.【Results】 The total effective treatment rate in the observation group was significantly higher than that in the control group (P<0.05). After the intervention, BBS, SS-QOL, and STREAM scores were significantly higher in the observation group compared to the control group (P<0.05), while NIHSS scores, maximal M-wave amplitude (Mmax), maximal H-wave amplitude (Hmax), and the Hmax/Mmax ratio in the hemiplegic lower limb were significantly lower than those in the control group (P<0.05).【Conclusion】 Early rehabilitation training combined with low-frequency pulsed electrical stimulation can significantly promote the recovery of limb motor and neurological functions in stroke patients with hemiplegia and effectively improve their quality of life. 2025 Vol. 42 (8): 1328-1331 [Abstract] ( 20 ) HTML (1 KB)  PDF (1233 KB)  ( 5 ) 1332 Effect of Irbesartan Combined with Dapagliflozin on Vascular Elasticity in Elderly Patients with Isolated Systolic Hypertension WANG Lu, CHEN Wei, ZHANG Yingfu DOI: 10.3969/j.issn.1671-7171.2025.08.011 【Objective】To explore the effect of irbesartan combined with dapagliflozin on vascular elasticity in elderly patients with isolated systolic hypertension (ISH).【Methods】A total of 158 elderly ISH patients admitted to our hospital from May 2022 to June 2024 were selected and divided into the observation group and the control group by the random number table method, with 79 patients in each group. The control group was treated with irbesartan, and the observation group was treated with irbesartan combined with dapagliflozin. Both groups were treated for 24 weeks. Blood pressure levels (24-hour average diastolic blood pressure, 24-hour average systolic blood pressure), vascular elasticity [carotid-femoral pulse wave velocity (cfPWV), ankle-brachial index (ABI), pressure-strain elastic modulus (Ep)], serum inflammatory factors [high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α)] and the incidence of adverse reactions were compared between the two groups before and after treatment.【Results】After treatment, the 24-hour average systolic blood pressure of both groups was lower than that before treatment, and that of the observation group was lower than that of the control group, with a statistically significant difference (P<0.05). There was no statistically significant difference in the 24-hour average diastolic blood pressure between the two groups (P>0.05). After treatment, cfPWV and Ep in the observation group were lower than those in the control group, and ABI was higher than that in the control group, with statistically significant differences (P<0.05). After treatment, the levels of serum hs-CRP and TNF-α in the observation group were lower than those in the control group, with statistically significant differences (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05).【Conclusion】Irbesartan combined with dapagliflozin can effectively improve the vascular elasticity of elderly ISH patients, significantly reduce systolic blood pressure, inhibit the inflammatory response, and has good safety, which has clinical promotion value. 2025 Vol. 42 (8): 1332-1334 [Abstract] ( 20 ) HTML (1 KB)  PDF (1284 KB)  ( 5 ) 1335 Clinical Efficacy of Sacubitril Valsartan Combined with Dapagliflozin in the Treatment of Coronary Heart Disease Complicated with Heart Failure LI Xiangna DOI: 10.3969/j.issn.1671-7171.2025.08.012 【Objective】To explore the clinical efficacy of sacubitril valsartan combined with dapagliflozin in the treatment of coronary heart disease (CHD) complicated with heart failure (HF). 【Methods】 A total of 82 patients with CHD complicated with HF admitted to our hospital from September 2020 to September 2023 were prospectively selected and divided into the observation group and the control group using a random number table method, with 41 patients in each group. The control group was treated with sacubitril valsartan, while the observation group was treated with sacubitril valsartan combined with dapagliflozin. The two groups were compared in terms of clinical efficacy, cardiac function indicators [left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF) and 6-minute walking distance (6MWD)], laboratory indicators [brain natriuretic peptide (BNP), high-sensitivity C-reactive protein (hs-CRP), nitric oxide (NO), endothelin-1 (ET-1)], 1-year readmission rate due to HF, and incidence of adverse reactions. 【Results】The total effective rate of the observation group was higher than that of the control group, with a statistically significant difference (P<0.05). After treatment, LVEF and 6MWD in both groups were higher than those before treatment, while LVEDD and LVESD were lower than those before treatment; LVEF and 6MWD in the observation group were higher than those in the control group, and LVEDD and LVESD were lower than those in the control group, with statistically significant differences (P<0.05). After treatment, the serum levels of BNP, hs-CRP, and ET-1 in both groups were lower than those before treatment, and the observation group had lower levels than the control group; the serum NO level in both groups was higher than that before treatment, and the observation group had a higher level than the control group, with statistically significant differences (P<0.05). The readmission rate due to HF in the observation group was lower than that in the control group, with a statistically significant difference (P=0.022). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】Sacubitril valsartan combined with dapagliflozin has a good clinical efficacy in the treatment of CHD complicated with HF. It improves patients' cardiac function and vascular endothelial function, inhibits inflammatory response, reduces the readmission rate of patients, and has good safety. 2025 Vol. 42 (8): 1335-1338 [Abstract] ( 16 ) HTML (1 KB)  PDF (1245 KB)  ( 2 ) 1339 Predictive Value of IL-6/STAT3 Signaling Pathway-Related Factors for Restenosis after Endovascular Therapy in Lower Extremity Arteriosclerosis Obliterans YANG Fan, ZHANG Yu, ZANG Sheng DOI: 10.3969/j.issn.1671-7171.2025.08.013 【Objective】To investigate the predictive value of interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway-related factors for restenosis after endovascular therapy in patients with lower extremity arteriosclerosis obliterans (LEASO). 【Methods】A total of 125 LEASO patients admitted to our hospital between January 2020 and January 2023 were enrolled. Patients were divided into poor-prognosis group (vascular restenosis >50%, n=41) and good-prognosis group (n=84) based on follow-up outcomes. Serum levels of IL-6, IL-6 receptor (IL-6R), Janus kinase 2 (JAK2), STAT3, vascular endothelial growth factor (VEGF), and nitric oxide (NO) were measured. Logistic regression analysis was used to identify risk factors for restenosis. Receiver operating characteristic (ROC) curves evaluated the predictive efficiency of the IL-6/STAT3 pathway. 【Results】 Poor-prognosis patients showed higher total cholesterol (TC) levels and lower ankle-brachial index (ABI) compared to good-prognosis patients (all P<0.05). Serum IL-6, IL-6R, JAK2, STAT3, and VEGF levels were significantly elevated, while NO levels were decreased in the poor-prognosis group (mean P<0.05). Multivariate analysis revealed high IL-6, IL-6R, JAK2, STAT3, VEGF levels and low NO levels as independent risk factors for restenosis (P<0.05). The ROC curve showed that the combined detection of IL-6, IL-6R, JAK2, and STAT3 had high diagnostic efficacy for the prognosis of patients with lower extremity arteriosclerosis obliterans who underwent interventional therapy.【Conclusion】IL-6/STAT3 pathway-related factors are closely associated with restenosis risk after endovascular therapy in LEASO patients. Elevated IL-6, IL-6R, JAK2, and STAT3 levels indicate higher restenosis probability. 2025 Vol. 42 (8): 1339-1342 [Abstract] ( 19 ) HTML (1 KB)  PDF (1338 KB)  ( 4 ) 1343 Effects of Bacterial Lysates Capsules Combined with Glucocorticoids on Th1/Th2 Cytokines and Pulmonary Function in Children with Bronchitis WANG Jing, GUAN Liujuan DOI: 10.3969/j.issn.1671-7171.2025.08.014 【Objective】To investigate the effects of bacterial lysates capsules combined with glucocorticoids on Th1/Th2 cytokines and pulmonary function in children with bronchitis. 【Methods】A total of 80 children with bronchitis admitted to our hospital from January 2018 to January 2021 were selected and divided into the observation group and the control group using a random number table method, with 40 cases in each group. Both groups received conventional antitussive, antiasthmatic, and anti-infection treatment after admission. The control group received budesonide suspension via nebulization. The observation group received oral bacterial lysates capsules in addition to the control group's treatment. The efficacy, disappearance time of clinical symptoms, and incidence of adverse reactions were compared between the two groups. The Th1/Th2 cytokines [interferon-γ (IFN-γ), interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-10 (IL-10)] and pulmonary function indicators [tidal breathing flow volume (TBFV), respiratory rate (RR), tidal volume (TV), ratio of time to peak tidal expiratory flow to total expiratory time (TPTEF/TE)] were compared before and after treatment. 【Results】The total effective rate in the observation group was 95.00% (38/40), significantly higher than that in the control group (80.00%, 32/40), with a statistically significant difference (P=0.043). The disappearance times of moist rales, cough, fever, and expectoration in the observation group were significantly shorter than those in the control group (P<0.05). Before treatment, there were no significant differences in IFN-γ, IL-2, IL-4, or IL-10 between the two groups (P>0.05). After treatment, the serum levels of IFN-γ, IL-2, and IL-10 in both groups were higher than those before treatment, while the IL-4 level was lower than before treatment. The observation group had higher serum levels of IFN-γ, IL-2, and IL-10 and a lower IL-4 level than the control group after treatment, with statistically significant differences (P<0.05). After treatment, the RR in both groups was lower than before treatment, while TV and TPTEF/TE were higher than before treatment. The observation group had a lower RR and higher TV and TPTEF/TE than the control group, with statistically significant differences (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P=0.288). 【Conclusion】Bacterial lysates capsules combined with glucocorticoids demonstrate good clinical efficacy in the treatment of pediatric bronchitis. They can effectively improve clinical symptoms, correct immune imbalance, enhance pulmonary function, and show good safety, indicating high application value. 2025 Vol. 42 (8): 1343-1346 [Abstract] ( 14 ) HTML (1 KB)  PDF (1247 KB)  ( 4 ) 1347 Application Effect of bedside Flexible Bronchoscope Lavage in Patients with Acute Ethanol Intoxication Complicated by Aspiration Pneumonia LIU Yuan, MA Ning DOI: 10.3969/j.issn.1671-7171.2025.08.015 【Objective】To explore the application effect of bedside flexible bronchoscope lavage in patients with acute ethanol intoxication complicated by aspiration pneumonia. 【Methods】A total of 108 patients with acute ethanol intoxication complicated by aspiration pneumonia admitted to our hospital from December 2020 to December 2023 were selected. According to the order of admission, they were divided into a control group and an observation group, with 54 cases in each group. The control group received conventional drug treatment, while the observation group was given additional bedside flexible bronchoscope lavage on the basis of the control group. The serum inflammatory factor levels and oxygen metabolism indicators of the two groups before and after treatment were compared. 【Results】After treatment, the levels of serum high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in the observation group were lower than those in the control group (P<0.05). After treatment, in both groups, oxygen delivery (DO2), oxygenation index (PaO2/FiO2), and arterial oxygen content (CaO2) increased, while oxygen consumption (VO2) and lactate (Lca) decreased; and the observation group was better than the control group (P<0.05). 【Conclusion】The application of bedside flexible bronchoscope lavage in patients with acute ethanol intoxication complicated by aspiration pneumonia can effectively reduce the inflammatory response and improve the patients' oxygen metabolism indicators. 2025 Vol. 42 (8): 1347-1349 [Abstract] ( 18 ) HTML (1 KB)  PDF (1216 KB)  ( 3 ) 1350 Clinical Efficacy of Yiqi Yangyin Decoction Assisted with Dapagliflozin and Metformin in the Treatment of Patients with Type 2 Diabetes Mellitus and its Impact on Vascular Endothelial Function LIU Shiwei, PANG Jianguo, ZHANG Lingguo DOI: 10.3969/j.issn.1671-7171.2025.08.016 【Objective】To explore the clinical efficacy of Yiqi Yangyin Decoction assisted with dapagliflozin and metformin in the treatment of patients with type 2 diabetes mellitus (T2DM) and its impact on vascular endothelial function. 【Methods】A total of 94 T2DM patients admitted to Fangcheng County Hospital of Traditional Chinese Medicine from February 2022 to February 2024 were selected and divided into an observation group and a control group by coin toss method, with 47 cases in each group. The control group received conventional treatment with dapagliflozin and metformin, while the observation group was given additional Yiqi Yangyin Decoction on the basis of the control group. The blood glucose indicators [fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), 2-hour postprandial blood glucose (2hPG)], TCM syndrome scores, vascular endothelial function indicators [adiponectin (ADPN), nitric oxide (NO), endothelin (ET)], and the occurrence of adverse reactions were compared between the two groups. 【Results】After treatment, the levels of FPG, HbA1c, 2hPG, ET and TCM syndrome scores in the observation group were lower than those in the control group (P<0.05), while the levels of ADPN and NO were higher than those in the control group (P<0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group (P<0.05).【Conclusion】Yiqi Yangyin Decoction assisted with dapagliflozin and metformin can effectively improve the blood glucose level and vascular endothelial function of T2DM patients, reduce the incidence of adverse reactions, improve the TCM syndrome score, and has high safety. 2025 Vol. 42 (8): 1350-1352 [Abstract] ( 19 ) HTML (1 KB)  PDF (1283 KB)  ( 3 ) 1353 Predictive Value of Scr, cys C, and BUN for Acute Kidney Injury in Severe Acute Pancreatitis YANG Yuchen, FANG Wei DOI: 10.3969/j.issn.1671-7171.2025.08.017 【Objective】To evaluate the predictive value of serum creatinine (Scr), cystatin C (cys C), and blood urea nitrogen (BUN) for acute kidney injury (AKI) in patients with severe acute pancreatitis (SAP).【Methods】 A total of 89 patients with SAP were enrolled and divided into two groups based on the occurrence of AKI: the AKI group (33 cases) and the non-AKI group (56 cases). Clinical data, Scr, cys C, and BUN levels were compared between the two groups. Univariate and multivariate logistic regression analyses were performed to identify risk factors for SAP complicated by AKI. Receiver operating characteristic (ROC) curves were used to analyze the predictive efficiency of Scr, cys C, and BUN.【Results】 Levels of Scr, cys C, and BUN were significantly higher in the AKI group compared to the non-AKI group (P<0.05). Univariate analysis showed that APACHE Ⅱ score, blood lactate, Ranson score, abdominal compartment syndrome (ACS), systemic inflammatory response syndrome (SIRS), shock, mechanical ventilation, C-reactive protein, procalcitonin, and serum calcium were associated with AKI occurrence (P<0.05). Multivariate logistic regression revealed that high APACHE Ⅱ score, high Ranson score, low serum calcium, elevated Scr, cys C, and BUN were independent risk factors for AKI in SAP patients (P<0.05). ROC curve analysis demonstrated that the combination of APACHE Ⅱ score, Ranson score, serum calcium, Scr, cys C, and BUN had a higher predictive value than any single indicator.【Conclusion】 Scr, cys C, and BUN levels are elevated in SAP patients with AKI. When the levels of Scr, cys C, and BUN combined with APACHE Ⅱ score, Ranson score, and serum calcium, they offer an even better predictive value for early identification of AKI in SAP. 2025 Vol. 42 (8): 1353-1356 [Abstract] ( 17 ) HTML (1 KB)  PDF (1278 KB)  ( 3 ) 1357 Preventive Value of Pneumatic Compression Therapy Combined with Enoxaparin Sodium Injection against Lower Extremity Deep Vein Thrombosis after Cesarean Section SHI Dongju, WANG Ning, HUO Huichan DOI: 10.3969/j.issn.1671-7171.2025.08.018 【Objective】To investigate the preventive value of pneumatic compression therapy combined with enoxaparin sodium injection against lower extremity deep vein thrombosis (DVT) after cesarean section. 【Methods】 A total of 200 pregnant women who underwent cesarean section at the First People's Hospital of the Xiangfu District ,Kaifeng from May 2021 to May 2024 were selected and divided into the control group (treated with enoxaparin sodium injection) and the observation group (treated with additional pneumatic compression therapy based on the control group) using a random number table method, with 100 cases in each group. Coagulation function indicators [D-dimer (D-D), prothrombin time (PT), activated partial thromboplastin time (APTT)], lower extremity venous blood flow velocity, and the incidence of DVT were compared between the two groups. 【Results】 After surgery, the D-D level in the observation group was lower than that in the control group, while PT and APTT were longer than those in the control group (P<0.05). The blood flow velocities in the deep femoral vein, popliteal vein, and posterior tibial vein in the observation group were higher than those in the control group (P<0.05). The incidence of DVT in the observation group was lower than that in the control group (P<0.05). 【Conclusion】Pneumatic compression therapy combined with enoxaparin sodium injection can effectively improve coagulation function and hemodynamic indicators, and reduce the incidence of DVT after cesarean section. 2025 Vol. 42 (8): 1357-1359 [Abstract] ( 20 ) HTML (1 KB)  PDF (1213 KB)  ( 3 ) 1360 Efficacy of Different Doses of Perindopril in the Treatment of Patients with Ischemic Heart Failure and its Effects on Cardiac Function and Serum Indicators LI Furong, YU Weiren, PI Shufang DOI: 10.3969/j.issn.1671-7171.2025.08.019 【Objective】To investigate the efficacy of different doses of perindopril in the treatment of patients with ischemic heart failure and its effects on cardiac function and serum indicators. 【Methods】The clinical data of 100 patients with ischemic heart failure diagnosed and treated at Tianjin Jinnan District Xikang Hospital from April 2019 to April 2022 were retrospectively analyzed. According to the dosage of perindopril, the patients were divided into a high-dose group (treated with a high dose of perindopril, n=52) and a low-dose group (treated with a low dose of perindopril, n=48). The treatment efficacy, incidence of adverse reactions, serum levels of neutrophil gelatinase-associated lipocalin (NGAL) and N-terminal pro-brain natriuretic peptide (NT-proBNP), left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESD), and left ventricular end-diastolic diameter (LVEDD) were compared between the two groups before and after treatment. 【Results】The total effective rate in the high-dose group was 94.23%, significantly higher than that in the low-dose group (79.17%), and the difference was statistically significant (P<0.05). After treatment, the serum levels of NGAL and NT-proBNP in both groups were significantly lower than those before treatment, and the levels in the high-dose group were lower than those in the low-dose group (P<0.05). After treatment, the LVEF in both groups was significantly higher than that before treatment, and it was higher in the high-dose group than in the low-dose group; the LVESD and LVEDD were significantly shorter than those before treatment, and they were shorter in the high-dose group than in the low-dose group (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 High-dose perindopril is more effective in treating patients with ischemic heart failure, significantly improving serum levels of NGAL and NT-proBNP, as well as cardiac function. 2025 Vol. 42 (8): 1360-1362 [Abstract] ( 15 ) HTML (1 KB)  PDF (1278 KB)  ( 4 ) 1363 Relationship between Umbilical Cord Blood Vitamin D Levels and Fetal Brain Development Abnormalities in Pregnant Women with Gestational Diabetes Mellitus and the Intervention Effect of Vitamin D3 DING Qing, WU Xiaojing, LI Bingfei DOI: 10.3969/j.issn.1671-7171.2025.08.020 【Objective】To investigate the relationship between umbilical cord blood vitamin D levels and fetal brain development abnormalities in pregnant women with gestational diabetes mellitus (GDM), as well as the intervention effect of vitamin D3.【Methods】 A total of 80 GDM pregnant women diagnosed and treated in our hospital from January 2023 to January 2025 were selected and divided into an observation group and a control group according to the random number table method, with 40 cases in each group. The control group received treatment according to conventional obstetric care and GDM management guidelines, while the observation group received additional vitamin D3 supplementation based on the control group's treatment. The vitamin D levels in maternal blood and umbilical cord blood, fetal brain development [assessed by the Neonatal 20-Item Behavioral Neurological Assessment (NBNA) score and intracranial ultrasound indicators], and pregnancy outcomes were compared between the two groups. The correlation between vitamin D levels and fetal brain development was analyzed. 【Results】The vitamin D levels in maternal blood and umbilical cord blood in the observation group were significantly higher than those in the control group (P<0.05). The NBNA score of newborns in the observation group was higher than that in the control group, and the corpus callosum length, sagittal length of the cerebellar vermis, and pancreatic islet circumference were significantly longer than those in the control group (P<0.05). The proportion of newborns with an Apgar score ≤7 in the observation group was significantly higher than that in the control group (P<0.05). Vitamin D levels in maternal blood and umbilical cord blood were significantly correlated with the NBNA score and intracranial ultrasound abnormality rate of newborns (P<0.05). 【Conclusion】 Umbilical cord blood vitamin D levels in GDM pregnant women are significantly correlated with fetal brain development abnormalities. Vitamin D3 supplementation can effectively increase umbilical cord blood vitamin D levels in GDM pregnant women and may positively influence the improvement of fetal brain development. 2025 Vol. 42 (8): 1363-1366 [Abstract] ( 22 ) HTML (1 KB)  PDF (1238 KB)  ( 5 ) 1367 Predictive Value of Combined Detection of D-Dimer and NLR for Prognosis of Community-Acquired Bacterial Liver Abscess DONG Jin, SHAN Fuqiang, LI Huimin DOI: 10.3969/j.issn.1671-7171.2025.08.021 【Objective】To investigate the prognostic value of combined detection of plasma D-dimer (D-D) and peripheral blood neutrophil-to-lymphocyte ratio (NLR) in patients with community-acquired bacterial liver abscess (CABHA).【Methods】 Plasma D-D and peripheral blood NLR levels were measured in 94 CABHA patients. Based on 6-month follow-up outcomes, patients were divided into a good prognosis group and a poor prognosis group. Factors influencing prognosis were analyzed, and the predictive value of combined D-D and NLR detection was evaluated.【Results】Among the 94 patients, 75 (79.79%) had good prognosis and 19 (20.21%) had poor prognosis. Logistic regression analysis showed that a history of diabetes, multiple abscesses, maximum abscess diameter >5 cm, and elevated serum D-D and NLR levels were all risk factors for the poor prognosis in CABHA patients (P<0.05). Receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) for predicting prognosis using D-D alone, NLR alone, and combined both D-D and NLR detection was 0.734, 0.726, and 0.797, respectively, with combined detection showing significantly better predictive performance than single indicator(Z=7.104, P<0.05).【Conclusion】 Plasma D-D and peripheral blood NLR levels can be used to evaluate the prognosis of patients with CABHA. 2025 Vol. 42 (8): 1367-1369 [Abstract] ( 18 ) HTML (1 KB)  PDF (1238 KB)  ( 3 ) 1370 Clinical Efficacy of Shensong Yangxin Capsules Combined with Deanxit in the Treatment of Patients with Depression after PCI for Coronary Heart Disease QI Yanwei DOI: 10.3969/j.issn.1671-7171.2025.08.022 【Objective】To explore the clinical efficacy of Shensong Yangxin Capsules combined with Deanxit in the treatment of patients with depression after percutaneous coronary intervention (PCI) for coronary heart disease (CHD). 【Methods】A total of 102 patients with depression after PCI for CHD admitted to our hospital from June 2022 to December 2024 were selected. According to the random number table method, they were divided into the observation group (treated with Deanxit + Shensong Yangxin Capsules) and the control group (treated with Deanxit), with 51 cases in each group. After 3 months of treatment, the TCM syndrome scores, depression status, and clinical efficacy of the two groups were evaluated and compared. The neurotransmitter factors [brain-derived neurotrophic factor (BDNF), 5-hydroxytryptamine (5-HT)], cardiac function indicators [left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF)], and the occurrence of adverse reactions were also compared between the two groups. 【Results】The total clinical effective rate of the observation group was 94.12% (48/51), which was higher than 80.39% (41/51) of the control group, and the difference was statistically significant (P<0.05). At 1 month and 3 months after treatment, the serum levels of BDNF and 5-HT in both groups were higher than those before treatment, and the observation group was higher than the control group, with statistically significant differences (P<0.05). At 1 month and 3 months after treatment, the LVEF of both groups was higher than that before treatment, and the LVEDD was lower than that before treatment; the LVEF of the observation group was higher than that of the control group, and the LVEDD was lower than that of the control group, with statistically significant differences (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】Shensong Yangxin Capsules combined with Deanxit has a good clinical efficacy in the treatment of depression after PCI for CHD. It can significantly improve the clinical symptoms of patients, enhance the levels of neurotransmitter factors and cardiac function, and has good safety. 2025 Vol. 42 (8): 1370-1373 [Abstract] ( 14 ) HTML (1 KB)  PDF (1305 KB)  ( 3 ) 1374 Application Effect of Functional Rehabilitation Training Based on System CHANGE Model in Patients after Ankle Fracture Surgery ZHANG Xuejun, CHEN Liangchao, LI Haoyue DOI: 10.3969/j.issn.1671-7171.2025.08.023 【Objective】To explore the application effect of functional rehabilitation training based on the SystemCHANGE model in patients after ankle fracture surgery. 【Methods】Eighty-two patients with ankle fractures treated in our hospital from May 2019 to June 2022 were selected and divided into an observation group (receiving functional rehabilitation training under the SystemCHANGE model) and a control group (receiving conventional rehabilitation intervention) via the random number table method, with 41 patients in each group. Ankle joint function, pain condition, rehabilitation training compliance, and activities of daily living (ADL) ability were compared between the two groups. 【Results】 After intervention, ankle joint function scores in both groups improved compared to baseline (P<0.05), with the observation group demonstrating significantly higher scores than the control group (P<0.05). Seven days after intervention, Visual Analogue Scale (VAS) scores decreased in both groups (P<0.05), with the observation group showing lower scores than the control group (P<0.05). Rehabilitation training compliance in the observation group was 92.68%, significantly higher than 75.61% in the control group (P<0.05). At discharge, Barthel Index scores increased in both groups compared to admission (P<0.05), with the observation group achieving higher scores than the control group (P<0.05).【Conclusion】Functional rehabilitation training based on the SystemCHANGE model effectively improves ankle joint function, reduces pain, enhances ADL ability, and increases rehabilitation compliance in patients after ankle fracture surgery. 2025 Vol. 42 (8): 1374-1377 [Abstract] ( 17 ) HTML (1 KB)  PDF (1241 KB)  ( 4 ) 1378 Application Effect of Catheter-Directed Thrombolysis Combined with Intermittent Pulsed Anticoagulation in Patients with Acute Lower Extremity Deep Vein Thrombosis LIU Zhijie DOI: 10.3969/j.issn.1671-7171.2025.08.024 【Objective】To investigate the application effect of catheter-directed thrombolysis combined with intermittent pulsed heparin anticoagulation in acute lower extremity deep vein thrombosis (DVT). 【Methods】 A total of 102 patients with acute lower extremity DVT admitted to our hospital from May 2023 to May 2024 were selected and divided into the control group (receiving conventional thrombolytic therapy) and the observation group (receiving continuous 24-hour pump infusion of urokinase combined with intermittent pulsed heparin irrigation) using a random number table method, with 51 patients in each group. The clinical efficacy, swelling relief degree, venous patency, pain level, laboratory indicators [activated partial thromboplastin time (APTT), fibrinogen (Fib), D-dimer (D-D) detected by chemiluminescence method], incidence of adverse reactions, and recurrence were compared between the two groups. 【Results】The clinical effective rate in the observation group was 96.08% (49/51), which was higher than that in the control group (80.39%, 41/51), with a statistically significant difference (χ2=6.044, P<0.05). After treatment, the swelling relief degree in both groups was higher than that before treatment, and it was higher in the observation group than in the control group (P<0.05). The venous patency and VAS scores in both groups were lower than those before treatment, and they were lower in the observation group than in the control group (P<0.05). After treatment, the APTT in both groups was longer than that before treatment, and it was longer in the observation group than in the control group (P<0.05). The levels of Fib, D-D, and CRP were lower than those before treatment, and they were lower in the observation group than in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). The postoperative thrombus clearance rate and 1-year vascular patency rate in the observation group were higher than those in the control group, while the 1-year recurrence rate was lower than that in the control group, with statistically significant differences (P<0.05). 【Conclusion】Catheter-directed thrombolysis combined with intermittent pulsed heparin anticoagulation demonstrates good application effects in acute lower extremity DVT. It helps improve venous patency, alleviate lower extremity swelling, reduce thrombosis recurrence rate, and shows favorable clinical outcomes. 2025 Vol. 42 (8): 1378-1381 [Abstract] ( 16 ) HTML (1 KB)  PDF (1238 KB)  ( 4 ) 1382 Correlation of Serum Biomarker Levels of Endothelial Dysfunction with Cerebrovascular Reactivity in Patients with Chronic Hepatitis C LU Qiao, YANG Han, LIU Jianying DOI: 10.3969/j.issn.1671-7171.2025.08.025 【Objective】 To investigate the levels of serum biomarkers of endothelial dysfunction-intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and vascular endothelial growth factor A (VEGF-A) in patients with chronic hepatitis C (CHC), and their correlation with cerebrovascular reactivity.【Methods】 A total of 50 CHC patients treated in our hospital were included in the hepatitis group, while 30 healthy blood donors were selected as the control group. Levels of ICAM-1, VCAM-1, VEGF-A, and breath-holding index (BHI) were compared between the two groups. Pearson correlation analysis was used to evaluate the association of ICAM-1, VCAM-1 and VEGF-A levels with cerebrovascular reactivity.【Results】 Levels of ICAM-1 and VCAM-1 were significantly higher in the hepatitis group than in the control group (P<0.05), while VEGF-A and BHI in the hepatitis group were significantly lower than those in the control group (P<0.05). Pearson correlation analysis showed that ICAM-1 and VCAM-1 were significantly negatively correlated with BHI in the hepatitis group (r=-0.584 and -0.670, respectively; both P<0.05), whereas VEGF-A was significantly positively correlated with BHI (r=0.604, P<0.05). In the control group, no significant correlation was observed between BHI and levels of ICAM-1, VCAM-1 andVEGF-A (all P>0.05).【Conclusion】 Patients with CHC have significant endothelial dysfunction showing increased serum ICAM-1 and VCAM-1 levels and decreased VEGF-A level, which are significantly correlated with cerebrovascular reactivity as measured by BHI. 2025 Vol. 42 (8): 1382-1384 [Abstract] ( 19 ) HTML (1 KB)  PDF (1221 KB)  ( 3 ) 1385 Comparison of the Diagnostic Value of Radioimmunoassay and Chemiluminescence Immunoassay in Thyroid Tumors CHANG Hui, SHI Zhipeng, DONG Shuxiao DOI: 10.3969/j.issn.1671-7171.2025.08.026 【Objective】 To compare the diagnostic value of radioimmunoassay and chemiluminescence immunoassay in thyroid tumors.【Methods】 A total of 76 patients with suspected of having thyroid tumors were included in the study. The pathological diagnosis was served as the gold standard. The levels of thyroglobulin detected by both radioimmunoassay and chemiluminescence immunoassay were compared. The diagnostic performance of the two methods was evaluated using receiver operating characteristic (ROC) curve analysis.【Results】 The number of thyroglobulin-positive cases, thyroglobulin antibody levels, and thyroglobulin levels detected by chemiluminescence immunoassay were all significantly higher than those detected by radioimmunoassay (P<0.05). The diagnostic concordance rate between chemiluminescence immunoassay and pathological diagnosis was 92.11% (70/76), which was significantly higher than that of radioimmunoassay (76.32%, 58/76); And the difference was statistically significant (P<0.05). ROC curve analysis showed that the area under the curve (AUC), sensitivity, and specificity of chemiluminescence immunoassay were significantly higher than those of radioimmunoassay (P<0.05).【Conclusion】 Compared to radioimmunoassay, chemiluminescence immunoassay has higher clinical value and better diagnostic performance in the diagnosis of thyroid tumors, providing more reliable evidence for clinical diagnosis and treatment. 2025 Vol. 42 (8): 1385-1387 [Abstract] ( 20 ) HTML (1 KB)  PDF (1253 KB)  ( 4 ) 1388 Therapeutic Effect of Buyang Huanwu Decoction Combined with Edaravone Dexborneol Injection in the Treatment of Acute Cerebral Infarction ZHU Tengxi, BAO Dangzhen DOI: 10.3969/j.issn.1671-7171.2025.08.027 【Objective】 To investigate the clinical efficacy of Buyang Huanwu Decoction combined with edaravone dexborneol injection in the treatment of acute cerebral infarction (ACI).【Methods】A total of 90 ACI patients were randomly divided into the control group and the observation group, with 45 cases in each group. The control group received edaravone dexborneol injection, while the observation group received BYHWD in addition to the same treatment as the control group. Changes in carotid intima-media thickness (IMT), plaque area, Traditional Chinese Medicine (TCM) syndrome score, neurological deficit [National Institutes of Health Stroke Scale (NIHSS) score], quality of life [Modified Rankin Scale (MRS) score], and serum levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) and neuron-specific enolase (NSE) were compared between the two groups before and after treatment.【Results】 After treatment, the observation group showed significantly lower carotid IMT, plaque area, TCM syndrome score, NIHSS score, mRS score, Lp-PLA2, and NSE levels compared to the control group (P<0.05).【Conclusion】Buyang Huanwu Decoction combined with edaravone dexborneol injection can effectively alleviate arterial lesions, improve TCM symptoms and neurological function, enhance quality of life, and reduce serum Lp-PLA2 and NSE levels in ACI patients, making it worthy of clinical promotion. 2025 Vol. 42 (8): 1388-1390 [Abstract] ( 18 ) HTML (1 KB)  PDF (1273 KB)  ( 5 ) 1391 Application Effect of Graded Nursing Intervention Guided by the PASE in Elderly Patients with COPD MA Bingbing, CUI Hongyan DOI: 10.3969/j.issn.1671-7171.2025.08.028 【Objective】To investigate the application effect of a graded nursing intervention guided by the Chinese version of the Physical Activity Scale for the Elderly (PASE) in elderly patients with chronic obstructive pulmonary disease (COPD).【Methods】A total of 72 elderly COPD patients who visited our hospital from March 2021 to October 2023 were selected and divided into a control group (receiving routine medical nursing) and an observation group (receiving PASE-guided graded nursing intervention) using a random number table method, with 36 patients in each group. Both groups received continuous intervention for 12 weeks. The length of hospital stay, total incidence of complications, pulmonary function [vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in the first second as a percentage of predicted value (FEV1% pred), and the ratio of FEV1 to FVC (FEV1/FVC)], quality of life [St. George's Respiratory Questionnaire (SGRQ) score], patient compliance, and nursing satisfaction were compared between the two groups. 【Results】After the intervention, the length of hospital stay in the observation group was significantly shorter than that in the control group, and the total incidence of complications was significantly lower than that in the control group, with statistically significant differences (P<0.05). After the intervention, the VC, FVC, and FEV1/FVC in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). After the intervention, the SGRQ score in the observation group was lower than that in the control group, while patient compliance and nursing satisfaction were higher than those in the control group, with statistically significant differences (P<0.05). 【Conclusion】The graded nursing intervention guided by the PASE can effectively shorten the hospital stay of elderly COPD patients, improve pulmonary function, enhance patient compliance and nursing satisfaction, and reduce the incidence of complications. It is worthy of clinical promotion. 2025 Vol. 42 (8): 1391-1394 [Abstract] ( 18 ) HTML (1 KB)  PDF (1234 KB)  ( 3 ) 1395 The Effect of Amlodipine Combined with Atorvastatin Calcium Tablets on Efficacy, Blood Lipids and Cardiac Function in Elderly Patients with Hypertension Complicated by Coronary Heart Disease SHI kelian, CHEN Haipeng DOI: 10.3969/j.issn.1671-7171.2025.08.029 【Objective】To explore the effect of amlodipine combined with atorvastatin calcium tablets on clinical efficacy, blood lipids and cardiac function in elderly patients with hypertension complicated by coronary heart disease. 【Methods】A total of 68 elderly patients with hypertension complicated by coronary heart disease admitted to Houji Town Health Center of Wuyang County, Luohe City from September 2022 to September 2024 were selected. They were divided into the control group and the observation group by random number table method, with 34 cases in each group. The therapeutic effect, blood pressure, blood lipid indexes [serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C)] and cardiac function indexes [left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD)] were compared between the two groups. 【Results】The clinical effective rate of the observation group was 94.12% (32/34), which was higher than 73.53% (25/34) of the control group, and the difference was statistically significant (χ2=5.314, P<0.05). After treatment, the systolic blood pressure and diastolic blood pressure of both groups were lower than those before treatment, and the observation group was lower than the control group, with statistically significant differences (P<0.05). After treatment, the serum levels of TC, TG and LDL-C in both groups were lower than those before treatment, while the HDL-C level was higher than that before treatment; compared with the control group, the observation group had lower serum TC, TG and LDL-C levels and higher HDL-C level, with statistically significant differences (P<0.05). After treatment, the LVEF of both groups was higher than that before treatment, and the LVESD and LVEDD were lower than those before treatment; the observation group had higher LVEF and lower LVESD and LVEDD than the control group, with statistically significant differences (P<0.05). 【Conclusion】 Amlodipine combined with atorvastatin calcium tablets can effectively improve blood pressure, blood lipids and cardiac function in elderly patients with hypertension complicated by coronary heart disease, and has good clinical application value. 2025 Vol. 42 (8): 1395-1397 [Abstract] ( 15 ) HTML (1 KB)  PDF (1280 KB)  ( 4 ) 1398 Efficacy of Two Different Approaches of Hip Arthroplasty in the Treatment of Patients with Ankylosing Spondylitis Complicated by Hip Joint Lesions and their Impact on Serum Inflammatory Factor Levels HUANG Fei DOI: 10.3969/j.issn.1671-7171.2025.08.030 【Objective】To explore the efficacy of two different approaches of hip arthroplasty in the treatment of patients with ankylosing spondylitis (AS) complicated by hip joint lesions and their impact on serum inflammatory factor levels. 【Methods】A total of 86 patients with AS complicated by hip joint lesions who underwent hip arthroplasty in our hospital from January 2020 to January 2024 were selected. According to the different surgical approaches, they were divided into the observation group (anterior approach) and the control group (posterolateral approach), with 43 cases in each group. The Visual Analogue Scale (VAS) score, hip function score [Harris Hip Score (HHS) system], Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, serum inflammatory factor [interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)] levels, and hip abduction and flexion angles were compared between the two groups before and after treatment. 【Results】After treatment, the WOMAC score and VAS score of the observation group were lower than those of the control group (P<0.05). After treatment, the levels of inflammatory factors in the observation group were lower than those in the control group, and the HHS score was higher than that in the control group (P<0.05). At 1 month and 3 months after treatment, the hip abduction angle and hip flexion angle of the observation group were larger than those of the control group, and the differences were statistically significant (P<0.05). 【Conclusion】Compared with posterolateral approach hip arthroplasty, anterior approach hip arthroplasty has a more significant effect on improving hip function, reducing pain scores and lowering serum inflammatory factor levels in patients with AS complicated by hip joint lesions. 2025 Vol. 42 (8): 1398-1401 [Abstract] ( 15 ) HTML (1 KB)  PDF (1234 KB)  ( 3 )

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