HDL-C联合RDW对脓毒症严重程度及预后的评估价值<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2025.06.009

Abstract
Figure/Table
References (0)
Related Citation (15)

Download: PDF (1283 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To explore the clinical value of high-density lipoprotein cholesterol (HDL-C) combined with red blood cell distribution width (RDW) in evaluating the severity and prognosis of sepsis. 【Methods】 A total of 103 sepsis patients admitted to our hospital from January 2020 to January 2024 were selected and divided into sepsis group (n=42), severe sepsis group (n=36), and septic shock group (n=25) according to the severity of illness, and into survival group (n=60) and death group (n=43) according to prognosis. HDL-C and RDW levels were compared among patients with different severities, the correlation between HDL-C, RDW and sepsis severity was analyzed, clinical data and HDL-C, RDW levels were compared between survival and death groups, and related factors affecting death in sepsis patients were analyzed. 【Results】HDL-C levels gradually decreased and RDW levels gradually increased in the sepsis group, severe sepsis group, and septic shock group, with statistically significant differences (P<0.05). HDL-C was negatively correlated with sepsis severity (P<0.05), while RDW was positively correlated with sepsis severity (P<0.05). HDL-C level in the death group was lower than that in the survival group, and RDW level was higher than that in the survival group, with statistically significant differences (P<0.05). The death group had higher C-reactive protein (CRP), sequential organ failure assessment(SOFA) score, Interleukin-35(IL-35), acute physiology and chronic health evaluation Ⅱ score(APACHEⅡ score), white blood cell count, aspartate aminotransferase (AST), serum creatinine (Scr), and procalcitonin (PCT) than the survival group, with statistically significant differences (P<0.05). Multivariate Logistic regression analysis showed that APACHEⅡ, HDL-C, RDW, and SOFA score were related factors affecting the prognosis of sepsis patients (P<0.05). ROC curve analysis showed that the AUC values of RDW, HDL-C, and their combination for predicting death in sepsis patients were 0.824, 0.805, and 0.899 (P<0.05), respectively, and the combined AUC value was higher (P<0.05). 【Conclusion】HDL-C and RDW are closely related to the prognosis and severity of sepsis patients, and their combination has a higher efficacy in predicting patient prognosis.

Key words： Sepsis Cholesterol, HDL Erythrocyte Indices Prognosis

Received: 07 May 2024

PACS:

R631.1

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	XU Bo

Cite this article:

XU Bo. Value Analysis of HDL-C Combined with RDW in Evaluating the Severity and Prognosis of Sepsis[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(6): 940-943.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.06.009 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I6/940

[1] CHIU C, LEGRAND M. Epidemiology of sepsis and septic shock[J].Curr Opin Anaesthesiol,2021,34(2):71-76.
[2] MENON K, SCHLAPBACH L J, AKECH S, et al. Criteria for pediatric sepsis-A systematic review and meta-analysis by the pediatric sepsis definition taskforce[J].Crit Care Med,2022,50(1):21-36.
[3] BALDIRA J, RUIZ-RODRIGUEZ J C, RUIZ-SANMARTIN A, et al. Use of biomarkers to improve 28-day mortality stratification in patients with sepsis and SOFA≤6[J].Biomedicines,2023,11(8):2149.
[4] DE GEEST B, MISHRA M. Impact of high-density lipoproteins on sepsis[J].Int J Mol Sci,2022,23(21):12965.
[5] LIU Z Y, JIANG H Z, WANG L, et al. Diagnostic accuracy of red blood cell distribution width for neonatal sepsis[J].Minerva Pediatr (Torino),2022,74(2):202-212.
[6] 中国医师协会急诊医师分会,中国研究型医院学会休克与脓毒症专业委员会. 中国脓毒症/脓毒性休克急诊治疗指南(2018)[J].中国急救医学,2018,38(9):741-756.
[7] BULUT O, AKCAKAYA A, BULUT N, et al. Elevated red cell distribution width as a useful marker in neonatal sepsis[J].J Pediatr Hematol Oncol,2021,43(5):180-185.
[8] ROHATGI A, WESTERTERP M, VON ECKARDSTEIN A, et al. HDL in the 21st century: a multifunctional roadmap for future HDL research[J].Circulation,2021,143(23):2293-2309.
[9] CHANG L, CHEN X L, LIAN C. The association between the non-HDL-cholesterol to HDL-cholesterol ratio and 28-day mortality in sepsis patients: a cohort study[J].Sci Rep,2022,12(1):3476.
[10] BARKER G, WINER J R, GUIRGIS F W, et al. HDL and persistent inflammation immunosuppression and catabolism syndrome[J].Curr Opin Lipidol,2021,32(5):315-322.
[11] LAI H H, WU G S, ZHONG Y, et al. Red blood cell distribution width improves the prediction of 28-day mortality for patients with sepsis-induced acute kidney injury: a retrospective analysis from MIMIC-IV database using propensity score matching[J].J Intensive Med,2023,3(3):275-282.
[12] LIU G, JIANG L, KERCHBERGER V E, et al. The relationship between high density lipoprotein cholesterol and sepsis: a clinical and genetic approach[J].Clin Transl Sci,2023,16(3):489-501.
[13] GUIRGIS F W, LEEUWENBURGH C, MOLDAWER L, et al. Lipid and lipoprotein predictors of functional outcomes and long-term mortality after surgical sepsis[J].Ann Intensive Care,2021,11(1):82.
[14] 杨晨,郭蕾,黄方,等. 红细胞分布宽度对老年脓毒症患者临床转归的评估价值[J].解放军医学杂志,2021,46(5):474-480.
[15] 白新凤,徐梅先,郭芳,等. 红细胞及血小板参数对脓毒症患儿预后的预测价值[J].中国急救医学,2021,41(8):693-697.