聚乙二醇干扰素α-2a联合富马酸替诺福韦二吡呋酯治疗HBeAg阳性初治慢性乙型肝炎患者的临床效果

doi:10.3969/j.issn.1671-7171.2025.06.025

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Abstract 【Objective】To investigate the clinical efficacy of pegylated interferon α-2a combined with tenofovir disoproxil fumarate in the treatment of hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) patients. 【Methods】A total of 76 newly diagnosed CHB patients with HBeAg positivity admitted to our hospital from June 2021 to May 2024 were randomly divided into the observation group and the control group using a random number table method, with 38 patients in each group. The control group was treated with tenofovir disoproxil fumarate, while the observation group was treated with pegylated interferon alpha-2a in addition to the control group. Both groups were treated continuously for 48 weeks. The clinical efficacy [negative conversion rate of hepatitis B virus load (HBV-DNA), virological response rate, negative conversion rate of HBeAg, serological conversion rate of HBsAg] and adverse drug reactions of the two groups were compared, and the levels of HBV-DNA, HBeAg, ALT, liver fibrosis indicators [hyaluronic acid (HA), laminin (LN), type Ⅲ procollagen (PC Ⅲ), type Ⅳ collagen (C-Ⅳ)], inflammatory factors [interleukin-17 (IL-17), interleukin-4 (IL-4), interferon-α(IFN-α)] before and after treatment were compared in the two groups. 【Results】The HBV-DNA negative conversion rate, HBeAg negative conversion rate, virological response rate, and HBsAg seroconversion rate in the observation group were significantly higher than those in the control group, and the differences were statistically significant (P<0.05). After treatment, the levels of HBV-DNA, HBeAg, and ALT in both groups were lower than those before treatment, and the levels of HBV-DNA, HBeAg, and ALT of the observation group was even lower than those of the control group, with statistical significance (P<0.05). After treatment, the levels of HA, LN, PC Ⅲ, C-Ⅳ in both groups were lower than those before treatment, and the levels of HA, LN, PC Ⅲ, C-Ⅳof the observation group was lower than those of the control group, with statistical significance (P<0.05). After treatment, IL-17 and IL-4 levels in both groups were lower than those before treatment, while IFN-α levels were higher than that before treatment, with statistically significant differences (P<0.05); The levels of IL-17 and IL-4 in the observation group were lower than those in the control group, while IFN-α was higher than that in the control group, and the differences were statistically significant (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】The clinical effect of pegylated interferon alpha-2a combined with tenofovir disoproxil fumarate in the treatment of HBeAg positive initial CHB is good. It inhibits the progression of liver fibrosis and inflammatory response, and has high safety.

Key words： Hepatitis B, Chronic Hepatitis B e Antigens Interferon alpha-2 Treatment Outcome

Received: 14 December 2024

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R512.62

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	TAN Fenglei
	ZHAO Min

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TAN Fenglei,ZHAO Min. Clinical Observation of Pegylated Interferon α-2a Combined with Tenofovir Disoproxil Fumarate in the Treatment of HBeAg-Positive Chronic Hepatitis B Patients[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(6): 1000-1003.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.06.025 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I6/1000

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