创伤性颅脑损伤患者血清S100β、NSE水平与颅脑损伤程度和预后的关系

doi:10.3969/j.issn.1671-7171.2025.06.032

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Abstract 【Objective】To investigate the relationship of serum levels of S100 calcium-binding protein β (S100β) and neuron-specific enolase (NSE) with the severity and prognosis in traumatic brain injury (TBI) patients.【Methods】A total of 116 TBI patients were categorized into three groups based on the Glasgow Coma Scale (GCS) score: mild group(n=53), moderate group(n=38), and severe group(n=25). They were also grouped by prognosis into the favorable prognosis (n=95) and the poor prognosis (n=21) groups. Serum levels of S100β and NSE were compared across these groups. Receiver operating characteristic (ROC) curves were constructed to assess the predictive value of serum S100β and NSE levels for patient prognosis.【Results】 Serum S100β and NSE levels in the mild group were significantly lower than those in the moderate group, while the levels of serum S100β and NSE in the moderate group were lower than those in the severe group (P<0.05). Patients in the poor prognosis group had significantly higher S100β and NSE levels than those in the favorable prognosis group (P<0.05). ROC analysis showed that the area under the curve (AUC) for the combined prediction using both S100β and NSE was significantly higher than that of either marker alone.【Conclusion】 Serum levels of S100β and NSE in TBI patients increase with the severity of the condition. They both have good predictive value for patient prognosis.

Key words： Craniocerebral Trauma S100 Proteins Phosphopyruvate Hydratase Prognosis

Received: 19 February 2025

PACS:

R651.15

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	Articles by authors
	LI Ke
	LI Bin
	HUANG Yongjie

Cite this article:

LI Ke,LI Bin,HUANG Yongjie. Relationship of Serum S100β and NSE Levels with the Severity and Prognosis in Traumatic Brain Injury Patients[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(6): 1027-1029.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.06.032 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I6/1027

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