Abstract：【Objective】To investigate the effect of single load with small dose esmolol on hemodynamic parameters of the elderly patients undergoing painless gastroscopy. 【Methods】A total of 160 elderly patients underwent painless gastroscopy were randomly divided into the observation group and the control group,with 80 cases in each group. The observation group was given a low dose of esmolol 0.3 mg/kg intravenously,while the control group was given a high dose of esmolol 0.5 mg/kg intravenously. The injection time of the two groups was administrated within 15 to 30 seconds. Hemodynamic parameters [heart rate (HR),systolic blood pressure (SBP),diastolic blood pressure (DBP) and oxygen saturation (SpO2)] before and after examination were compared between the two groups. After examination,the length of hospital observation,the duration of anesthesia wakefulness,the score of the Simple Mental State Assessment Scale (MMSE),the amount of anesthesia and the occurrence of adverse reactions between the two groups were compared as well. 【Results】After examination,HR,SBP and DBP levels of the two groups were lower than those before examination (P<0.05),however,HR,SBP and DBP of the observation group were higher than those of the control group (P<0.05). There was no statistical significance in SpO2 between the two groups before and after examination (P>0.05). There were no significant differences in hospital observation time,anesthetic waking time,MMSE score and anesthetic dosage between the two groups (P>0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group (P<0.05). 【Conclusion】Esmolol has a significant anesthetic effect in the elderly for painless gastroscopy,and small doses of esmolol are more conducive to stable blood circulation,and the adverse reactions are small,so it is recommended for clinical application.
李虎, 李海英. 单次负荷小剂量艾司洛尔对老年无痛胃镜检查时血流动力学参数的影响[J]. 医学临床研究, 2023, 40(8): 1190-1192.
LI Hu, LI Hai-ying. Effect of Single Load with Low Dose Esmolol on Hemodynamic Parameters in Elderly Patients Undergoing Painless Gastroscopy. JOURNAL OF CLINICAL RESEARCH, 2023, 40(8): 1190-1192.
[1] ZHANG H,CHEN J,CHEN C . Comparison of laparoscopy combined with gastroscopy positioning and open resection for gastric stromal tumours: A meta-analysis[J].J Minim Access Surg,2020,16(4):298-307. [2] 郭淼,王茂华,张建友,等. 瑞马唑仑复合瑞芬太尼用于无痛胃镜检查术的效果[J].中华麻醉学杂志,2021,41(5):576-579. [3] HAO L,HU X B,ZHU B Q,et al. Clinical observation of the combined use of propofol and etomidate in painless gastroscopy[J].Medicine,2020,99(45):e23061. [4] VINICIUS B,MORAIS R K,SAKATA A P,et al.Randomized,double-blind,placebo-controlled study of the analgesic effect of intraoperative esmolol for laparoscopic gastroplasty[J].Acta Cir Bras,2020,35(4):e202000408. [5] 徐恩国,刘文华,任诗佳,等. 艾司洛尔联合丹参多酚酸盐对老年冠心病心绞痛患者心功能、血流动力学及氧化应激指标的影响[J].中国老年学杂志,2020,40(2):228-231. [6] 张忠其,许亚菲,张艳静,等. 丙泊酚复合小剂量艾司氯胺酮抑制胃镜置入反应的有效剂量[J].临床麻醉学杂志,2021,37(9):949-952. [7] LIN Y,ZHANG X,LI L,et al. High-flow nasal cannula oxygen therapy and hypoxia during gastroscopy with propofol sedation: a randomized multicenter clinical trial[J].Gastrointest Endosc,2019,90(4):591-601. [8] 庞娜,赵蕊,范士民,等. 右美托咪啶复合异丙酚与艾司洛尔复合异丙酚对无抽搐电休克治疗患者血流动力学应激反应的影响[J].中国医师杂志,2021,23(11):1724-1727. [9] 杨礼,宫艺其,吴蕾,等. 艾司洛尔对人诱导多能干细胞来源心肌细胞自发动作电位的影响[J].中华麻醉学杂志,2020,40(10):1208-1212. [10] 常玉霞,韩旭,李悦,等. 艾司洛尔联合连续肾脏替代疗法治疗感染性休克临床研究[J].中华医院感染学杂志,2019,29(15):2299-2303. [11] 乐新会,黄晓霞,张磊,等. 艾司洛尔对腹腔镜胃癌根治术患者血流动力学和心肌损伤的影响[J].中华全科医学,2022,16(2):229-231. [12] LEVY B,FRITZ C,PIONA C,et al. Hemodynamic and anti-inflammatory effects of early esmolol use in hyperkinetic septic shock: a pilot study[J].Crit Care,2021,25(1):21. [13] MIRAGLIA D,MIGUUEL L A,ALONSO W . Esmolol in the management of pre-hospital refractory ventricular fibrillation: A systematic review and meta-analysis[J].Am J Emerg Med,2020,38(9):1921-1934.
2023, Vol. 40 
