重复经颅磁刺激联合氨磺必利治疗精神分裂症对患者认知功能及血清细胞因子水平的影响

doi:10.3969/j.issn.1671-7171.2023.08.019

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摘要【目的】探讨重复经颅磁刺激(rTMS)联合氨磺必利治疗精神分裂症对患者认知功能和血清细胞因子水平的影响。【方法】96例精神分裂症患者,随机分为两组,每组48例。对照组口服氨磺必利治疗,观察组在对照组基础上联合rTMS治疗。比较两组治疗前后威斯康星卡片分类测验(WCST)评分、阳性与阴性症状量表(PANSS)评分、血清学指标[白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]和不良反应发生情况。【结果】治疗后,两组完成分类数、总正确数评分高于治疗前,两组总应答数、持续错误数、总错误数评分低于治疗前(P<0.05),且观察组治疗后各项评分均优于对照组(P<0.05)。治疗后,两组阳性症状、阴性症状、一般精神病理评分及总分均低于治疗前(P<0.05),且观察组治疗后各项评分均低于对照组(P<0.05)。治疗后,两组血清IL-1β、IL-6、TNF-α水平较治疗前均有所降低(P<0.05),且观察组血清IL-6、TNF-α水平低于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】rTMS联合氨磺必利治疗精神分裂症患者有利于降低IL-6、TNF-α水平,减轻患者的症状,改善患者的认知功能,在临床上具有较好的应用价值。

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	李娟
	曹静

关键词 ：精神分裂症/治疗, 经颅磁刺激, 氨磺必利/治疗应用, 认知

Abstract：【Objective】This study aimed to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) combined with amisulpride treatment on cognitive function and serum cytokine levels in patients with schizophrenia. 【Methods】Ninety-six patients with schizophrenia were randomly divided into two groups,with 48 patients in each group. The control group received oral amisulpride treatment,while the observation group received rTMS in addition to amisulpride treatment. The Wisconsin Card Sorting Test (WCST) scores,Positive and Negative Syndrome Scale (PANSS) scores,serum markers [interleukin-1β (IL-1β),interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α)],and occurrence of adverse reactions were compared between the two groups before and after treatment. 【Results】After treatment,both groups showed higher scores in the number of categories completed and total correct responses and lower scores in the total number of responses,perseverative errors,and total errors compared to before treatment (P<0.05). Moreover,the observation group had significantly better scores in all these measures compared to the control group (P<0.05). After treatment,both groups had lower scores in positive symptoms,negative symptoms,general psychopathology,and total PANSS scores compared to before treatment (P<0.05); And the observation group showed significantly lower scores in all these measures compared to the control group (P<0.05). After treatment,both groups had decreased levels of serum IL-1β,IL-6,and TNF-α compared to before treatment (P<0.05),while the observation group had lower levels of serum IL-6 and TNF-α compared to the control group (P<0.05). There was no statistically significant difference in the overall incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】rTMS combined with amisulpride treatment in patients with schizophrenia is beneficial in suppressing IL-6 and TNF-α levels,reducing symptoms,and improving cognitive function. It has good clinical application value.

Key words： Schizophrenia/TH Transcranial Magnetic Stimulation Amisulpride/TU Cognition

收稿日期: 2022-10-29

中图分类号:

R749.3

通讯作者: ^*E-mail:caojing19870208@163.com

引用本文:

李娟, 曹静. 重复经颅磁刺激联合氨磺必利治疗精神分裂症对患者认知功能及血清细胞因子水平的影响[J]. 医学临床研究, 2023, 40(8): 1186-1189.
LI Juan, CAO Jing. Effects of Repetitive Transcranial Magnetic Stimulation Combined with Amisulpride Treatment on Cognitive Function and Blood Cytokine Levels in Patients with Schizophrenia. JOURNAL OF CLINICAL RESEARCH, 2023, 40(8): 1186-1189.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2023.08.019 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2023/V40/I8/1186

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