Abstract：【Objective】To investigate the effects of different doses of silicone oil and streptomycin on the visual field clarity and anesthetic dosage in electronic gastroscopy. 【Methods】A total of 231 patients who underwent electronic gastroscopy in our hospital from August 2020 to August 2021 were prospectively selected. They were randomly divided into low dose group (200 mg of silicone oil),medium dose group (400 mg of silicone oil) and high dose group (600 mg of silicone oil),with 77 patients in each group. The patients in the three groups were compared in terms of gastroscope visual field clarity,excellent and good rate,anesthetic dosage,total time of gastroscope examination and adverse reaction rate during gastroscope examination (decreased blood oxygen saturation,slow heart rate,choking,vomiting,dizziness). The hemodynamic indexes [heart rate (HR),mean arterial pressure (MAP)] of the three groups of patients before administration (T0),immediately after induction administration (T1),at the time of endoscopy (T2),at the beginning of examination (T3) and at the end of the examination (T4)were measured. 【Results】There were significant differences in the excellent and good rate of visual field definition among the three groups:the high-dose group>medium-dose group>low-dose group; And the differences were statistically significant (P<0.05). The anesthesia dosage and total time of gastroscopy in the three groups were high-dose group<medium-dose group<low-dose group. The differences were significantly different (P<0.05). There was no significant difference in HR and MAP between the three groups at different time points (P>0.05). The incidence of adverse reactions among the three groups was statistically significant as the middle-dose group<low-dose group<high-dose group. 【Conclusion】Streptomyces protease (pronase) combined with 400 mg of silicone oil is more suitable for use in electronic gastroscopy,which can not only improve the visual field of electronic gastroscopy,but also reduce the adverse reactions of patients,which is worthy of clinical reference.
吴小配, 于智慧, 房晓文. 链霉蛋白酶联合不同剂量西甲硅油对电子胃镜检查中视野清晰度及麻醉药用量的影响[J]. 医学临床研究, 2023, 40(2): 245-247.
WU Xiao-pei, YU ZHi-hui, FANG Xiao-wen. Effects of Streptomycin Combined with Different Doses of Simethicone Oil on Visual Field Clarity and Anesthetic Dosage in Electronic Gastroscopy. JOURNAL OF CLINICAL RESEARCH, 2023, 40(2): 245-247.
[1] 李万瑀,许延林,徐明,等. 盐酸达克罗宁与西甲硅油联合糜蛋白酶在无痛胃镜检查患者中的应用效果[J].解放军预防医学杂志,2019,37(8):53-54.
[2] 张秀莲. 链霉蛋白酶颗粒对无痛胃镜检查患者视野清晰度及疾病检出率影响分析[J].解放军预防医学杂志,2019,37(4):158-159.
[3] SEY M ,YAN B ,MCDNOALD C ,et al. A randomized controlled trial of high volume simethicone to improve visualization during capsule endoscopy[J].PLoS One,2021,16(4):455-457.
[4] LIU J T,WU J,WANG H R,et al. Spraying rhubarb powder solution under gastroscope in the treatment of acute non-varicose upper gastrointestinal bleeding:A systematic review and meta-analysis of randomized controlled trials–science direct[J].Complement Ther Med,2020,52(7):638-641.
[5] CONATY E A ,NOVAK S ,AVITIA R ,et al. Endoscopic gastrojejunal revision (transoral outlet reduction) for persistent hypoglycemia after gastric bypass[J].Obes Surg,2019,55(7):14-19.
[6] ANDERSON M J,SIPPEY M ,MARKS J . Gastric per oral pyloromyotomy for post-vagotomy-induced gastroparesis following esophagectomy[J].J Gastrointest Surg,2019,24(3):745-746.
[7] 陈光毅,李秀梅,陈进忠,等. 胃黏膜清洁剂联合体位操对胃镜检查效果的影响[J].护理学杂志,2021,36(20):40-41.
[8] 陈媛,滕卫军,陈燕萍,等. 链霉蛋白酶联合医用胃镜胶在无痛胃镜检查前胃腔准备中的应用效果观察[J].浙江医学,2019,41(11):1173-1175.
[9] 黄平,张皞,张筱凤,等. 链霉蛋白酶+西甲硅油对无痛胃镜检查效果的影响[J].中国内镜杂志,2021,27(11):17-24.
[10] 刘之枫,谈涛,顿珊珊,等. 链霉蛋白酶+西甲硅油+碳酸氢钠溶液配制后放置不同时间口服对胃镜检查质量的影响[J].中国内镜杂志,2020,26(5):26-31.
[11] PATEL T A ,PATEL M ,RAJAGOPALAN K,et al. Safety and efficacy of almagate and simethicone combination in symptomatic management of gerd:post-marketing observational TRIALMA Study[J].J Clin Diagnost Res,2020,14(3):883-889.
[12] 王洋,黎晓琴,史思文,等. 聚乙二醇联合西甲硅油对结肠镜检查患者Boston肠道准备量表评分及耐受度的影响[J].中国综合临床,2021,37(5):411-415.
2023, Vol. 40 
