Abstract：【Objective】To analyze the clinicopathological characteristics and prognosis of gastric Neuroendocrine tumor (G-NEN). 【Methods】A total of 64 cases of G-NEN in Yancheng Third People's Hospital from June 2016 to January 2022 were retrospectively analyzed. According to the fifth edition of the WHO digestive system tumor classification standard in 2019, their pathological classification and grading were carried out. Their clinical data, pathological characteristics, immunophenotype, treatment and prognosis were analyzed. 【Results】Sixty-four G-NEN patients had more males than females, with an average age of (65.7±9.01) years. Most patients presented with abdominal pain. Low grade G-NEN was mainly located in the gastric body, while high grade NEN and MiNEN were more common in the cardia. There were statistically significant differences in age, maximum tumor diameter, tumor location, number of tumors, morphology under gastroscopy, lymph node metastasis, and TNM staging among patients with different pathological types (P<0.05). The expression of Syn in immunohistochemistry was significantly higher than that of CgA, and the difference was statistically significant (P<0.05). Following up for 5-60 months, the prognosis of low-grade NEN was better than that of patients in the high-level NEN and MiNEN groups (P<0.05). There was no statistically significant difference in the prognosis between NET G3 and NEC, NEC and MiNEN (P>0.05). 【Conclusion】G-NEN is more common in elderly men, mainly manifested as abdominal pain. Different pathological types of G-NEN have different clinical and pathological characteristics and biological behaviors. High grade NEN and MiNEN have poor prognosis.
蒋蕾, 邱静, 梁晓东, 王婷婷. 64例胃神经内分泌肿瘤的分类、分级与临床特征及预后关系[J]. 医学临床研究, 2023, 40(7): 991-994.
JIANG Lei, Qiu Jing, LIANG Xiao-dong, et al. Study on the Relationship between Classification and Clinical Characteristics of 64 Cases of Gastric Neuroendocrine Tumor. JOURNAL OF CLINICAL RESEARCH, 2023, 40(7): 991-994.
[1] CIVES M,STROSBERG J R. Gastroenteropancreatic neuroendocrine tumors[J].CA Cancer J Clin,2018,68(6):471-487. [2] 刘彤华. 诊断病理学[M]. 3版. 北京:人民卫生出版社,2013:55. [3] NAGTEGAAL I D, ODZE R D, KLIMSTRA D, et al. The 2019 WHO classification of tumours of the digestive system[J].Histopathology,2020, 76(2):182-188. [4] FAN J H, ZHANG Y Q, SHI S S, et al. A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in china[J].Oncotarget,2017, 8(42):71699-71708. [5] 王钰虹,林原,薛玲,等. 87例胃肠胰神经内分泌肿瘤的诊治 分析[J].中华消化杂志2011, 31(8):531-535. [6] YAO J C, HASSAN M, PHAN A, et al. One hundred years after 'carcinoid':epidemiology of and prognostic factors for neuroendoceine rumors in 35,825 cases in the United States[J].J Clin Oncol,2008,26(18):3063-3072. [7] 郭林杰,唐承薇. 我国胃肠胰神经内分泌肿瘤临床现状分析[J].中国实用外科杂志, 2014, 34(6):490-492. [8] ÖBERG K,KNIGGE U,KWEKKEBOOM D,et al. Neuroendocrine gastro-entero-pancreatic tumors:ESMO Clinical Practice Guidelines for diagnosis,treatment and follow-up[J].Ann Oncol,2012,23(Suppl 7) :124-130. [9] 熊羽佳,程翠娥,李锐,等. 胃神经内分泌肿瘤148例临床病理特征和预后分析[J].中华消化杂志,2020,40(6):407-410. [10] LAZARTE R,PONIACHIK J,SMOK G,et al. Gastric neuroendocrine tumors:clinical,endoscopic presentation and alternatives of treatment[J].Rev Med Chil,2002,130(9):985-992. [11] 张鹏,李承果,贾杰. 胃神经内分泌肿瘤96例临床病理特征及预后分析[J].中国实用外科杂志,2020,40(7):824-829. [12] 钱小星,杨仁保,周杭城. 嗜铬素A、突触素联合神经内分泌激素检测对胃肠胰神经内分泌肿瘤诊断及预后临床价值[J].肝胆外科杂志,2015,23(2):148-151. [13] GORETZKI P E, STARKE A,AKCA A, et al. Surgery for neuroendocrine tumors of the gastroenteropancreatic system (GEP NET)[J].Internist (Berl),2012,53(2):152-160.
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