MPV/PC、NF-κB、Fibulin-3与主动脉夹层患者预后的关系

doi:10.3969/j.issn.1671-7171.2023.07.019

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摘要【目的】探讨不同预后的主动脉夹层患者血清平均血小板体积(MPV)/血小板计数(PC)、核因子-κB(NF-κB)、纤维蛋白3(Fibulin-3)水平。【方法】选取2020年3月至2022年2月本院收治的92例主动脉夹层患者,根据患者生存情况将其分为预后良好组(存活,n=65)、预后不良组(病死,n=27)。分析两组入院时、术后7 d血清MPV/PC、NF-κB、Fibulin-3水平,分析入院时各血清指标与主动脉夹层风险评分、心功能指标[血清肌钙蛋白I(cTnI)、左心室舒张末期内径(LVEDD)、左室射血分数(LVEF)]的相关性。偏回归分析主动脉夹层患者预后不良的危险因素,分析术后7 d血清指标对主动脉夹层患者预后不良的预测价值。【结果】术后7 d,预后不良组MPV/PC、NF-κB水平高于预后良好组,Fibulin-3水平低于预后良好组(P<0.05);MPV/PC、NF-κB、Fibulin-3与cTnI、LVEDD、风险评分、LVEF、预后不良密切相关(P<0.05)。联合预测主动脉夹层患者预后不良的AUC大于单项预测(P<0.05)。【结论】预后不良的主动脉夹层患者中MPV/PC、NF-κB水平升高,Fibulin-3水平降低,三者联合检测对患者预后不良具有较高的预测价值。

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	李静
	祖晓堋
	白瑞莉

关键词 ：主动脉疾病, 平均血小板体积, NF-κB, 纤维蛋白, 预后

Abstract：【Objective】To investigate the levels of serum mean platelet volume (MPV)/platelet count (PC), nuclear factor-κB (NF-κB), and Fibrinolin-3 in patients with aortic dissection (AD) with different prognosis.【Methods】A total of 92 patients with Aortic dissection admitted to our hospital from March 2020 to February 2022 were selected, and they were divided into two groups according to their survival conditions:good prognosis group (survival, n=65) and poor prognosis group (death, n=27). We analyzed the levels of serum MPV/PC, NF-κB, and Fibulin-3 at admission and 7 days after surgery in the two groups, and analyzed the correlation between the serum indicators at admission and the risk score of Aortic dissection, cardiac function indicators [serum Troponin I (cTnI), left ventricular end diastolic diameter (LVEDD), left ventricular Ejection fraction (LVEF)]. The risk factors of poor prognosis in patients with Aortic dissection were analyzed by partial regression. The prognostic value of serum parameters 7 days after operation in patients with Aortic dissection was analyzed.【Results】7 days after surgery, the levels of MPV/PC and NF-κB in the poor prognosis group were higher than those in the good prognosis group, while the levels of Fibulin-3 were lower than those in the good prognosis group (P<0.05); MPV/PC, NF-κB, Fibulin-3 were closely related to cTnI, LVEDD, risk score, LVEF, and poor prognosis (P<0.05). The AUC of combined prediction of poor prognosis in patients with Aortic dissection was greater than that of single prediction (P<0.05).【Conclusion】 In patients with poor prognosis of aortic dissection, the levels of MPV/PC and NF-κB are increased, and the levels of Fibulin-3 are decreased. The joint prediction of poor prognosis of patients has high predictive value.

Key words： Aortic Diseases Mean Platelet Volume NF-kappa B Fibrin Prognosis

收稿日期: 2022-12-09

中图分类号:

R543.16

引用本文:

李静, 祖晓堋, 白瑞莉. MPV/PC、NF-κB、Fibulin-3与主动脉夹层患者预后的关系[J]. 医学临床研究, 2023, 40(7): 1029-1031.
LI Jing, ZU Xiao-peng, BAI Rui-li. The Relationship between MPV/PC, NF-κB, Fibulin-3 and the Prognosis of Patients with Aortic Dissection. JOURNAL OF CLINICAL RESEARCH, 2023, 40(7): 1029-1031.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2023.07.019 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2023/V40/I7/1029

[1] 黄英,陈兰,周英艳,等.急性主动脉夹层患者血浆miR-30a及D-二聚体水平检测对临床预后判断价值[J].现代检验医学杂志,2022,37(3):187-190.
[2] 魏海燕,史宏伟,李滢,等.急性A型主动脉夹层患者围术期低氧血症发生率、血小板活化标志物、血清炎症指标水平变化及其意义[J].山东医药,2019,59(24):56-59.
[3] 张霍,吕向妮,付文,等.带膜血管内支架对Stanford B型胸主动脉夹层病人血清IFN-γ、IL-1β、NF-κB、VEGF水平、心肺功能、远期预后的影响[J].中西医结合心脑血管病杂志,2022,20(11):2017-2021.
[4] 林忠伟,王卓,张炽明,等.高血压合并降主动脉夹层患者血清Fibulin-3和肱-踝脉搏波传导速度的相关性研究[J].临床心血管病杂志,2019,35(5):444-447.
[5] 景在平.主动脉夹层的诊断和腔内隔绝术应用指南(初稿)[J].中国实用外科杂志,2004,24(3):129-133.
[6] 孟少志,刘奇娟.急性主动脉夹层患者血清中D-二聚体、MMP-9水平变化及临床意义[J].中国医药导报,2018,15(25):144-147.
[7] 王萍,郑雪梅.舒适护理对主动脉夹层患者术后应激反应及预后的影响[J].医学临床研究,2019,36(6):1248-1249.
[8] 徐朝军,宋岚,刘丹薇,等.血必净注射液对Stanford B型主动脉夹层患者腔内修复术后炎症细胞因子的影响[J].中国中西医结合急救杂志,2017,24(4):389-392.
[9] 高红霞,杨彩霞,任刚.外周血单个核细胞miR-150表达对STEMI患者PCI术后发生左心室重构的预测价值[J].东南大学学报(医学版),2021,40(2):170-175.
[10] 李建涛,杨旭光,郭树领.血清YKL-40、IL-33及MPV/PC与冠心病PCI术患者预后的相关分析[J].分子诊断与治疗杂志,2022,14(7):1133-1136.
[11] 陈慧玲,郭晓艳,任月霞,等.呼吸道感染并发心肌炎患者血清MCP-1与NF-κB及CypA/CD147的表达[J].中华医院感染学杂志,2020,30(14):2154-2158.
[12] SHARMA P,BECK D,MURTHA L A, et al. Fibulin-3 deficiency protects against myocardial injury following ischaemia/reperfusion in in vitro cardiac spheroids[J].Front Cardiovasc Med,2022,9(1):913156-913166.