Abstract：【Objective】To investigate the effect of dexmedetomidine on short-term prognosis and Th1/Th2 balance in patients undergoing thoracoscopic pulmonary nodules. 【Methods】A total of 88 patients with pulmonary nodules admitted to our hospital were divided into the observationy group and the control group,with 44 cases in each group. Patients in two groups underwent thoracoscopic pulmonary nodule surgery with general anesthesia. In the observation group,dexmedetomidine 0.5 μg/kg was injected intravenously 15 minutes before induction of anesthesia and continuously pumped at 0.2-0.4 μg/(kg?h) intraoperative dexmedetomidine during the operation. The control group received normal saline instead of dexmedetomidine. After surgery,both groups used intravenous patient-controlled analgesia pump:sufentanyl 0.05 μg/(kg?h)+dexmedetomidine 3.5 μg/kg in the observation group and sufentanyl 0.05 μg/(kg?h) in the control group. These drugs were diluted in 100 mL of normal saline. The hemodynamic cardiac output (CO),mean arterial pressure (MAP) changes,Th1/Th2 cytokine,interleukin-2 (IL-2),interleukin-4 (IL-4) levels,quality of recovery,postoperative complications,and safety before and after surgery were compared in the two groups. 【Results】The levels of both CO and MAP at 2 h during the operation were lower than before anesthesia in the two groups (P<0.05). And levels of CO and MAP in the observation group were lower than those in the control group (P<0.05). There were no significant differences in IL-2 and IL-4 levels between the two groups before anesthesia (P> 0.05),however,at 3 h after the surgery, the peripheral blood IL-2 level was higher than those before surgery in both groups (P<0.05). And the IL-2 level in the observation group was significantly higher than that in the control group (P<0.05). Compared to pre-anesthesia,levels of IL-4 at 3 h after surgery in both groups were lower (P<0.05); And IL-4 level in the observation group was significantly lower than that in the control group (P<0.05). There was no significant difference in operation time and recovery time between the two groups (P>0.05). The incidence of complications and adverse reactions in the observation group were lower than those in the control group (P<0.05).【Conclusion】Dexmedetomidine in patients undergoing thoracoscopic pulmonary nodules surgery can improve the Th1/Th2 immune balance and improve the short-term outcome.
2023, Vol. 40 
