Effects of Laparoscopic Radical Resection of Right Colon Cancer via a Cephalic Central Mixed Approach on Serum levels of P1k-1,TSGF and its Prognosis in Patients with Colorectal Cancer
Abstract：【Objective】 To investigate the effect of laparoscopic radical resection of right colon cancer through a cephalic central mixed approach on the serum levels of Polo like kinase 1 (P1k-1),tumor specific growth factor (TSGF),and prognosis in patients with right colon cancer. 【Methods】 The clinical data of 136 patients with right colon cancer admitted to Qishan County Hospital from January 2018 to January 2021 were retrospectively analyzed. According to the different surgical approaches,they were divided into the observation group (laparoscopic right colon cancer radical surgery via cephalic central mixed approach) and the control group (laparoscopic right colon cancer radical surgery via central approach),with 68 patients in each group. The operation time,intraoperative bleeding,total number of lymph node dissection,postoperative anal exhaust time,postoperative feeding start time,postoperative hospitalization time,and the incidence of intraoperative blood transfusion,vascular injury,and conversion to laparotomy were compared between the two groups. The incidence of complications and the levels of serum P1k-1 and TSGF before and 7 days after surgery were compared between the two groups. 【Results】 The operative time,intraoperative bleeding,and incidence of intraoperative blood transfusion in the observation group were significantly lower than those in the control group (P<0.05). The complication rate in the observation group was 17.65%,while the complication rate in the control group was 30.88%. There was no statistically significant difference between the two groups (P=0.072). Seven days after surgery,the serum levels of P1k-1 and TSGF in the two groups were lower than those before surgery (P<0.05),but there was no statistically significant difference between the two groups (P>0.05). During a one-year follow-up,there was no statistically significant difference in the local recurrence rate and distant metastasis rate between the two groups (P>0.05). The one-year cumulative survival rate in the observation group was 92.65% (63/68),while the one-year cumulative survival rate in the control group was 89.71% (61/68). There was no statistically significant difference between the two groups (P=0.507). 【Conclusion】 Compared with the central approach,laparoscopic radical resection of right colon cancer through the cephalic central mixed approach can also thoroughly clean lymph nodes,reduce intraoperative bleeding,and shorten surgical time. It has no significant impact on short-term and long-term efficacy,postoperative complications,and serum P1k-1,TSGF levels.
王晓岐, 万莹. 头侧-中央混合入路方式行腹腔镜下右半结肠癌根治术对患者血清P1k-1、TSGF水平及预后的影响[J]. 医学临床研究, 2023, 40(3): 396-399.
WANG Xiao-qi, WAN Ying. Effects of Laparoscopic Radical Resection of Right Colon Cancer via a Cephalic Central Mixed Approach on Serum levels of P1k-1,TSGF and its Prognosis in Patients with Colorectal Cancer. JOURNAL OF CLINICAL RESEARCH, 2023, 40(3): 396-399.
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2023, Vol. 40 
