Abstract：【Objective】To investigate the relationship of the severity and prognosis of acute pulmonary embolism (APE) with levels of Copeptin, D-dimer, and blood sodium. 【Methods】A total of 84 patients diagnosed with acute pulmonary embolism in our hospital were selected as the observation group, and 84 healthy individuals undergoing physical examination during the same period were selected as the control group. The levels of Copeptin, D-dimer (D-D), and blood sodium were compared between the two groups. According to the Pulmonary Embolism Severity Index (PESI), the levels of Copeptin, D-D, and blood sodium in patients with different severity grades were compared in the observation group. The prognosis of the observation group was analyzed, and the levels of Copeptin, D-D, and blood sodium were compared among patients with different prognosis. The relationship of Copeptin, D-D and blood sodium levels with the severity and prognosis of acute pulmonary embolism was analyzed. 【Results】The levels of Copeptin and D-D in the observation group were significantly higher than those in the control group (P<0.05), while the blood sodium level was lower than that in the control group (P<0.05). According to the PESI grading, there were 22 cases of grade Ⅰ, 30 cases of grade Ⅱ, 20 cases of grade Ⅲ, 12 cases of grade Ⅳ, and no cases of grade Ⅴ in the 84 patients in the observation group. With the increase in PESI grade, the levels of Copeptin and D-D gradually increased, while the blood sodium level gradually decreased. The differences between groups were statistically significant (P<0.05). Among the 84 patients in the observation group, 9 patients (10.71%) died in the death group and 75 patients (89.29%) survived in the survival group. The levels of Copeptin and D-D in the death group were higher than those in the survival group (P<0.05), while the blood sodium level was lower than that in the survival group (P<0.05). Spearman's correlation analysis showed that Copeptin and D-D levels in patients with acute pulmonary embolism were positively correlated with the severity and prognosis (P<0.05), while blood sodium levels were negatively correlated with the severity and prognosis (P<0.05). 【Conclusion】Levels of Copeptin and D-D are significantly elevated, while blood sodium level is significantly reduced in patients with acute pulmonary embolism. Those levels are correlated with the severity and prognosis of the disease.
惠文静, 许海英, 王赖儿. 和肽素、D-二聚体及血钠水平与急性肺栓塞患者病情严重程度及预后的关系[J]. 医学临床研究, 2023, 40(7): 1063-1065.
HUI Wen-jing, XU Hai-ying, WANG Lai-er. Relationship of Severity and Prognosis of Acute Pulmonary Embolism with Levels of Copeptin, D-dimer, and Blood Sodium. JOURNAL OF CLINICAL RESEARCH, 2023, 40(7): 1063-1065.
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2023, Vol. 40 
