HBsAg/HBV DNA值与乙型肝炎患者TGF-β1、Tim-3水平的关系

doi:10.3969/j.issn.1671-7171.2023.02.021

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摘要【目的】探讨乙型肝炎患者乙型肝炎表面抗原(HBsAg)/乙型肝炎病毒(HBV) DNA值与转化生长因子-β1(TGF-β1)、T淋巴细胞免疫球蛋白黏蛋白分子3(Tim-3)水平的关系。【方法】两院收治的70例乙型肝炎患者,依据病情严重程度将患者分为轻度HBV组(22例)、中度HBV组(30例)、重度HBV组(18例),另选同期体检的健康志愿者30例为对照组。收集所有研究对象的临床血生化资料,比较各组肝功能指标及HBsAg/HBV DNA、TGF-β1、Tim-3水平,采用Pearson相关分析HBsAg/HBV DNA值与乙型肝炎患者TGF-β1、Tim-3水平的关系。【结果】不同病情严重程度的HBV患者及对照组间血清谷丙转氨酸(ALT)、谷草转氨酸(AST)、总胆红素(TBIL)、血小板计数(PLT)水平比较,均为对照组＜轻度HBV组＜中度HBV组＜重度HBV组,且各组比较差异均有统计学意义(均P＜0.05)。各组HBsAg/HBV DNA值比较,轻度HBV组＞中度HBV组＞重度HBV组(均P＜0.05);各组TGF-β1、Tim-3水平比较,对照组＜轻度HBV组＜中度HBV组＜重度HBV组(均P＜0.05)。HBsAg/HBV DNA比值与乙型肝炎患者TGF-β1、Tim-3水平呈显著负相关(P<0.05)。【结论】乙型肝炎患者HBsAg/HBV DNA值与TGF-β1、Tim-3水平呈显著负相关。

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	姚博方
	高芳芳

关键词 ：乙型肝炎, 乙型肝炎表面抗原, DNA, 病毒, 转化生长因子β1

Abstract：【Objective】To investigate the relationship of ratio of hepatitis B surface antigen (HBsAg)/hepatitis B virus (HBV) DNA with transforming growth factor-β1(TGF-β1) and T lymphocyte immunoglobulin mucin 3 (Tim-3) levels in patients with hepatitis B.【Methods】Seventy patients with hepatitis B admitted to our hospitals were divided into the mild HBV group (22 cases),the moderate HBV group (30 cases) and the severe HBV group (18 cases) according to the severity of the disease.Another 30 healthy people who were examined at the same time were selected as the control group.The clinical blood biochemical data of all subjects,liver function indexes,TGF-β1,Tim-3 level and the ratio of HBsAg/HBV DNA were analyzed by Pearson correlation.【Results】The levels of serum alanine aminotransferase (ALT),aspartate aminotransferase (AST),total bilirubin (TBIL) and platelet count (PLT) in patients with HBV of different severity and the control groups were in order of the control group<the mild HBV group the moderate HBV group the severe HBV group.The differences among the groups were significant (P<0.05).The comparison of HBsAg/HBV DNA ratios in each group showed the order of the mild HBV group>the moderate HBV group>the severe HBV group (P<0.05).The levels of TGF -β1 and Tim-3 in the control group were lower than those in all HBV groups (the mild HBV group the moderate HBV group the severe HBV group) (all P<0.05).HBsAg/HBV DNA ratio-was significantly negatively correlated to levels of TGF-β1 and Tim-3 in Patients with Hepatitis B (P<0.05).【Conclusion】The ratio of HBsAg/HBV DNA is negatively related to levels of both TGF-β1 and Tim-3 in patients with hepatitis B.

Key words： Hepatitis B Hepatitis B Surface Antigens DNA, Viral Transforming Growth Factor beta1

收稿日期: 2022-04-19

中图分类号:

R512.62

通讯作者: *E-mail:308274360@qq.com

引用本文:

姚博方, 高芳芳. HBsAg/HBV DNA值与乙型肝炎患者TGF-β1、Tim-3水平的关系[J]. 医学临床研究, 2023, 40(2): 234-236.
YAO Bo-fang, GAO Fang-fang. Relationship of HBsAg/HBV DNA Ratio with TGF-β1 and Tim-3 Levels in Patients with Hepatitis B. JOURNAL OF CLINICAL RESEARCH, 2023, 40(2): 234-236.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2023.02.021 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2023/V40/I2/234

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