摘要【目的】探讨急性髓系白血病(AML)Fms样酪氨酸激酶3-内部串联重复(FLT3-ITD)基因阳性患者白血病相关免疫表型(LAIP)及临床特征。【方法】选取2016年3月至2020年3月本院收治的206例急性髓系白血病患者作为研究对象,根据FLT3-ITD基因有无突变情况将其分为观察组(43例)与对照组(163例)。回顾性分析两组患者临床资料及LAIP,并比较两组患者生存情况及1个疗程化疗结局,进而评价FLT3-ITD阳性在AML患者中的价值。【结果】观察组患者CD56、CD11b、CD7及CD33表达较对照组增高,而CD34、CD117表达较对照组减低(P<0.05);观察组无病生存率及总生存率均较对照组低(P<0.05);观察组患者缓解率较对照组减低(41.86% vs 80.37%,P<0.05);完全缓解患者细胞抗原表达率较未缓解患者减低(P<0.05)。【结论】FLT3-ITD基因阳性AML患者白血病细胞表面抗原分化紊乱,缓解率低,预后不良。AML患者FLT3-ITD基因及LAIP表达情况对临床指导治疗、判断预后有重要意义。
Abstract：【Objective】To investigate the leukemia-associated immunophenotype (LAIP) and clinical features in acute myeloid leukemia (AML) with positive Fms-like tyrosine kinase 3-internal tandem repeat (FLT3-ITD) expression. 【Methods】A total of 206 patients with acute myeloid leukemia admitted to our hospital from March 2016 to March 2020 were selected as the study subjects. Patients were divided into the FLT3-ITD positive expression group (43 cases) and the FLT3-ITD negative expression control group (163 cases) according to the mutation status of FLT3-ITD gene. Clinical data and LAIP of the two groups were retrospectively analyzed. The survival of two groups and the outcome of one course of chemotherapy were compared between the two groups to evaluate the value of FLT3-ITD positive expression in AML patients. 【Results】The patients in the FLT3-ITD positive group had higher CD56, CD11b, CD7 and CD33 expressions than those in the FLT3-ITD negative control group, while their CD34 and CD117 expression levels were lower than those in the control group (P<0.05). The disease-free survival rate and overall survival rate of the positive group were lower than those of the control group (P<0.05). The remission rate of the positive patients was lower than that of the control group (41.86% vs 80.37%, P<0.05). The cell antigen expression rate of the patients in the complete remission group was lower than that in the non-remission group (P<0.05). 【Conclusion】FLT3-ITD gene positive AML patients have antigen differentiation disorder on the surface of leukemia cells, low remission rate and poor prognosis. The expression of FLT3-ITD gene and LAIP in AML patients are of great significance for clinical guidance of treatment and prognosis judgment.
周英, 刘婷, 严湘红. 急性髓系白血病FLT3-ITD阳性患者LAIP及临床特征分析[J]. 医学临床研究, 2022, 39(2): 252-254.
ZHOU Ying, LIU Ting, YAN Xiang-hong. Analysis of Leukemia-associated Immunophenotype and Clinical Features in AML patients with FLT3-ITD Positive Expression. JOURNAL OF CLINICAL RESEARCH, 2022, 39(2): 252-254.
2022, Vol. 39 
