子宫内膜中CD138表达对慢性子宫内膜炎合并RIF患者妊娠结局的预测价值

doi:10.3969/j.issn.1671-7171.2023.02.020

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摘要【目的】探讨子宫内膜中膜硫酸乙酰肝素蛋白多糖配体蛋白聚糖-1(CD138)表达对慢性子宫内膜炎(CE)合并反复着床失败(RIF)患者妊娠结局的预测价值。【方法】选取2019年8月至2020年10月榆林市第二医院收治的126例CE合并RIF患者,统计所有患者临床妊娠情况,依据是否妊娠成功分为成功组(n=59)和失败组(n=67)。比较两组患者临床资料,Logistic多因素回归分析CE合并RIF患者妊娠结局的危险因素;制作受试者工作特征(ROC)曲线,以曲线下面积(AUC)分析子宫内膜中CD138表达对CE合并RIF患者妊娠结局的预测效能。【结果】126例CE合并RIF患者临床妊娠失败率为53.17%(67/126)。CD138阳性表达患者临床妊娠率、持续妊娠率及分娩率均低于CD138阴性表达(P<0.05)。失败组年龄、黄体生成素(LH)、卵泡生成素(FSH)、窦卵泡数、移植胚胎数、囊胚率低于成功组(P<0.05),CD138阳性占比、CD138的组织化学评分(H-SCORE)则高于成功组(P<0.05)。Logistic多因素分析结果显示:移植胚胎数、CD138表达阳性、CD138的H-SCORE均是影响CE合并RIF患者妊娠结局的独立因素(OR=2.807、3.089、3.367,P<0.05)。ROC曲线分析显示:子宫内膜中CD138的H-SCORE预测CE合并RIF患者妊娠结局的最佳截断点为107.43分,AUC为0.826。【结论】子宫内膜中CD138的 H-SCORE对CE合并RIF患者妊娠结局的预测价值较高,可作为预测该类患者妊娠结局的重要参考指标。

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	朱静
	李海香
	江赛

关键词 ：多配体蛋白聚糖1, 子宫内膜炎, 胚胎植入, 妊娠结局

Abstract：【Objective】To investigate the predictive value of membrane heparan sulfate proteoglycan ligand-1 (CD138) expression in the endometrium for pregnancy outcome in patients with chronic endometritis (CE) complicated with recurrent implantation failure (RIF). 【Methods】 A total of 126 patients with CE combined with RIF admitted to our hospital from August 2019 to October 2020 were selected as the research objects. Statistics of clinical pregnancy of all subjects were conducted. According to the clinical success of pregnancy,they were divided into success group (59 cases) and failure group (67 cases). The clinical data of patients in the failure and success groups were compared. Logistic multivariate regression analysis of risk factors affecting pregnancy outcomes in CE complicated with RIF patients was performed. Receiver operating characteristic (ROC) curve was prepared,and the area under the curve (AUC) was used to analyze the predictive power of CD138 expression in the endometrium on pregnancy outcomes in patients with CE complicated with RIF. 【Results】The clinical pregnancy failure rate of 126 CE patients with RIF was 53.17%(67/126). The clinical pregnancy rate,continuous pregnancy rate and delivery rate of CD138 positive expression were lower than those of negative expression (P<0.05). The age,luteinizing hormone (LH),follicle-generating hormone (FSH),number of antral follicles,number of transferred embryos,and blastocyst rate in the failure group were lower than those in the successful group (P<0.05),while the proportion of CD138 positive and Histochemical score (H-SCORE) were higher in the successful group (P<0.05). Logistic multivariate analysis showed that the number of embryos transferred,CD138 positive expression,and H-SCORE were independent factors affecting the pregnancy outcome of patients with CE complicated with RIF (OR=2.807,3.089,3.367,P<0.05). The ROC analysis showed that the best cut-off point of the CD138 H-SCORE score in the endometrium for predicting the pregnancy outcome of patients with CE complicated with RIF was 107.43 points,and the AUC was 0.826.【Conclusion】The H-SCORE of CD138 in the endometrium has a high predictive value for the pregnancy outcome of patients with CE complicated with RIF,and can be used as an important reference index to predict the clinical outcome of such patients.

Key words： Syndecan-1 Endometritis Embryo Implantation Pregnancy Outcome

收稿日期: 2022-04-24

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通讯作者: *E-mail:491141487@qq.com

引用本文:

朱静, 李海香, 江赛. 子宫内膜中CD138表达对慢性子宫内膜炎合并RIF患者妊娠结局的预测价值[J]. 医学临床研究, 2023, 40(2): 230-233.
ZHU Jing, LI Hai-xiang, JIANG Sai. Predictive Value of the Expression of CD138 in the Endometrium on the Pregnancy Outcome of Patients with Chronic Endometritis and RIF. JOURNAL OF CLINICAL RESEARCH, 2023, 40(2): 230-233.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2023.02.020 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2023/V40/I2/230

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