扶正化瘀胶囊与双歧杆菌三联活菌辅助替诺福韦对老年乙肝肝硬化患者肝纤维化程度的影响

doi:10.3969/j.issn.1671-7171.2023.01.032

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摘要 【目的】 探讨扶正化瘀胶囊与双歧杆菌三联活菌辅助替诺福韦对老年乙肝肝硬化(HBC)患者肝纤维化程度的影响。【方法】 回顾性分析2019年4月至2021年4月安康市中心医院收治的93例老年HBC患者的临床资料,根据治疗方法的不同将其分为扶正化瘀组、活菌组和联合组,每组31例。三组均给予替诺福韦治疗,扶正化瘀组予以扶正化瘀胶囊,活菌组予以双歧杆菌三联活菌,联合组予以扶正化瘀胶囊、双歧杆菌三联活菌联合治疗。比较三组乙肝病毒DNA定量(HBV-DNA)、HBV-DNA转阴率、肝功能指标[丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)、天冬氨酸氨基转移酶(AST)]、肝纤维化指标[Ⅲ型前胶原(PC-Ⅲ)、透明质酸(HA)、层粘连蛋白(LN)、Ⅳ型胶原(Ⅳ-C)]及血清炎性因子[肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、IL-8]。【结果】 治疗后,三组HBV-DNA水平较治疗前降低,联合组低于活菌组、扶正化瘀组,扶正化瘀组低于活菌组,差异有统计学意义(P<0.05);联合组HBV-DNA转阴率高于活菌组、扶正化瘀组,扶正化瘀组高于活菌组,差异有统计学意义(P<0.05);三组HBV-DNA、TBIL、AST、ALT、Ⅳ-C、PC-Ⅲ、LN、HA、IL-8、TNF-α、hs-CRP、IL-6水平低于治疗前,联合组低于活菌组和扶正化瘀组,差异有统计学意义(P<0.05)。【结论】 扶正化瘀胶囊与双歧杆菌三联活菌辅助替诺福韦治疗老年HBC效果显著,能改善患者肝功能,抑制肝纤维化,抑制机体炎症反应。

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	徐娟
	李小雪

关键词 ：乙型肝炎/并发症, 肝硬化/病因学, 扶正化瘀胶囊/治疗应用, 乳杆菌属/治疗应用

Abstract：【Objective】 To study the effect of Fuzheng Huayu Capsule and bifidobacterium triple viable bacteria combined with tenofovir on liver fibrosis and platelets in elderly patients with hepatitis B cirrhosis (HBC). 【Methods】 A total of 93 elderly HBC patients admitted to our hospital from April 2019 to April 2021 were selected as the research objects. Patients were divided into the Fuzheng Huayu group (31 cases), the viable bacteria group (31 cases) and The combined group (31 cases) by random number table method. The three groups were all given tenofovir. In addition, the Fuzheng Huayu group was given Fuzheng Huayu Capsules, the viable bacteria group was given bifidotriple viable bacteria, and the combination group was given Fuzheng Huayu Capsule + Bifidobacterium triple viable bacteria. The HBV DNA quantification (HBV-DNA), HBV-DNA negative convert rate, liver function indexes [alanine aminotransferase (ALT), total bilirubin (TBIL), aspartate aminotransferase (AST)], liver fibrosis indicators [type Ⅲ procollagen (PC-Ⅲ), hyaluronic acid (HA), laminin (LN), type Ⅳ collagen (Ⅳ-C)] and serum inflammatory factors [tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), interleukin-8 (IL-8)] were compared among the three groups. 【Results】 After treatment, the levels of HBV-DNA in the three groups were lower than those before treatment. The HBV-DNA level in the combination group was lower than that in the bifidotriple viable bacteria group and the Fuzheng Huayu group. While the Fuzheng Huayu group was lower than the live bacteria group. The difference were statistically significant (P<0.05).The negative rate of HBV-DNA in the combined group (93.55%) was higher than that in the viable bacteria group (70.97%) and the Fuzheng Huayu group (64.52%) (P<0.05). After treatment, the three groups of HBV-DNA, TBIL, AST, ALT , Ⅳ-C, PC-Ⅲ, LN, HA, IL-8, TNF-α, hs-CRP, IL-6 levels were lower than those before treatment; And the combined group was lower than the viable bacteria group and the Fuzheng Huayu group (P<0.05). 【Conclusion】 Fuzheng Huayu Capsules and bifidobacterium triple viable bacteria combined with tenofovir have significant effects in the treatment of elderly HBC, which can improve liver function, inhibit liver fibrosis, improve blood coagulation function, and inhibit inflammatory symptoms of the body.

Key words： Hepatitis B/CO Liver Cirrhosis/ET Fuzheng Huayu Jiaonang/TU Lactobacillus/TU

收稿日期: 2022-06-20

中图分类号:

R657.31

引用本文:

徐娟, 李小雪. 扶正化瘀胶囊与双歧杆菌三联活菌辅助替诺福韦对老年乙肝肝硬化患者肝纤维化程度的影响[J]. 医学临床研究, 2023, 40(1): 108-111.
XU Juan, LI Xiao-xue. Effects of Fuzheng Huayu Capsule and Bifidotriple Viable Bacteria Assisted by Tenofovir on Liver Fibrosis in Elderly Patients with Hepatitis B Cirrhosis. JOURNAL OF CLINICAL RESEARCH, 2023, 40(1): 108-111.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2023.01.032 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2023/V40/I1/108

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