Abstract：【Objective】To investigate the correlation of serum golgi protein 73 (GP73),ceruloplasmin (CER) and liver stiffness/hardness (LSM) with liver fibrosis stage in chronic hepatitis B (CHB) patients with slightly elevated alanine aminotransferase (ATL).【Methods】A total of 122 CHB patients were selected as the observation group.In addition,100 healthy volunteers were selected as the control group.CER,GP73 and LSM levels were compared between the two groups.And levels of CER,GP73 and LSM were compared in CHB patients with different stages of liver fibrosis as well.The diagnostic value of CER,GP73 and LSM in CHB diagnosis and their relationship with liver fibrosis stage were determined by ROC and correlation analysis.【Results】The CER level in the observation group was significantly lower than that in the control group (P<0.05).The levels of GP73 and LSM in the observation group were significantly higher than those in the control group (P<0.05).ROC analysis confirmed that the areas under the curve of CER,GP73 and LSM for CHB diagnosis were 0.718,0.859 and 0.905,respectively (P<0.05).The value of CER in CHB patients with different stages of liver fibrosis was S1>S2>S3>S4,and the differences were statistically significant (P<0.05).While the levels of GP73 and LSM in CHB patients with different stages of liver fibrosis were S1<S2<S3<S4,and the differences were statistically significant (P<0.05).Correlation analysis confirmed that CER was negatively correlated with liver fiber staging in CHB patients,while GP73 and LSM were positively correlated with liver fiber staging in CHB patients (all P<0.05).【Conclusion】CER of CHB patients with ALT≤2× upper limit of normal value (ULN) decreased significantly,while GP73 and LSM increased significantly.Thus these changes can be used for disease diagnosis.They are closely related to the severity of liver fibrosis,which is worthy of clinical attention.
李丹杰, 韦晓强. 血清CER、GP73及肝脏硬度值与ATL轻度升高乙肝患者肝纤维化分期的相关性[J]. 医学临床研究, 2022, 39(9): 1332-1335.
LI Dan-jie, WEI Xiao-qiang. Correlation of CER,GP73 and Liver Hardness with Hepatic Fibrosis Stage in Chronic Hepatitis B Patients with Slightly Elevated ATL. JOURNAL OF CLINICAL RESEARCH, 2022, 39(9): 1332-1335.
[1] WANG X Y,WEN Y M.A "sandwich" strategy for functional cure of chronic hepatitis B[J].Emerg Microbes Infect,2018,7(1):91.
[2] 李明慧,胡蕾苹,张璐,等.HBeAg阳性慢性乙型肝炎用核苷(酸)类似物治疗部分病毒学应答患者转换聚乙二醇干扰素α-2a治疗的研究[J].中华肝脏病杂志,2015,23(11):826-831.
[3] 中华医学会肝病学分会,中华医学会感染病学分会.慢性乙型肝炎防治指南(2015更新版)[J].中华肝脏病杂志,2015,23(12):888-905.
[4] 应筱雯,俞莹,刘雯,等.血清高尔基体蛋白73水平与肝纤维化相关性分析[J].标记免疫分析与临床,2018,25(2):186-191.
[5] 谭立明.血清CER、HA和FT3对慢性乙型肝炎肝纤维化的诊断价值[J].解放军医学杂志,2020,45(6):646-650.
[6] MAURO E,CRESPO G,LONDOO M C,et al.Noninvasive assessment of liver fibrosis and portal hypertension after viral eradication in post-transplant hepatitis C[J].J Hepatol,2017,66(1):237.
[7] 曾民德,王泰龄.肝纤维化诊断及疗效评估共识[J].中华肝脏病杂志,2002,10(5):327-328.
[8] LU X J,LI X H,YUAN Z X,et al.Assessment of liver fibrosis with the gamma-glutamyl transpeptidase to platelet ratio:a multicentre validation in patients with HBV infection[J].Gut,2017,67(10):1903-1904.
[9] 高伟,侯勇.肝脏硬度值检测诊断慢性乙型肝炎患者肝组织纤维化的效能分析[J].实用肝脏病杂志,2019,22(5):652-655.
[10] 张继旺,唐治贵,袁永强.病毒性肝炎慢性HBV携带者血清中肝功能相关蛋白检测的临床意义[J].临床肝胆病杂志,2015,31(4):520-522.
[11] 程华,鞠辉,宋德顺,等.慢性乙型肝炎患者血清血管生成素样蛋白2和高尔基体蛋白73水平变化及其诊断显著肝纤维化的效能分析[J].实用肝脏病杂志,2019,22(4):494-497.
[12] LIU T,YAO M,LIU S,et al.Serum Golgi protein 73 is not a suitable diagnostic marker for hepatocellular carcinoma[J].Oncotarget,2017,8(10):16498-16506.
[13] 张小曼,魏梅娟,许正锯,等.血清甲胎蛋白、白细胞介素-6和高尔基体蛋白73在肝脏疾病中的表达特点及其对肝细胞癌的诊断价值[J].中华实验和临床感染病杂志(电子版),2017,11(4):339-344.
[14] 丁荣蓉,陆伟,王雁冰,等.采用FibroScan和天冬氨酸转氨酶与血小板比值指数评估慢性乙型肝炎患者肝纤维化程度[J].中华传染病杂志,2017,35(8):467-471.
2022, Vol. 39 
