Clinical Efficacy of Modified TiaomianxiaozhengDecoction Combined with Conventional Western Medicinein the Treatment of Cervical High Risk HPV Persistent Infection
LI Xi-sheng, HE Jing
Department of Traditional Chinese Medicine, Yan'an People's Hospital, Yan'an Shaanxi 716000
摘要【目的】探讨调免消癥汤加减联合常规西医治疗宫颈高危人乳头瘤病毒(high-risk human papilloma virus,HR-HPV)持续感染的临床疗效。【方法】94例宫颈HR-HPV持续感染(脾虚湿盛证)患者,按照随机数字表法分为观察组和对照组,每组47例。对照组采用常规治疗,观察组在对照组基础上加用调免消癥汤加减治疗。对比两组治疗前后中医症状评分、HPV病毒载量、T淋巴细胞亚群变化情况及中医疗效、HR-HPV转阴率、临床疗效、治疗期间不良反应发生情况。【结果】治疗后,两组中医症状评分、HPV病毒载量和Th17/Treg均降低(P<0.05),CD3+、CD4+和CD4+/CD8+均升高(P<0.05);与对照组相比,观察组治疗后中医症状评分、HPV病毒载量和Th17/Treg均降低(P<0.05),CD3+、CD4+和CD4+/CD8+ 均升高(P<0.05);观察组中医总有效率、HR-HPV转阴率、临床总有效率均显著高于对照组(P<0.05);两组治疗期间不良反应发生率比较差异无统计学意义(P>0.05)。【结论】采用调免消癥汤加减联合常规西医治疗宫颈HR-HPV持续感染患者,可缓解患者症状,降低HPV病毒载量,并可调节免疫功能,疗效显著,且安全性高,值得临床推广应用。
Abstract：【Objective】To explore the effect of modified Tiaomianxiaozheng decoction on cervical high risk human papilloma virus (HR-HPV) persistent infection (spleen deficiency and dampness excess syndrome).【Methods】A total of 94 patients with persistent cervical HR-HPV infection (spleen deficiency and dampness syndrome) were randomly divided into 2 groups with 47 cases in each group. The control group received western medicine treatment, and the observation group was treated with Tiaomianxiaozheng decoction in addition to conventional basis. The traditional Chinese medical(TCM) symptom score, the curative effect of TCM, HPV viral loads and the changes of T lymphocyte subsets of the two groups before and after treatment were compared. The negative HPV conversion rate, clinical efficacy and the incidence of adverse reactions during treatment were compared.【Results】After treatment, the TCM symptom score, HPV viral load and Th17/Treg of the two groups were decreased (P<0.05), CD3+, CD4+ and CD4+/CD8+ were all increased (P<0.05). Compared with the control group, the TCM symptom score, HPV viral load and Th17/Treg of the observation group after treatment were all lower (P<0.05), and CD3+, CD4+ and CD4+/CD8+ were all higher (P<0.05). The total effective rate of TCM, HPV negative conversion rate and total clinical effective rate in the observation group were higher than those in the control group (P<0.05).The incidence of adverse reactions between the two groups during treatment was not different (P>0.05).【Conclusion】Modified Tiaomianxiaozheng decoction combined with conventional western medicine is used to treat HR-HPV persistent infection patients with spleen deficiency and dampness excess syndrome, which can significantly promote the remission of symptoms, reduce the load of HPV virus, regulate the immune function and improve the clinical efficacy. It has obvious curative effect and high safety.
李昔胜, 何静. 调免消癥汤加减联合常规西医治疗宫颈高危HPV持续感染的临床疗效[J]. 医学临床研究, 2022, 39(3): 378-381.
LI Xi-sheng, HE Jing. Clinical Efficacy of Modified TiaomianxiaozhengDecoction Combined with Conventional Western Medicinein the Treatment of Cervical High Risk HPV Persistent Infection. JOURNAL OF CLINICAL RESEARCH, 2022, 39(3): 378-381.
2022, Vol. 39 
