血清MMP-2、MMP-9、IL-17表达与妊娠期肝内胆汁淤积症发生的相关性分析

doi:10.3969/j.issn.1671-7171.2022.09.009

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摘要【目的】探讨血清基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-9(MMP-9)、白介素-17(IL-17)与妊娠期肝内胆汁淤积症(ICP)发生的关系。【方法】选取2020年1月至2022年1月在乾县中医医院住院并分娩的75例ICP患者(ICP组),并选取同期在本院住院并分娩且无妊娠并发症的75例正常孕产妇(对照组)。比较两组血清MMP-2、MMP-9、IL-17、总胆红素(TBIL)、直接胆红素(DBIL)水平,采用受试者工作特征(ROC)曲线分析血清MMP-2、MMP-9、IL-17、TBIL、DBIL评估妊娠期发生ICP的价值。根据病情严重程度将75例ICP患者为轻症组(n=45)与重症组(n=30),比较不同病情严重程度患者血清MMP-2、MMP-9、IL-17、TBIL、DBIL水平,通过Spearman相关系数分析血清MMP-2、MMP-9、IL-17、TBIL、DBIL水平与ICP患者严重程度的关系。【结果】ICP组血清MMP-2、MMP-9、IL-17、TBIL、DBIL水平均显著高于对照组,差异有统计学意义(P<0.05); ROC曲线分析显示: MMP-2≥176.277 ng/mL、MMP-9≥679.489 ng/mL、IL-17≥12.597 pg/mL、TBIL≥13.208 μmol/L、DBIL≥3.998 μmol/L是评估妊娠期发生ICP的最佳截断值;轻症组血清MMP-2、MMP-9、IL-17、TBIL、DBIL水平均显著低于重症组,其差异有统计学意义(P<0.05);相关性分析显示:ICP患者病情严重程度与血清MMP-2、MMP-9、IL-17、TBIL、DBIL水平呈正相关(均P<0.05)。【结论】血清MMP-2、MMP-9、IL-17水平与ICP发生密切相关,且与ICP严重程度呈正相关。

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关键词 ：胆汁淤积,肝内, 妊娠并发症, 基质金属蛋白酶9/分析, 基质金属蛋白酶2/分析, 白细胞介素17/分析

Abstract：【Objective】To study the relationship of intrahepatic cholestasis of pregnancy (ICP) with matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), interleukin-17 (IL-17). 【Methods】A total of 75 ICP patients who were hospitalized and delivered in Qian County Hospital of Traditional Chinese Medicine from January 2020 to January 2022 were selected as the ICP group, and 75 normal pregnant women who were hospitalized and delivered without pregnancy complications in our hospital during the same period were selected as the control group. The levels of serum MMP-2, MMP-9, IL-17, total bilirubin (TBIL) and direct bilirubin (DBIL) were compared between the two groups. The value of ICP in pregnancy was evaluated by ROC analysis of serum MMP-2, MMP-9, IL-17, TBIL and DBIL. All 75 ICP patients were divided into the mild group (n=45) and the severe group (n=30) according to the severity of the disease. The levels of serum MMP-2, MMP-9, IL-17, TBIL, DBIL in patients with different severity of the disease were compared. The relationship of the severity of ICP patients with serum MMP-2, MMP-9, IL-17, TBIL and DBIL was analyzed by Spearman correlation coefficient. 【Results】Serum levels of MMP-2, MMP-9, IL-17, TBIL and DBIL in the ICP group were significantly higher than those in control group (P<0.05). ROC curve analysis showed that MMP-2 ≥ 176.277 ng/mL, MMP-9 ≥ 679.489 ng/mL, IL-17 ≥ 12.597 pg/mL, TBIL ≥ 13.208 μmol/L and DBIL≥3.998 μmol/L were the best cut-off value to evaluate ICP during pregnancy (all P<0.05). Serum levels of MMP-2, MMP-9, IL-17, TBIL and DBIL in the mild group were significantly lower than those in the severe group (P<0.05). Through correlation analysis, the severity of ICP patients was positively correlated with serum MMP-2, MMP-9, IL-17, TBIL and DBIL levels (P<0.05). 【Conclusion】Serum levels of MMP-2, MMP-9 and IL-17 are closely related to the occurrence of ICP, and they are positively related to the severity of ICP as well.

Key words： Cholestasis,Intrahepatic Pregnancy Complications Matrix Metalloproteinase 9/AN Matrix Metalloproteinase 2/AN Interleukin-17/AN

收稿日期: 2022-03-10

中图分类号:

R575

通讯作者: *E-mail:996355962@qq.com

引用本文:

文关良, 剌梅, 方德春. 血清MMP-2、MMP-9、IL-17表达与妊娠期肝内胆汁淤积症发生的相关性分析[J]. 医学临床研究, 2022, 39(9): 1311-1314.
WEN Guan-liang, LA Mei, FANG De-chun. Correlation Analysis of Risk of Intrahepatic Cholestasis of Pregnancy with Expression of Serum MMP-2, MMP-9 and IL-17. JOURNAL OF CLINICAL RESEARCH, 2022, 39(9): 1311-1314.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.09.009 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I9/1311

[1] JURK S M,KREMER A E,SCHIEUSSNER E.Intrahepatic cholestasis of pregnancy[J].Geburtshilfe Frauenheilkd,2021,81(8):940-947.
[2] VASAVAN T,DEEPAK S,JAYAWARDANE I A,et al.Fetal cardiac dysfunction in intrahepatic cholestasis of pregnancy is associated with elevated serum bile acid concentrations[J].J Hepatol,2020,37(3):144-149.
[3] 周丽琴,陈洁,吴惠,等.妊娠肝内胆汁淤积症患者总胆汁酸水平与胎儿窘迫的相关性分析[J].中国医药导报,2020,17(33):110-113.
[4] 中华医学会妇产科学分会产科学组.妊娠期肝内胆汁淤积症诊疗指南(2015)[J].临床肝胆病杂志,2015,46(10):1575-1578.
[5] JELSKI W,PIECHOTA J,ORYWAL K,et al.The alterations in alcohol dehydrogenase activity in the sera of women with intrahepatic cholestasis of pregnancy[J].Anticancer Res,2020,40(4):1997-2001.
[6] MONROSE E,BUI A,ROSENBLUTH E,et al.High burden of future liver disease in intrahepatic cholestasis of pregnancy patients[J].J Hepatol,2020,73(6):540-542.
[7] WALKER K F,CHAPPELL L C,HAGUE W M,et al.Pharmacological interventions for treating intrahepatic cholestasis of pregnancy[J].Cochrane Database Syst Rev,2020,7(2):459-463.
[8] 李阳芳,程群仙,李航,等.妊娠期肝内胆汁淤积症孕妇总胆汁酸水平与妊娠不良结局研究[J].肝脏,2019,24(7):817-818.
[9] CHEN L,LIN G,CHEN K,et al.VEGF promotes migration and invasion by regulating EMT and MMPs in nasopharyngeal carcinoma[J].J Cancer,2020,11(24):7291-7301.
[10] 马波,李伟伟,闫雅妮,等.绒毛中IGF2及MMP-9表达水平与早期妊娠胚胎停止发育的相关性研究[J].中国性科学,2020,29(2):47-50.
[11] 桂凌,曾玉,陈亚军,等.孕妇血清基质金属蛋白酶-2和基质金属蛋白酶-9水平变化与不良妊娠结局的相关性[J].中国妇幼保健,2021,36(3):1233-1235.
[12] 刘秋霞,张慧雅.血清MMP-2和MMP-9水平检测作为诊断妊娠期肝内胆汁淤积症新的生物标志物的价值研究[J].现代检验医学杂志,2019,34(3):82-85.
[13] 杨燕,蒋敏,刘雪琼,等.T细胞免疫球蛋白黏蛋白分子-3-半乳糖凝集素-9通路维持妊娠免疫耐受的作用[J].中华围产医学杂志,2020,23(8):1364-1368.
[14] 蒋铁根,郑丽.小剂量地塞米松辅助治疗妊娠期肝内胆汁淤积症对NLR和PLR值及肝功能的影响[J].肝脏,2021,26(6):478-479.
[15] 邬瑞霞,雷蔚华,龚景进,等.妊娠期肝内胆汁淤积症患者血清总胆汁酸水平与炎症因子、Th17/Treg平衡及母婴结局的关系研究[J].现代生物医学进展,2021,21(13):2560-2563.
[16] 杜珍,唐小军,陶芸,等.双重血浆吸附系统联合血浆置换对慢加急性肝功能衰竭患者肝肾功能的影响[J].医学临床研究,2021,38(6):932-935.
[17] 李俊林,许旭,卢霞,等.血清脂肪细胞型脂肪酸结合蛋白水平与妊娠期肝内胆汁淤积症的相关性[J].中国医药,2021,16(2):271-275.