Abstract：【Objective】To investigate the correlation of macrophage inhibitory factor 1 (MIC-1),cytokeratin19 soluble fragment (CYFRA21-1),tumor mutational burden (TMB) and related clinical characteristics with the efficacy of targeted therapy for advanced non-small cell lung cancer (NSCLC).【Methods】The clinical data of 118 patients with advanced NSCLC admitted to our hospital were collected and divided into the chemotherapy effective group (n=55) and the chemotherapy ineffective group (n=63) according to the short-term efficacy.The differences of general data and laboratory indicators (MIC-1,CYFRA21-1,TMB) between the two groups were compared.The value of MIC-1 and CYFRA21-1 in predicting the efficacy of advanced NSCLC was analyzed by ROC.The differences between the two groups were included in the multivariate Logistic regression analysis to identify the risk factors affecting the efficacy of advanced NSCLC.【Results】After treatment,10 patients had complete remission,45 patients had partial remission,41 patients had stable disease,and 22 patients had progressive disease.The total effective rate was 46.61% (55/118).There were no significant differences in gender,body mass index (BMI),tumor diameter and drinking history between the two groups (P>0.05).The proportion of patients with ≥60 years old,squamous cell carcinoma,poorly differentiated,TNM stage Ⅳ,smoking history,moderate or low TMB level in the chemotherapy ineffective group was significantly higher than that in the chemotherapy effective group (P<0.05).ROC analysis confirmed that MIC-1 and CYFRA21-1 could be used to predict the efficacy of advanced NSCLC,and the areas under the curve were 0.798 and 0.801,respectively (both P<0.05).Multivariate Logistic regression analysis confirmed that ≥60 years old,squamous cell carcinoma,low differentiation,TNM stage Ⅳ,smoking history,moderate to low TMB level,MIC-1≥1030.030 pg/mL,CYFRA21-1≥9.095 μg/mL were risk factors affecting the efficacy of targeted therapy for advanced NSCLC (P<0.05).【Conclusion】The level of TMB in tumor tissue and the efficacy of targeted therapy for advanced NSCLC are affected by many factors,such as age,pathological type,degree of differentiation,TMB level in tumor tissue,MIC-1,CYFRA21-1,etc.Clinicians should pay close attention to them when treating advanced NSCLC.
李国霞, 刘向玲. MIC-1、CYFRA21-1、TMB水平与晚期非小细胞肺癌靶向治疗疗效的相关性[J]. 医学临床研究, 2022, 39(9): 1307-1310.
LI Guo-xia, LIU Xiang-ling. Correlation of MIC-1,CYFRA21-1 and TMB Levels with Efficacy of Targeted Therapy for Advanced Non-small Cell Lung Cancer. JOURNAL OF CLINICAL RESEARCH, 2022, 39(9): 1307-1310.
2022, Vol. 39 
