Abstract：【Objective】 To investigate the expression of serum fibroblast growth factor 21 (FGF-21) and Apelin in pregnant patients with hypothyroidism and correlation with blood lipids and low-birthweight neonates. 【Methods】 From January 2018 to June 2019, 85 patients with hypothyroidism during pregnancy were selected as the observation group, and 90 normal pregnant women were selected as the control group. Thyroid hormone levels, blood lipid levels, serum FGF-21, Apelin expression levels were compared between the two groups, and the correlation of serum FGF-21 and Apelin expression levels with blood lipid and low birth weight was analyzed. 【Results】 The TSH level of the observation group was significantly higher than that of the control group (P<0.05), while the levels of FT3 (free triiodothyronine) and FT4 (free thyroxine) were significantly lower than those in the control group (P<0.05). The levels of FGF-12, Apelin, TG, TC and HDL in the observation group were significantly higher than those in the control group (P<0.05), and the level of LDL in the observation group was significantly lower than that in the control group (P<0.05). The incidence of low birth weight newborns in the observation group was 2.35% (2/85), which was lower than 10.00%(9/90) in the control group. The difference was statistically significant between the two groups (χ2=4.340,P=0.037). The results of correlation analysis showed that serum FGF-21 and Apelin levels in pregnant women with hypothyroidism were was positively correlated with TG, TC and the incidence of low neonatal weight (P<0.05), negatively correlated with LDL (P<0.05) and not significantly correlated with HDL (P> 0.05). 【Conclusion】 Serum Apelin and FGF-21 expression levels increased in patients with hypothyroidism during pregnancy, and the expression levels of Apelin and FGF-21 were positively correlated with lipid metabolism indicators such as TG and TC. It may participate in the occurrence and development of the disease by affecting the patient's metabolic level, and ultimately affect the perinatal outcome.
杨菊梅, 李永莉. FGF-21、Apelin在妊娠合并甲减患者血清中的水平表达及其与血脂水平、低体重新生儿发生率的相关性分析[J]. 医学临床研究, 2021, 38(5): 724-726.
YANG Ju-mei, LI Yong-li. Expression of Serum FGF-21 and Apelin in Pregnant Women with Hypothyroidism and Correlation with Blood Lipids and Low Birth Weight Neonates. JOURNAL OF CLINICAL RESEARCH, 2021, 38(5): 724-726.
2021, Vol. 38 
