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医学临床研究  2021, Vol. 38 Issue (5): 677-679    DOI: 10.3969/j.issn.1671-7171.2021.05.011
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结肠癌组织中MMP-9、MIG、FLNa的表达水平与患者预后的相关性
尹超, 王瑜鹏**
陕西省第四人民医院普外科,陕西 西安 710043
Relationship of MMP-9, MIG and Fibroin A Expression with Prognosis of Colon Cancer
YIN Chao, WANG Yu-peng
Department of General Surgery, The Fourth People's Hospital of Shaanxi, Xi'an Shaanxi, 710043
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摘要 【目的】 观察结肠癌组织中细丝蛋白A(FLNa)、基质金属蛋白酶9(MMP-9)以及迁移诱导蛋白-7(MIG-7)的表达阳性情况及其与病理因素及无病生存期(DFS)的关系。【方法】 本院收治的160例可手术的结肠癌患者,取其术后结肠癌组织,用免疫组化法对癌组织及癌旁组织中MMP-9、FLNa、MIG-7表达情况进行检测,观察MMP-9、FLNa、MIG-7表达与结肠癌病理因素和DFS的相关性。【结果】 相比癌旁组织,癌组织中MMP-9、MIG-7表达上调(P<0.05),FLNa表达下调(P<0.05)。相比Ⅰ~Ⅱ期、非淋巴结转移及无脉管浸润患者,Ⅲ期、淋巴结转移、脉管浸润的结肠癌患者组织中MMP-9、MIG-7表达上调(P<0.05),FLNa表达下调(P<0.05)。中位随访时间18.9个月,复发25例,转移20例,死亡9例。COX多因素分析显示,MMP-9、MIG-7、FLNa、TNM分期、淋巴结转移是结肠癌患者DFS的独立影响因素(P<0.05)。【结论】 结肠癌中MMP-9、MIG-7表达上调,FLNa表达下调,且与病理因素及DFS相关。
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尹超
王瑜鹏
关键词 结肠肿瘤/病理学基质金属蛋白酶9/分析细丝蛋白/分析预后    
Abstract【Objective】 To investigate the relationship of matrix metalloproteinase-9 (MMP-9), migration-inducible protein-7 (MIG-7) and fibroin A (FLNa) expression with pathological factors and disease-free survival (DFS) in patients with colon cancer. 【Methods】 A total of 160 patients with colon cancer admitted to the Fourth People's Hospital of Shaanxi Province for surgery were selected. The postoperative colon cancer tissues was collected to detect MMP-9, MIG-7and FLNa expression by immunohistochemistry in cancer tissues and adjacent tissues. The correlation of MMP-9, FLNa and MIG-7 expression with colon cancer pathological factors and DFS was analyzed. 【Results】 Compared to colon cancer adjacent tissues, the expression levels of MMP-9 and MIG-7 were up-regulated (P<0.05), while the expression level of FLNa was down-regulated (P<0.05). Compared to patients with stage Ⅰ-Ⅱcolon cancer, non-lymph node metastasis and no vascular invasion, the expression levels of MMP-9 and MIG-7 in the tissues of colon cancer patients with stage Ⅲ, lymph node metastasis, and vascular invasion were up-regulated (P<0.05), and the expression of FLNa was down-regulated (P<0.05). The median follow-up time was 18.9 months. There were 25 relapses, 20 metastases, and 9 deaths. COX multivariate analysis showed that MMP-9, MIG-7, FLNa, TNM staging and lymph node metastasis were independent influencing factors of DFS in colon cancer patients (P<0.05). 【Conclusion】 The expression levels of MMP-9 and MIG-7 are up-regulated in colon cancer, and the expression of FLNa is down-regulated. These gene expression levels are related to pathological factors and DFS in colon cancer patients.
Key wordsColonic Neoplasms/PA    Matrix Metalloproteinase 9/AN    Filamins/AN    Prognosis
收稿日期: 2020-05-12     
中图分类号:  R735.35  
基金资助:陕西省卫生健康科研基金项目(2018D034)
通讯作者: **E-mail:158432412@qq.com   
引用本文:   
尹超, 王瑜鹏. 结肠癌组织中MMP-9、MIG、FLNa的表达水平与患者预后的相关性[J]. 医学临床研究, 2021, 38(5): 677-679.
YIN Chao, WANG Yu-peng. Relationship of MMP-9, MIG and Fibroin A Expression with Prognosis of Colon Cancer. JOURNAL OF CLINICAL RESEARCH, 2021, 38(5): 677-679.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2021.05.011     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2021/V38/I5/677
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