Abstract：【Objective】 To investigate the effect of nano knife ablation combined with percutaneous transhepatic biliary drainage (PTCD) on the prognosis and liver function of unresectable hilar cholangiocarcinoma in the elderly. 【Methods】 The clinical data of 72 elderly patients with unresectable hilar cholangiocarcinoma treated in the Ninth People's Hospital Affiliated to the Medical College of Shanghai Jiaotong University were analyzed retrospectively. According to different surgical treatment schemes, they were divided into control group (PTCD alone, n=40) and observation group (nano knife ablation combined with PTCD, n=32). The changes of glycogen (CEA), total bilirubin (CEA) and aminotransferase (ALT) before and after treatment were compared between the two groups. 【Results】 The tumor remission rate in the observation group was 87.50% (28/32), which was significantly higher than 65.00% (26/40) in the control group (P<0.05). After treatment, the levels of alt, AST and TBIL in the two groups were lower than those before treatment, and the levels in the observation group were lower than those in the control group (P<0.05); The levels of CA199, CA125 and CEA in the observation group were lower than those in the control group (P<0.05). The incidence of complications in the observation group was 21.87% (7/32), which was lower than 12.50% (5/40) in the control group. The difference was not statistically significant (χ2=1.13,P=0.29>0.05). The 2-year survival rate of the observation group was 38.70%, which was higher than 27.02% of the control group, but the difference was not statistically significant (Log Rank=1.473,P=0.225). 【Conclusion】 Nano knife ablation combined with PTCD in the treatment of elderly unresectable hilar cholangiocarcinoma has a good prognosis and can improve liver function, which is worthy of popularization.
胡佩俊, 薛英. 纳米刀消融联合PTCD术治疗老年不可切除肝门部胆管癌患者预后及肝功能的影响[J]. 医学临床研究, 2022, 39(5): 717-720.
HU Pei-jun, XUE Ying. Effect of Nano Nnife Ablation Combined with PTCD on Prognosis and Liver Function in Elderly Patients with Unresectable Hilar Cholangiocarcinoma. JOURNAL OF CLINICAL RESEARCH, 2022, 39(5): 717-720.
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2022, Vol. 39 
