Abstract：【Objective】 To investigate the analgesic effect of dexmedetomidine (Dex) combined with dextrozine in laparoscopic cholecystectomy(LC). 【Methods】 A total of 90 patients undergoing LC in our hospital from June 30, 2017 to June 30, 2019 were randomly divided into the Dex group, the combination group (Dex combined with dextrozine) and the control group, with 30 cases in each group. The operation time, propofol dosage, recovery time and postoperative adverse reactions were recorded in the three groups. The heart rate (HR) and mean arterial pressure (MAP) at different times during operations (before surgery, after pneumoperitoneum, the moment of gallbladder excision, and the moment of laryngeal mask removal) were measured and recorded. The postoperative pain (VAS score) and sedation (Ramsay score) were compared among the 3 groups. Blood glucose, cortisol, and blood norepinephrine (NE) levels were compared as well before and after surgery. 【Results】 The dosage of propofol and sufentanil in the combination group was lower than that in the Dex group and the control group (P<0.05), but there were no significant differences in the operation time and recovery time among the three groups (P>0.05). There was no statistically significant difference in the incidence of adverse reactions between the three groups (P>0.05). The VAS scores at 1, 6, 12, and 24 h after operation were lower in the combination group than in the control group and the Dex group (P<0.05). The Ramsay scores at 1, 6 h after operation of the combination group were higher than those of the control group and the Dex group (P<0.05). There were no significant differences in HR and MAP among the three groups before operation, after pneumoperitoneum, and at the moment of the gallbladder excision (P>0.05). When the laryngeal mask was pulled, the HR and MAP in the combined group were lower than those in the control group and the Dex group (P<0.05). At the end of the operation, the blood glucose, cortisol and NE in the combined group were lower than those in the control group and the Dex group (P<0.05). 【Conclusion】 Dexmedetomidine combined with dextrozine has significant analgesic and sedative effects during laparoscopic cholecystectomy, which can also reduce the stress response. It is pretty safe for LC.
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2020, Vol. 37 
