Abstract：【Objective】 To explore the analgesic effect and stress response of multimodal analgesia in the application of laparoscopic hysteromyomectomy.【Methods】 A total of 100 patients with uterine leiomyoma admitted to our hospital were divided into the observation group and the control group by random table method, with 50 cases in each group. Laparoscopic hysteromyomectomy was performed in both groups. The control group received routine general anesthesia plus post-operative PCIA, while the observation group received multimodal analgesia. The pain score of visual analogue scale (VAS), the amount of analgesics used at different time and the pressing times of analgesic pumps were recorded and compared between the two groups. Postoperative stress response indicators such as angiotensin Ⅱ(AngⅡ), cortisol (Cor), corticotropin releasing hormone (CRH), norepinephrine (NE) levels were measured in both groups.The adverse reactions were also compared in the two groups.【Results】 The pain scores of the observation group at 2, 4, 12, 24 and 48 hours after treatment were lower than those of the control group (P<0.05).The dosage of analgesics and the number of pressing analgesic pumps in the observation group were lower than those in the control group at 12h, 24h and 36h after treatment (P<0.05). AngⅡ, Cor, CRH and NE levels in the observation group were significantly lower than those in the control group (P<0.05).The total incidence of adverse reactions in the two groups was not significant difference (P>0.05).【Conclusion】 The analgesic effect of multimodal analgesia in laparoscopic hysteromyomectomy is remarkable. It can reduce stress response which has high clinical application value.
2020, Vol. 37 
