Abstract：【Objective】 To investigate the application of serum tumor markers combined with bone marrow morphometry in patients with lymphoma. 【Methods】 A total of 52 patients with lymphoma in our hospital were selected as the observation group (including 22 cases with tumor infiltration and 30 cases with non-infiltration). At the same time, 52 healthy volunteers were selected as the control group. The levels of serum ferritin (SF), carcinoembryonic antigen 15-3 (CA15-3), carcinoembryonic antigen 125 (CA125), carcinoembryonic antigen (CEA), clinical data and cell morphology were compared between the two groups. 【Results】 (1) The levels of SF, CA15-3, CA125 and CEA in the observation group were higher than those in the control group (P<0.05). The levels of SF, CA15-3, CA125 and CEA in patients with tumor infiltration were higher than those with non-invasive infiltration (P<0.05). (2) Serum SF, CA15-3, CA125, CEA had no correlation with age, gender, WBC, HGB, PLT, lymphocyte proportion (P>0.05), while serum CA15-3, CA125 had correlation with infant lymphocyte proportion (P<0.05), serum SF, CA15-3, CA125, CEA had correlation with lymphoma B symptoms (P<0.05), serum SF and CA15-3 had correlation with lymphoma stage (P<0.05), serum SF, CA15- 3 and CA125 were correlated with international prognostic index (IPI) (P<0.05). 【Conclusion】 Serum tumor markers combined with bone marrow morphometry can be helpful to the diagnosis, staging, and prognosis of lymphoma, and provide a reliable reference for the diagnosis of bone marrow infiltration. It has important clinical significance.
2020, Vol. 37 
