MMP-9、MMP-2、MIG-7、FLNa在结肠癌中的表达及意义

doi:10.3969/j.issn.1671-7171.2020.06.020

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (0 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要【目的】观察基质金属蛋白酶9(MMP-9)、基质金属蛋白酶2(MMP-2)、细丝蛋白A(FLNa)、迁移诱导蛋白-7(MIG-7)在结肠癌中的表达情况,并分析其与结肠癌临床病理因素、预后的相关性。【方法】在本院接受手术切除的120例结肠癌患者,取其术后癌组织及癌旁组织检测(免疫组化法)MMP-9、MMP-2、FLNa、MIG-7的表达情况,分析其与患者临床病理因素、预后的关系。【结果】癌组织MMP-9、MMP-2、MIG-7阳性率较癌旁组织高,FLNa阳性率较癌旁组织低,且差异均有显著性(P<0.05)。MMP-9、MMP-2、MIG-7表达阳性患者淋巴结转移率、TNM Ⅲ期比例、脉管浸润率、中低分化比例高于表达阴性患者(P<0.05),FLNa表达阳性患者淋巴结转移率、Ⅲ期比例、脉管浸润率、中低分化比例低于表达阴性患者(P<0.05)。中位随访时间26个月,死亡22例。COX多因素分析结果显示,TNM分期、FLNa、MIG-7、MMP-2、MMP-9、肿瘤分化程度、淋巴结转移是生存率独立影响因素。【结论】结肠癌组织中MMP-9、MMP-2、MIG-7高表达,FLNa低表达。FLNa、MIG-7、MMP-2、MMP-9表达与肿瘤浸润及预后相关。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	杨华
	侯静芳

关键词 ：结肠肿瘤/病理学, 基质金属蛋白酶9/血液, 基质金属蛋白酶2/血液

Abstract：【Objective】To investigate the expression of matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase 2 (MMP-2), filagin A (FLNa) and migration-inducible protein-7 (MIG-7) in colon cancer and reveal their correlation with clinicopathological factors and prognosis of colon cancer. 【Methods】A total of 120 patients with colon cancer who underwent surgical resection in our hospital were enrolled in the study. The postoperative cancer tissues and adjacent tissues were taken to measure the expression of MMP-9, MMP-2, FLNa and MIG-7 in colon cancer by immunohistochemical examination. Meanwhile their relationship with clinical pathological factors and prognosis were analyzed as well. 【Results】 The positive rates of MMP-9, MMP-2 and MIG-7 in cancer tissues were higher than those in adjacent tissues,while the positive rate of FLNa in cancer tissues was lower than that in adjacent tissues (P<0.05). The lymph node metastasis rate, phase Ⅲ ratio, vascular infiltration rate, and middle and low differentiation rate of MMP-9, MMP-2, and MIG-7 positive patients were higher than those with negative expression patients(P<0.05), however, the lymph node metastasis rate, phase Ⅲ ratio, vascular infiltration rate, and middle and low differentiation rate of FLNa positive patients were lower than those with negative expression patients (P<0.05). The median follow-up time was 26 months and 22 patients died. COX multivariate analysis showed that TNM stage, FLNa, MIG-7, MMP-2, MMP-9, tumor differentiation, and lymph node metastasis were independent factors of survival (P<0.05). 【Conclusion】MMP-9, MMP-2 and MIG-7 are highly expressed in colon cancer tissues, and FLNa is lowly expressed in colon cancer tissues. The expressions of FLNa, MIG-7, MMP-2 and MMP-9 are associated with tumor invasion and prognosis.

Key words： Colonic Neoplasms/PA Matrix Metalloproteinase 9/BL Matrix Metalloproteinase 2/BL

收稿日期: 2019-07-28

PACS:

R735.35

通讯作者: E-mail:15829016861@163.com

引用本文:

杨华, 侯静芳. MMP-9、MMP-2、MIG-7、FLNa在结肠癌中的表达及意义[J]. 医学临床研究, 2020, 37(6): 866-869.
YANG Hua, HOU Jing-fang. Expression and Significance of MMP-9, MMP-2, MIG-7 and FLNa in Colon Cancer. JOURNAL OF CLINICAL RESEARCH, 2020, 37(6): 866-869.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.06.020 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I6/866

[1] Owen Dyer,杨广建.结直肠癌:鉴于年轻成年人群发病率不断攀升,美国指南敦促从45岁开始进行筛查[J].中华外科杂志,2019,57(3):199.
[2] Vinnakota K, Zhang Y, Selvanesan B C, et al. M2-like macrophages induce colon cancer cell invasion via matrix metalloproteinases[J].J Cell Physiol,2017,232(12):3468-3480.
[3] 李明玉,贾喜花.结肠癌组织血管生成抑制素结合蛋白、迁移诱导蛋白-7、MMP-2表达及其与血管生成拟态的相关性[J].山东医药,2019,59(6):5-8.
[4] 周昱.结肠癌组织中基质金属蛋白酶9、转录因子1与细丝蛋白A的表达研究[J].中国现代医学杂志,2018,28(27):53-56.
[5] 李琨琨,吴慧丽.肝素酶抑制剂对结肠癌细胞侵袭迁移及MMP-2、MMP-9表达的影响[J].中国老年学杂志,2018,38(10):2454-2457.
[6] Wieczorek E, Jablonowski Z, Tomasik B, et al. MMP, VEGF and TIMP as prognostic factors in recurring bladder cancer[J].Clin Biochem,2015,48(18):1235-1240.
[7] Liu Y, Wang Y, Teng Z, et al.Matrix metalloproteinase 9 expression and survival of patients with osteosarcoma: a meta-analysis[J].Eur J Cancer Care (Engl),2017,26(1):45.
[8] Ramos EA, Silva CT, Manica GC, et al. Worse prognosis in breast cancer patients can be predicted by immunohistochemical analysis of positive MMP-2 and negative estrogen and progesterone receptors[J].Rev Assoc Med Bras (1992),2016,62(8):774-781.
[9] Jia H, Zhang Q, Liu F, et al. Prognostic value of MMP-2 for patients with ovarian epithelial carcinoma: a systematic review and meta-analysis[J].Arch Gynecol Obstet,2017,295(3):689-696.
[10] Xu B, Li KP, Shen F, et al. Ulinastatin reduces cancer recurrence after resection of hepatic metastases from colon cancer by inhibiting MMP-9 activation via the antifibrinolytic pathway[J].Biomed Res Int,2013,2013:437950.
[11] Hsu HH, Kuo WW, Day CH, et al. Taiwanin E inhibits cell migration in human LoVo colon cancer cells by suppressing MMP-2/9 expression via p38 MAPK pathway[J].Environ Toxicol,2017,32(8):2021-2031.
[12] Lin S, Jiang T, Yu Y, et al. Secernin-1 contributes to colon cancer progression through enhancing matrix metalloproteinase-2/9 exocytosis[J].Dis Markers,2015,2015:230703.
[13] Czekierdowski A, Czekierdowska S, Stachowicz N, et al. Mig-7 expression and vasculogenic mimicry in malignant ovarian tumors[J].Ginekol Pol,2017,88(10):552-561.
[14] Sun GG, Lu YF, Zhang J, et al. Filamin A regulates MMP-9 expression and suppresses prostate cancer cell migration and invasion[J].Tumour Biol,2014,35(4):3819-3826.