医学临床研究
  2025年4月4日 星期五           首 页    |    期刊简介    |    编委会    |    投稿指南    |    期刊订阅    |    广告合作    |    留言板    |    联系我们    |    English
医学临床研究  2020, Vol. 37 Issue (6): 866-869    DOI: 10.3969/j.issn.1671-7171.2020.06.020
  论著 本期目录 | 过刊浏览 | 高级检索 |
MMP-9、MMP-2、MIG-7、FLNa在结肠癌中的表达及意义
杨华, 侯静芳
陕西省西安市第一医院 肿瘤科,陕西 西安 710002
Expression and Significance of MMP-9, MMP-2, MIG-7 and FLNa in Colon Cancer
YANG Hua, HOU Jing-fang
Xi'an No. 1 Hospital oncology department Xi 'an, Shaanxi 710002
全文: PDF (0 KB)   HTML (1 KB) 
输出: BibTeX | EndNote (RIS)      
摘要 目的】 观察基质金属蛋白酶9(MMP-9)、基质金属蛋白酶2(MMP-2)、细丝蛋白A(FLNa)、迁移诱导蛋白-7(MIG-7)在结肠癌中的表达情况,并分析其与结肠癌临床病理因素、预后的相关性。【方法】 在本院接受手术切除的120例结肠癌患者,取其术后癌组织及癌旁组织检测(免疫组化法)MMP-9、MMP-2、FLNa、MIG-7的表达情况,分析其与患者临床病理因素、预后的关系。【结果】 癌组织MMP-9、MMP-2、MIG-7阳性率较癌旁组织高,FLNa阳性率较癌旁组织低,且差异均有显著性(P<0.05)。MMP-9、MMP-2、MIG-7表达阳性患者淋巴结转移率、TNM Ⅲ期比例、脉管浸润率、中低分化比例高于表达阴性患者(P<0.05),FLNa表达阳性患者淋巴结转移率、Ⅲ期比例、脉管浸润率、中低分化比例低于表达阴性患者(P<0.05)。中位随访时间26个月,死亡22例。COX多因素分析结果显示,TNM分期、FLNa、MIG-7、MMP-2、MMP-9、肿瘤分化程度、淋巴结转移是生存率独立影响因素。【结论】 结肠癌组织中MMP-9、MMP-2、MIG-7高表达,FLNa低表达。FLNa、MIG-7、MMP-2、MMP-9表达与肿瘤浸润及预后相关。
服务
把本文推荐给朋友
加入我的书架
加入引用管理器
E-mail Alert
RSS
作者相关文章
杨华
侯静芳
关键词 结肠肿瘤/病理学基质金属蛋白酶9/血液基质金属蛋白酶2/血液    
Abstract:【Objective】To investigate the expression of matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase 2 (MMP-2), filagin A (FLNa) and migration-inducible protein-7 (MIG-7) in colon cancer and reveal their correlation with clinicopathological factors and prognosis of colon cancer. 【Methods】A total of 120 patients with colon cancer who underwent surgical resection in our hospital were enrolled in the study. The postoperative cancer tissues and adjacent tissues were taken to measure the expression of MMP-9, MMP-2, FLNa and MIG-7 in colon cancer by immunohistochemical examination. Meanwhile their relationship with clinical pathological factors and prognosis were analyzed as well. 【Results】 The positive rates of MMP-9, MMP-2 and MIG-7 in cancer tissues were higher than those in adjacent tissues,while the positive rate of FLNa in cancer tissues was lower than that in adjacent tissues (P<0.05). The lymph node metastasis rate, phase Ⅲ ratio, vascular infiltration rate, and middle and low differentiation rate of MMP-9, MMP-2, and MIG-7 positive patients were higher than those with negative expression patients(P<0.05), however, the lymph node metastasis rate, phase Ⅲ ratio, vascular infiltration rate, and middle and low differentiation rate of FLNa positive patients were lower than those with negative expression patients (P<0.05). The median follow-up time was 26 months and 22 patients died. COX multivariate analysis showed that TNM stage, FLNa, MIG-7, MMP-2, MMP-9, tumor differentiation, and lymph node metastasis were independent factors of survival (P<0.05). 【Conclusion】MMP-9, MMP-2 and MIG-7 are highly expressed in colon cancer tissues, and FLNa is lowly expressed in colon cancer tissues. The expressions of FLNa, MIG-7, MMP-2 and MMP-9 are associated with tumor invasion and prognosis.
Key wordsColonic Neoplasms/PA    Matrix Metalloproteinase 9/BL    Matrix Metalloproteinase 2/BL
收稿日期: 2019-07-28     
PACS:  R735.35  
通讯作者: E-mail:15829016861@163.com   
引用本文:   
杨华, 侯静芳. MMP-9、MMP-2、MIG-7、FLNa在结肠癌中的表达及意义[J]. 医学临床研究, 2020, 37(6): 866-869.
YANG Hua, HOU Jing-fang. Expression and Significance of MMP-9, MMP-2, MIG-7 and FLNa in Colon Cancer. JOURNAL OF CLINICAL RESEARCH, 2020, 37(6): 866-869.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.06.020     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I6/866
版权所有 © 2013 医学临床研究杂志社  湘ICP备13012052号-1
办公地址:湖南省长沙市芙蓉区新军路43号煤炭大院主办公楼6楼621、623、632、636室 邮编:410011 电话(传真):0731-84824007 E-mail:jcr_cs.hn@vip.163.com
技术支持:北京玛格泰克科技发展有限公司 技术支持:support@magtech.com.cn