Abstract：【Objective】 To investigate the changes of thyroid function and the occurrence of thyroid dysfunction during pregnancy with hypertensive disorder complicating pregnancy (HDCP). 【Methods】 A total of 120 pregnant women with hypertensive disorder complicating pregnancy were selected as the observation group, including 48 cases of pregnancy-induced hypertension, 40 cases of pre-eclampsia, and 32 cases of eclampsia. In the same time period,120 pregnant women with normal blood pressure, no internal and obstetric complications were selected as the control group. The levels of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free tetraiodothyronine (FT4), and thyroid peroxidase antibodies (TPOAb) in early pregnancy (first trimester <12 weeks), second trimester (12-28 weeks), and late pregnancy (third trimester >28 weeks) were detected and the occurrence of thyroid abnormalities during pregnancy were recorded. 【Results】 With the increase of pregnancy, the TSH level and TPOAb positive rate in the observation group gradually increased, while both FT3 and FT4 gradually decreased. In the first and second trimesters of pregnancy, the FT3 of the observation group was lower than that of the control group (P<0.05). In the second and third trimesters, the TSH of the observation group was higher than that of the control group (P<0.05), while the FT4 was lower than that of the control group (P<0.05). In the late pregnancy, the positive rate of TPOAb in the observation group was higher than that in the control group (P<0.05). The positive rate of TPOAb in the observation group was higher than that in the control group (P<0.05). The FT3 in the first and second trimester, FT4 in the second and third trimester in eclampsia pregnant women were lower than those in pregnancy-induced hypertension women (P<0.05). The positive rate of TPOAb in late pregnancy, TSH in mid-pregnancy and late pregnancy in eclampsia women were higher than those in pregnancy-induced hypertension women(P<0.05). The TSH of pregnant women with eclampsia was higher in the second and late trimester than those with preeclampsia (P<0.05). The cumulative incidence of subclinical hypothyroidism and the total incidence of thyroid dysfunction in the observation group were higher than those in the control group (P<0.05). The incidence of subclinical hypothyroidism and thyroid dysfunction in eclampsia women was higher than that in pre-eclampsia and pregnancy-induced hypertension pregnant women (P<0.05). The cumulative incidence of subclinical hypothyroidism was positively correlated with severity of eclampsia (P<0.05). 【Conclusion】 The incidence of thyroid dysfunction in pregnant women with hypertensive disorder complicating pregnancy is high, especially in pregnant women with eclampsia. The screening of thyroid function in these patients should be paid attention to in clinical practice.
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2020, Vol. 37 
