Abstract：【Objective】 To investigate the clinical effect of percutaneous coronary intervention (PCI) in the treatment of coronary heart disease (CHD) and its effect on serum vascular endothelial growth factor (VEGF).【Methods】 The clinical data of 92 patients with CHD admitted to our hospital from January 2017 to January 2019 were retrospectively analyzed, and they were divided into observation group and control group according to different treatment methods, with 46 cases in each group. The control group received conservative treatment, while the observation group received PCI on the basis of the control group. The treatment efficiency, cardiac function indexes (LVESD, LVEDD, LVEF, BNP), VEGF levels before and after treatment and the incidence of adverse cardiovascular events were compared between the two groups.【Results】 The effective rate of the observation group was 95.65% (44/46), which was significantly higher than 80.43% (37/46) of the control group (χ2=5.061,P=0.023<0.05). After treatment, LVESD, LVEDd and serum BNP levels in the two groups were lower than those before treatment, and LVEF was higher than that before treatment, and the differences between the two groups were statistically significant (P<0.05). Immediately after operation, the serum VEGF level of the observation group was higher than that of the control group, and the serum VEGF level of the observation group was lower than that of the control group 48 h and 1 week after treatment, the difference was statistically significant (P<0.05). After 3 months of follow-up, the incidence of adverse cardiovascular events in the observation group was 0, which was lower than 15.22% (7/46) of the control group (χ2=5.572,P=0.018<0.05).【Conclusion】 CHD patients with PCI treatment has a good clinical effect, and can reduce the level of VEGF, can better improve the cardiac function of patients, worthy of clinical reference.
刘许增, 余新东, 罗才福, 何显荣, 刘洋. 经皮冠状动脉介入治疗冠心病的临床效果及对患者血清VEGF水平的影响[J]. 医学临床研究, 2020, 37(7): 1042-1044.
LIU Xu-zeng, YU Xin-dong, LUO Cai-fu, et al. Clinical Effect of Percutaneous Coronary Intervention on Coronary Heart Disease and its Influence on Serum VEGF Level. JOURNAL OF CLINICAL RESEARCH, 2020, 37(7): 1042-1044.
2020, Vol. 37 
