医学临床研究
  2025年6月12日 星期四           首 页    |    期刊简介    |    编委会    |    投稿指南    |    期刊订阅    |    广告合作    |    留言板    |    联系我们    |    English
医学临床研究  2019, Vol. 36 Issue (1): 4-7    DOI: 10.3969/j.issn.1671-7171.2019.01.002
  论著 本期目录 | 过刊浏览 | 高级检索 |
复方丹参滴丸治疗糖尿病视网膜病变的临床研究
赵传巧
江苏省东海县中医院内科,江苏 连云港 222300
Clinical Effect of Compound Danshen(Salvia Miltiorrhiza) Pills in the Treatment of Diabetic Retinopathy
ZHAO Chuan-qiao
Department of Internal Medicine, the Chinese Medicine Hospital of Donghai County, Lianyungang,Jiangsu Province 222300
全文: PDF (0 KB)   HTML (1 KB) 
输出: BibTeX | EndNote (RIS)      
摘要 【目的】 探讨复方丹参滴丸治疗糖尿病视网膜病变(DR)的临床效果。【方法】 选取2015年3月至2017年10月本院收治的106例DR患者的临床资料,按随机数表法分为观察组和对照组,每组各53例。对照组患者予降糖、酸碱平衡等糖尿病常规治疗,观察组在对照组的基础上口服复方丹参滴丸治疗。观察两组患者的疗效,视野灰度、血管瘤体积、出血斑面积、黄斑厚度以及血清白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)、高敏C反应蛋白(hs-CRP)、血浆内皮素-1(ET-1)、血管内皮生长因子(VEGF)、活性氧(ROS),分光光度计法检测超氧化物歧化酶(SOD)和丙二醛(MDA)水平。【结果】 观察组总有效率为90.57%(48/53),显高于对照组的77.36%(41/53),差异有统计学意义(P<0.05)。两组患者的视野灰度及血管瘤体积、出血斑面积、黄斑厚度及血清hs-CRP、IL-6、TNF-α、ET-1、VEGF、ROS、MDA水平较治疗前均明显降低,SOD较治疗前明显升高,且观察组改善幅度较对照组更加显著,差异均有统计学意义(P<0.05)。治疗期间两组患者均未发生明显的药物不良反应。【结论】 复方丹参滴丸治疗DR可提高临床疗效,改善视野缺损症状,下调炎性指标,改善血管内皮功能,缓解氧化应激状态,且安全性良好,值得在临床中推广应用。
服务
把本文推荐给朋友
加入我的书架
加入引用管理器
E-mail Alert
RSS
作者相关文章
赵传巧
关键词 糖尿病视网膜病变/药物疗法药用制剂    
Abstract【Objective】 To investigate the clinical effect of compound salvia miltiorrhiza(Danshen) pills in the treatment of diabetic retinopathy(DR). 【Methods】 The clinical data of 106 patients with DR from March 2015 to October 2017 were divided into observation group and control group with 53 cases in each group. The patients in the control group were treated with hypoglycemic, acid-base balance, and the observation group was treated with compound salvia miltiorrhiza pills on the basis of the control group. The therapeutic effect, visual field grayscale, hemangioma volume, macular area, macular thickness, serum interleukin-6 (IL-6), tumor necrosis factor (TNF-α),high sensitivity C-reactive protein (hs-CRP), plasma endothelin-1 (ET-1), vascular endothelial growth factor (VEGF), reactive oxygen (ROS) were observed. The levels of superoxide dismutase (SOD) and malondialdehyde (MDA) (MDA) were measured by spectrophotometer.【Results】 The total effective rate was 90.57% (48 / 53) in the observation group and 77.36% (41/53) in the control group (P<0.05). The visual field grayscale, hemangioma volume, macular area, macular thickness, serum hs-CRP, IL-6,TNF-αand ET-1, VEGF, ROS, MDA levels were significantly lower in both groups than before treatment, and SOD was significantly higher than that before treatment. The improvement in the observation group was more significant than that in the control group, and the difference was statistically significant (P<0.05). There were no obvious adverse drug reactions in both groups during treatment.【Conclusion】 Compound salvia miltiorrhiza (Danshen) pills can improve the clinical efficacy, improve the symptoms of visual field defect, down-regulate the inflammatory index, improve vascular endothelial function, alleviate oxidative stress state, and the safety is good. It is worth popularizing in clinical application.
Key wordsDiabetic Retinopathy/DT    Pharmaceutical Preparations
收稿日期: 2018-09-13     
PACS:  R587.26  
引用本文:   
赵传巧. 复方丹参滴丸治疗糖尿病视网膜病变的临床研究[J]. 医学临床研究, 2019, 36(1): 4-7.
ZHAO Chuan-qiao. Clinical Effect of Compound Danshen(Salvia Miltiorrhiza) Pills in the Treatment of Diabetic Retinopathy. JOURNAL OF CLINICAL RESEARCH, 2019, 36(1): 4-7.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2019.01.002     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2019/V36/I1/4
版权所有 © 2013 医学临床研究杂志社  湘ICP备13012052号-1
办公地址:湖南省长沙市芙蓉区新军路43号煤炭大院主办公楼6楼621、623、632、636室 邮编:410011 电话(传真):0731-84824007 E-mail:jcr_cs.hn@vip.163.com
技术支持:北京玛格泰克科技发展有限公司 技术支持:support@magtech.com.cn