摘要【目的】分析立体定向放射治疗(SBRT)对早期非小细胞癌(NSCLC)患者的治疗效果和对肿瘤标记物及免疫功能的影响。【方法】选择2014年10月至2018年2月在本院诊断且符合纳入标准的66例早期NSCLC患者为研究对象,采用随机数字表法将其分为A组和B组,每组各33例。A组采用逆向调强放疗技术(IMRT)治疗,B组采用三维适形放疗技术(3D-CRT)治疗,比较两组的治疗效果和对肿瘤标记物血清糖类抗原125(CA125)、糖类抗原153(CA153)、癌胚抗原(CEA)及T淋巴细胞亚群CD3+、CD4+、CD4+/ CD8+指标水平的影响。【结果】A组的临床治疗总有效率明显高于B组(78.79% vs 54.55%,χ2=4.364,P<0.05);治疗后,两组血清CA125、CA153及CEA水平均明显低于治疗前(P<0.05),且A组明显低于B组(P<0.05);治疗后,两组血清CD3+、CD4+及CD4+/ CD8+水平均明显低于治疗前(P<0.05),且B组明显低于A组(P<0.05)。【结论】SBRT对早期NSCLC患者具有较好的治疗效果,其中IMRT的治疗效果优于3D-CRT,同时也能减轻对机体免疫功能的影响。
Abstract：【Objective】To analyze the effect of stereotactic body radiotherapy [SBRT: intensity-modulated radiation therapy (IMRT) and 3-D conformal radiotherapy (3D-CRT)] in patients with early non-small cell lung cancer (NSCLC) and its influence on tumor markers and immune function. 【Methods】A total of 66 patients with early NSCLC in our hospital were selected from Oct. 2014 to Feb. 2018 and were randomly divided into group A (n=33) and group B (n=33). Group A was treated with IMRT and group B was treated with 3D-CRT. The therapeutic effects of the two groups were compared. Also, effects on serum carbohydrate antigen 125 (CA125), carbohydrate antigen 153 (CA153), carcinoembryonic antigen (CEA) and T lymphocyte subsets CD3+, CD4+, CD4+/CD8+ index levels were compared. 【Results】 The total effective rate of group A (78.79%) was significantly higher than that of group B (78.79% vs 54.55%, χ2=4.364,P<0.05). After treatment, the serum levels of CA125, CA153 and CEA in the two groups were significantly lower than those before treatment (P<0.05),and those levels in group A were significantly lower than group B (P<0.05); After treatment, the serum levels of CD3+, CD4+, CD4+/CD8+ in the two groups were significantly lower than before treatment, and those levels in group B were significantly lower than group A (P<0.05). 【Conclusion】SBRT has good therapeutic effect on patients with early NSCLC. The effect of IMRT is better than that of 3D-CRT, and it can reduce the immune function of the body.
何栋成, 韩济华, 曹磊, 张艳, 张晓晔, 朱志坚. IMRT及3D-CRT对早期NSCLC患者的治疗效果和对肿瘤标记物及免疫功能的影响[J]. 医学临床研究, 2018, 35(11): 2107-2109.
HE Dong-cheng, HAN Ji-hua, CAO Lei,et al. Therapeutic Effect of IMRT and 3D-CRT in Patients with Early NSCLC and Its Influence on Tumor Markers and Immune Function. JOURNAL OF CLINICAL RESEARCH, 2018, 35(11): 2107-2109.
2018, Vol. 35 
