Abstract：【Objective】 To investigate the effect of Helicobacter pylori (HP) infection on proliferation, invasion and metastasis of hepatocellular carcinoma (HCC).【Methods】 Eighty liver cancer specimens from March 2015 to March 2017 and 80 normal liver specimens (> 5 cm from the edge of the cancer tissue) were selected as study samples. Each sample was divided into two parts, one was detected for HP immediately, the other was detected by immunohistochemistry for the expression of proliferation-related factor [B lymphocytoma 2 gene (Bcl-2), apoptosis suppressor gene (Survivin)] and invasion and metastasis related factor [transagglutinin (Transgelin),Integrinα2, cell adhesion factor (ICAM-1)], Matrix metalloproteinase 2 (MMP-2) and vascular endothelial growth factor (VEGF).【Results】 The positive rate of HP in HCC tissues was significantly higher than that in normal liver tissues, and the positive rate of proliferation, invasion and metastasis related factors in HCC tissues was significantly higher than that in normal liver tissues (P<0.05). The positive rates of Bcl-2 and Survivin were 92.73% and 94.55% in HP-infected liver cancer tissues, respectively, which were significantly higher than those in non-HP-infected liver cancer tissues (P<0.05); the positive rates of Transgelin, Integrin alpha 2, ICAM-1, MMP-2 and VEGF in HP-infected liver cancer tissues were 92.73%, 96.36%, 94.55%, 92.73% and 96.36%, respectively, which were significantly higher than those in non-HP-infected liver cancer tissues (P<0.05). 【Conclusion】 HP is involved in the occurrence and development of HCC, and can promote the proliferation, invasion and metastasis of HCC.
2019, Vol. 36 
