医学临床研究
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医学临床研究  2023, Vol. 40 Issue (12): 1875-1877    DOI: 10.3969/j.issn.1671-7171.2023.12.015
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2型糖尿病肾病患者血清NF-κB炎症信号通路与肾功能指标的相关性
陈景荷1, 贾鑫娜2*
1.陕西省宝鸡市人民医院重症医学科,陕西 宝鸡 721000;
2.蒲城县医院内分泌肾病科,陕西 渭南 715500
Correlation between Serum NF-κB Inflammatory Signaling Pathway and Renal Function Indicators in Patients with Type 2 Diabetic Nephropathy
CHEN Jinghe, JIA Xinna
Department of Critical Care Medicine, Baoji People's Hospital,Baoji Shaanxi 721000
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摘要 【目的】探讨2型糖尿病肾病(T2DN)患者血清核转录因子-κB(NF-κB)炎症信号通路与肾功能指标[血尿素氮(BUN)、血肌酐(Scr)、尿白蛋白排泄率(UAER)、β2-微球蛋白(β2-MG)、肾小球滤过率(eGFR)]的相关性。【方法】初诊的T2DN患者87例为A组,同期收治的单纯原发性2型糖尿病患者80例为B组,体检健康的志愿者70例为C组。比较三组临床资料,肾功能指标及血清NF-κB、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、高敏C反应蛋白(hs-CRP)水平。采用Pearson相关法分析T2DN患者血清NF-κB、TNF-α、IL-1β、hs-CRP、IL-6水平与肾功能指标的相关性。【结果】A组和B组空腹血糖、餐后2 h血糖高于C组(P<0.05);三组其他临床资料比较,差异无统计学意义(P>0.05)。A组BUN、Scr、UAER、β2-MG高于B组和C组(P<0.05),eGFR低于B组和C组(P<0.05);B组与C组上述指标比较,差异无统计学意义(P>0.05)。A组血清NF-κB、TNF-α、IL-1β、IL-6、hs-CRP水平高于B组和C组(P<0.05);B组上述指标均高于C组(P<0.05)。Pearson相关分析显示,T2DN患者血清NF-κB、TNF-α、IL-1β、IL-6、hs-CRP水平与BUN、Scr、UAER、β2-MG均呈正相关(P<0.05),与eGFR均呈负相关(P<0.05)。【结论】NF-κB炎症信号通路的激活介导了T2DN的发生、发展,且NF-κB、TNF-α、IL-1β、IL-6、hs-CRP均与肾功能指标存在明显相关性。
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陈景荷
贾鑫娜
关键词 糖尿病,2型/并发症糖尿病肾病NF-κB/血液信号传导肾功能试验    
Abstract:【Objective】To investigate the correlation between serum nuclear factor-kappa B (NF-κB) inflammatory signaling pathway and renal function indicators such as blood urea nitrogen (BUN), serum creatinine (Scr), urinary albumin excretion rate (UAER), β2-microglobulin (β2-MG), and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetic nephropathy (T2DN). 【Methods】Eighty-seven newly diagnosed T2DN patients (Group A), eighty patients with primary type 2 diabetes mellitus without nephropathy (Group B), and seventy healthy volunteers (Group C) were enrolled in the study. Clinical data, renal function indicators, and serum levels of NF-κB, tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β),interleukin-6(IL-6), and high-sensitivity C-reactive protein (hs-CRP) were compared among the three groups. Pearson correlation analysis was used to analyze the relationship of renal function indicators with serum levels of NF-κB, TNF-α, IL-1β, IL-6 and hs-CRP, in T2DN patients.【Results】Fasting blood glucose and 2-hour postprandial blood glucose in both group A and group B were higher than those in group C (P<0.05). Other clinical data showed no significant difference among the three groups (P>0.05). Levels of BUN, Scr, UAER, and β2-MG in group A were higher than those in groups B and C (P<0.05), while level of eGFR in group A was lower than that in groups of B and C (P<0.05). There were no significant differences in these above indicators between group B and group C (P>0.05). Serum levels of NF-κB, TNF-α, IL-1β, IL-6, and hs-CRP in group A were higher than those in Groups B and C (P<0.05); The above indicators of group B also were higher than those of group C (P<0.05). Pearson correlation analysis showed that serum levels of NF-κB, TNF-α, IL-1β, IL-6, and hs-CRP in T2DN patients were positively correlated with levels of BUN, Scr, UAER, and β2-MG (P<0.05), while they were negatively correlated with eGFR level (P<0.05). 【Conclusion】Activation of the NF-κB inflammatory signaling pathway mediates the pathogenesis of T2DN. NF-κB, TNF-α, IL-1β, IL-6 and hs-CRP are significantly correlated with renal function indicators.
Key wordsDiabetes Mellitus, Type 2/CO    Diabetic Nephropathies    NF-kappa B/BL    Signal Transduction    Kidney Function Tests
收稿日期: 2022-12-10     
中图分类号:  R587.1  
通讯作者: *E-mail:381343842@qq.com   
引用本文:   
陈景荷, 贾鑫娜. 2型糖尿病肾病患者血清NF-κB炎症信号通路与肾功能指标的相关性[J]. 医学临床研究, 2023, 40(12): 1875-1877.
CHEN Jinghe,JIA Xinna. Correlation between Serum NF-κB Inflammatory Signaling Pathway and Renal Function Indicators in Patients with Type 2 Diabetic Nephropathy. JOURNAL OF CLINICAL RESEARCH, 2023, 40(12): 1875-1877.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2023.12.015     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2023/V40/I12/1875
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