Abstract：【Objective】To investigate the correlation between serum nuclear factor-kappa B (NF-κB) inflammatory signaling pathway and renal function indicators such as blood urea nitrogen (BUN), serum creatinine (Scr), urinary albumin excretion rate (UAER), β2-microglobulin (β2-MG), and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetic nephropathy (T2DN). 【Methods】Eighty-seven newly diagnosed T2DN patients (Group A), eighty patients with primary type 2 diabetes mellitus without nephropathy (Group B), and seventy healthy volunteers (Group C) were enrolled in the study. Clinical data, renal function indicators, and serum levels of NF-κB, tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β),interleukin-6(IL-6), and high-sensitivity C-reactive protein (hs-CRP) were compared among the three groups. Pearson correlation analysis was used to analyze the relationship of renal function indicators with serum levels of NF-κB, TNF-α, IL-1β, IL-6 and hs-CRP, in T2DN patients.【Results】Fasting blood glucose and 2-hour postprandial blood glucose in both group A and group B were higher than those in group C (P<0.05). Other clinical data showed no significant difference among the three groups (P>0.05). Levels of BUN, Scr, UAER, and β2-MG in group A were higher than those in groups B and C (P<0.05), while level of eGFR in group A was lower than that in groups of B and C (P<0.05). There were no significant differences in these above indicators between group B and group C (P>0.05). Serum levels of NF-κB, TNF-α, IL-1β, IL-6, and hs-CRP in group A were higher than those in Groups B and C (P<0.05); The above indicators of group B also were higher than those of group C (P<0.05). Pearson correlation analysis showed that serum levels of NF-κB, TNF-α, IL-1β, IL-6, and hs-CRP in T2DN patients were positively correlated with levels of BUN, Scr, UAER, and β2-MG (P<0.05), while they were negatively correlated with eGFR level (P<0.05). 【Conclusion】Activation of the NF-κB inflammatory signaling pathway mediates the pathogenesis of T2DN. NF-κB, TNF-α, IL-1β, IL-6 and hs-CRP are significantly correlated with renal function indicators.
陈景荷, 贾鑫娜. 2型糖尿病肾病患者血清NF-κB炎症信号通路与肾功能指标的相关性[J]. 医学临床研究, 2023, 40(12): 1875-1877.
CHEN Jinghe,JIA Xinna. Correlation between Serum NF-κB Inflammatory Signaling Pathway and Renal Function Indicators in Patients with Type 2 Diabetic Nephropathy. JOURNAL OF CLINICAL RESEARCH, 2023, 40(12): 1875-1877.
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2023, Vol. 40 
