Abstract：【Objective】To investigate the protective effects of Shenmai injection on inflammatory factors and renal function in patients with septic acute kidney injury (AKI). 【Methods】A total of 120 patients with septic AKI were randomly divided into the control group (n=60) and the observation group (n=60). The control group was given routine treatment. While the observation group was treated with shenmai injection on the basis of control group. Both groupswere treated continuously for 7 days. Acute physiology and chronic health evaluation system Ⅱ (APACHEⅡ), serum creatinine (Scr), cystatin C (cys C), heparin binding protein (HBP), tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) levels were compared between two groups before treatment and on 3 d and 7 d after treatment. The duration of mechanical vasoactive drug(noradrenaline)and ventilation was compared between the two groups as well. 【Results】 Before treatment, there were no significant differences in the levels of Scr, cys C, HBP, TNF-α, IL-6 and APACHEⅡ scores between two groups (P<0.05). On day 3 and day 7 after treatment, all the above indexes decreased compared to those before treatment; And on day 7, the indexes decreased more significantly in the observation group than those in the control group (P<0.05). The days of ventilator and vasoactive drug used in the observation group were significantly lower than those in the control group (P<0.05). 【Conclusion】 Shenmai injection may play a protective role in patients with septic AKI by regulating inflammatory mediators.
孙良, 徐林, 王彩霞, 万甜甜. 参麦注射液对脓毒症急性肾损伤患者炎症因子表达水平和肾功能的影响[J]. 医学临床研究, 2023, 40(7): 1054-1056.
SUN Liang, XU Lin, WANG Cai-xia, et al. Effect of Shenmai Injection on Inflammatory Factors and Renal Function of Septic Acute Kidney Injury. JOURNAL OF CLINICAL RESEARCH, 2023, 40(7): 1054-1056.
[1] ZHANG T, XIANG L. Honokiol alleviates sepsis-induced acute kidney injury in mice by targeting the miR-218-5p/heme oxygenase-1 signaling pathway[J].Cell Mol Biol Lett,2019, 24(1):15. [2] MANRIQUE-CABALLERO C L, DEL RIO-PERTUZ G, GOMEZ H. Sepsis-associated acute kidney injury[J].Crit Care Clin,2021, 37(2):279-301. [3] BELLOMO R, KELLUM J A, RONCO C, et al.Acute kidney injury in sepsis[J].Intensive Care Med,2017, 43(6):816-828. [4] ZHANG F H, LIU Y, DONG X B, et al. Shenmai injection upregulates heme oxygenase-1 to confer protection against severe acute pancreatitis [J].J Surg Res,2020, 256(4):295-302. [5] 中华医学会重症医学分会. 中国严重脓毒症/脓毒性休克治疗指南(2014) [J].中华内科杂志, 2015, 54(6):557-581. [6] KHWAJA A. KDIGO clinical practice guidelines for acutekidney injury[J].Nephron Clin Pract,2012, 120(4):c179-c184. [7] 覃淼, 林雅丽, 石俊丹, 等. 参麦注射液对脓毒症全身麻醉患者血清炎症因子及血气分析指标的影响[J].广西医学, 2019, 41(13):1634-1637. [8] ZHOU Q, SUN Y, TAN W, et al. Effect of Shenmai injection on preventing the development of nitroglycerin-induced tolerance in rats [J].PLoS One,2017, 12(4):176-178. [9] GOMEZ H, KELLUM J A, RONCO C. Metabolic reprogramming and tolerance during sepsis-induced AKI [J].Nat Rev Nephrol,2017, 13(3):143-151. [10] BENTZER P, FISHER J, KONG H J, et al. Heparin-binding protein isimportant for vascular leak in sepsis[J].Intensive Care Med Exp,2016,4:33. [11] FISHER J, RUSSELL J A, BENTZER P, et al. Heparin-binding protein (HBP):a causative marker and potential target for heoarin treatment of human sepsis-induced acute kidney injury[J].Shock,2017, 48(3):313-320. [12] TVERRING J, VAARA S T, FISHER J, et al. Heparin-binding protein (HBP) improves prediction of sepsis-related acute kidney injury [J].Ann Intensive Care,2017, 7(1):105. [13] TYDEN J, HERWALD H, HULTIN M, et al. Heparin-binding protein as a biomarker of acute kidney injury in critical illness[J].Acta Anaesthesiol Scand,2017, 61(7):797-803.
2023, Vol. 40 
