Abstract：【Objective】To investigate the relationship of tissue type metal Protease inhibitor 4(TIMP-4),Free Fatty Acid (FFA) and thickness of epicardial adipose tissue (EAT) with cervical vascular disease in patients with type 2 diabetes Mellitus (T2DM) and coronary heart disease (CHD).【Methods】From May 2019 to May 2022,158 patients with T2DM and CHD who underwent coronary angiography in our hospital were selected and divided into two groups: non-cervical vascular disease group (n=90) and cervical vascular disease group (n=68). The clinical data of the two groups of patients were collected and compared between the two groups. The Serum Levels of Timp-4 and FFA were measured by Elisa,and the thickness of EAT was measured by echocardiography. Multivariate Logistic regression was used to analyze the risk factors of cervical vascular disease in T2DM patients with CHD. The diagnostic value of serum levels of TIMP-4,FFA and EAT thickness in patients with T2DM complicated with CHD cervical vascular disease was evaluated by ROC.【Results】Compared with the non-cervical vascular disease group,the serum level of TIMP-4 decreased (P<0.05),while the FFA level and the thickness of EAT increased (P<0.05). Multiple Logistic regression analysis showed that the decreased level of TIMP-4,the increased level of FFA and the thickness of EAT were the risk factors of cervical vascular disease in T2DM patients with CHD (OR=3.968,2.587,and 4.125,respectively,P<0.05). The AUC of serum TIMP-4,FFA and EAT thickness alone and the combination of the three detections in the diagnosis of cervical vascular disease in T2DM patients with CHD were 0.753,0.506,0.856 and 0.915,respectively,the sensitivity were 83.1%,70.69%,83.1% and 85.77%,respectively,the specificity was 85.60%,62.87%,89.6% and 82.96% respectively.【Conclusion】The combined detection of TIMP-4,FFA and EAT thickness in serum is valuable in the diagnosis of cervical vascular disease in patients of T2DM with CHD,which can provide reference for early diagnosis,prevention and treatment of cervical vascular disease in T2DM patients with CHD.
王博. 2型糖尿病合并冠心病患者TIMP-4、FFA水平和EAT厚度与颈部血管病变相关性分析[J]. 医学临床研究, 2023, 40(9): 1331-1334.
WANG Bo. Correlation of TIMP-4,FFA and EAT Thickness with Cervical Vascular Disease in Patients with Type 2 Diabetes Mellitus and Coronary Heart Disease. JOURNAL OF CLINICAL RESEARCH, 2023, 40(9): 1331-1334.
2023, Vol. 40 
