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医学临床研究  2022, Vol. 39 Issue (11): 1659-1661    DOI: 10.3969/j.issn.1671-7171.2022.11.017
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纤维蛋白原/白蛋白值、D-二聚体与急性心肌梗死患者冠脉病变程度的相关性分析
刘培1, 袁仕善2, 杨双1, 刘苗1*
1.湖南师范大学附属第一医院检验科,湖南 长沙 410005;
2.湖南师范大学医学院医学检验系,湖南 长沙 410005
Correlation between Fibrinogen/albumin Ratio, D-dimer and Severity of Coronary Artery Disease in Patients with Acute Myocardial Infarction
LIU Pei, YUAN Shi-shan, YANG Shuang, et al
Department of Clinical Laboratory,the First Affiliated Hospital in Hunan Normal University,Changsha Hunan 410005
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摘要 【目的】探讨纤维蛋白原/白蛋白值(FAR)、D-二聚体(DD)与急性心肌梗死(AMI)患者冠脉病变程度的相关性。【方法】选择2020年6月至2022年7月湖南师范大学附属第一医院收治的201例AMI患者(观察组),选择同期于湖南师范大学附属第一医院行冠脉造影检查的80例结果正常者(对照组)。采用多因素Logistic回归分析FAR、DD与AMI的相关性,根据累及病变支的数目及冠脉狭窄程度对AMI患者亚组FAR、DD进行分析,采用受试者工作曲线(ROC曲线)评估FAR、DD预测AMI及冠脉重度狭窄的效能。【结果】观察组患者FAR、DD均高于对照组,差异均有统计学意义(P<0.001)。多因素Logistic回归分析显示,FAR、DD是AMI发生的危险因素(P<0.05)。不同亚组结果显示:多支病变组FAR、DD均高于单支病变组,双支病变组DD高于单支病变组,差异均有统计学意义(P<0.05);重度狭窄组FAR、DD均高于轻度狭窄组,重度狭窄组DD高于中度狭窄组,差异均有统计学意义(P<0.05)。ROC曲线结果显示:FAR、DD预测AMI的ROC曲线下面积分别为0.721、0.71,敏感度分别为80.3%、87.3%;预测冠脉重度狭窄ROC曲线下面积分别为0.609、0.658,特异度分别为91.2%和91.2%。【结论】高水平FAR、DD与AMI发生存在相关性,且对AMI患者冠脉病变严重程度具有一定的诊断价值。
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刘培
袁仕善
杨双
刘苗
关键词 心肌梗死急性病纤维蛋白原白蛋白类纤维蛋白纤维蛋白原降解物    
Abstract:【Objective】To investigate the correlation between fibrinogen/albumin ratio (FAR), D-dimer (DD) and the severity of coronary artery disease in patients with acute myocardial infarction (AMI). 【Methods】A total of 201 patients with AMI admitted to our hospital from June 2020 to July 2022 (observation group) were selected, and 80 patients with normal results (control group) who underwent coronary angiography in our hospital at the same time were selected. Multivariate logistic regression was used to analyze the correlation between FAR, DD and AMI. FAR and DD in subgroups of AMI patients were analyzed according to the number of involved diseased branches and the degree of coronary stenosis. The efficacy of FAR and DD in predicting AMI and severe coronary stenosis was evaluated using the receiver operating characteristic (ROC) curve. 【Results】The FAR and DD of patients in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.001).Multivariate logistic regression analysis showed that FAR and DD were risk factors for AMI (P<0.05). The results of different subgroups showed that FAR and DD in the multi vessel disease group were higher than those in the single vessel disease group, and DD in double vessel disease group was higher than that in the single vessel disease group, with significant difference (P<0.05); FAR and DD in the severe stenosis group were higher than those in the mild stenosis group, and DD in the severe stenosis group was higher than that in the moderate stenosis group, with significant difference (P<0.05). The ROC curve results showed that the area under the ROC curve of FAR and DD to predict AMI was 0.721 and 0.71 respectively, and the sensitivity was 80.3% and 87.3% respectively; The area under the ROC curve for predicting severe coronary stenosis was 0.609 and 0.658, respectively, and the specificity was 91.2% and 91.2%, respectively. 【Conclusion】High level FAR and DD are correlated with AMI, and have certain diagnostic value for the severity of coronary artery disease.
Key wordsMyocardial Infarction    Acute Disease    Fibrinogen    Albumins    Fibrin Fibrinogen Degradation Products
收稿日期: 2022-08-01     
中图分类号:  R542.22  
通讯作者: *E-mail:1540499661@qq.com   
引用本文:   
刘培, 袁仕善, 杨双, 刘苗. 纤维蛋白原/白蛋白值、D-二聚体与急性心肌梗死患者冠脉病变程度的相关性分析[J]. 医学临床研究, 2022, 39(11): 1659-1661.
LIU Pei, YUAN Shi-shan, YANG Shuang, et al. Correlation between Fibrinogen/albumin Ratio, D-dimer and Severity of Coronary Artery Disease in Patients with Acute Myocardial Infarction. JOURNAL OF CLINICAL RESEARCH, 2022, 39(11): 1659-1661.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.11.017     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I11/1659
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