重症肺炎支原体肺炎患儿血清FIB、TSP-1水平及其与患儿预后的相关性

doi:10.3969/j.issn.1671-7171.2022.06.029

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摘要【目的】探讨重症肺炎支原体肺炎(MPP)患儿血清人纤维蛋白原(FIB)、血小板反应蛋白1(TSP-1)水平,并分析其与患儿预后相关性。【方法】选择佳县中医院收治的80例重症MPP患儿(重症组),另选取80例轻症MPP患儿作为轻症组,根据患儿病情转归情况将重症MPP患儿分为好转组(n=53)和恶化组(n=27)。采用酶联免疫吸附法检测各研究对象血清FIB、TSP-1水平,Pearson法分析FIB、TSP-1水平与肺炎严重指数(PSI)的相关性,受试者工作特征(ROC)曲线分析血清FIB、TSP-1对重症MPP患儿预后不良的预测价值。【结果】与轻症组MPP患儿比较,重症组MPP患儿血小板计数(PLT)、平均血小板体积(MPV)、D-二聚体、抗凝血酶Ⅲ(AT-Ⅲ)、白细胞计数(WBC)、中性粒细胞计数(Neu)、乳酸脱氢酶(LDH)、红细胞沉降率(ESR)、C反应蛋白(CRP)水平和PSI评分升高,差异有统计学意义(P<0.05)。重症组患儿血清FIB、TSP-1水平较轻症组患儿升高,差异有统计学意义(P<0.05)。重症MPP患儿血清FIB、TSP-1表达水平与PSI评分呈正相关性(P<0.05)。恶化组MPP组患儿血清FIB、TSP-1表达水平及PSI评分比轻症组MPP患儿显著升高,差异有统计学意义(P<0.05)。血清FIB、TSP-1联合预测重症MPP患儿预后不良敏感度为88.89%,特异度为81.13%,曲线下面积为0.920。【结论】重症MPP患儿血清FIB、TSP-1水平明显升高,与患儿疾病严重程度有关,可作为预测重症MPP患儿预后不良潜在的标志物。

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	高世悦
	曹亚敏

关键词 ：肺炎,支原体, 纤维蛋白原/血液, 凝血酶敏感蛋白 1/血液, 预后

Abstract：【Objective】To investigate the serum levels of human fibrinogen (FIB) and platelet reactive protein-1 (TSP-1) in children with severe Mycoplasma pneumoniae pneumonia (MPP),and to analyze their correlation with prognosis. 【Methods】 A total of 80 children with severe MPP (severe group) and 80 children with mild MPP were selected as the mild group. According to the prognosis of the children,the children with severe MPP were divided into the improvement group (n=53) and the deterioration group (n=27). The levels of FIB and TSP-1 in serum were detected by enzyme-linked immunosorbent assay. The correlation between FIB and TSP-1 levels and pneumonia severity index (PSI) was analyzed by Pearson method. The predictive value of FIB and TSP-1 in serum for the poor prognosis of children with severe MPP was analyzed by ROC curve.【Results】Compared with the mild MPP group,the platelet count (PLT),mean platelet volume (MPV),D-dimer,antithrombin Ⅲ (AT-Ⅲ),white blood cell count (WBC),neutrophil count (NEU),lactate dehydrogenase (LDH),erythrocyte sedimentation rate (ESR),C-reactive protein (CRP) and PSI score in the severe MPP group were significantly higher (P<0.05). The levels of serum FIB and TSP-1 in the severe group were significantly higher than those in the mild group (P<0.05). The expression levels of FIB and TSP-1 in serum of children with severe MPP were positively correlated with PSI score (P<0.05). The expression levels of FIB,TSP-1 and PSI score in the MPP group and the deterioration group were significantly higher than those in the mild MPP group (P<0.05). The sensitivity,specificity and area under the curve were 88.89%,81.13% and 0.920 respectively.【Conclusion】The levels of serum FIB and TSP-1 in children with severe MPP are significantly increased,which is related to the severity of the disease,and may be used as a potential marker to predict the poor prognosis of children with severe MPP.

Key words： Pneumonia, Mycoplasma Fibrinogen/BL Thrombospondin 1/BL Prognosis

收稿日期: 2021-12-22

中图分类号:

R725.631

通讯作者: *E-mail:m18992287056@163.com

引用本文:

高世悦, 曹亚敏. 重症肺炎支原体肺炎患儿血清FIB、TSP-1水平及其与患儿预后的相关性[J]. 医学临床研究, 2022, 39(6): 909-912.
GAO Shi-yue, CAO Ya-min. Serum FIB,TSP-1 Levels in Children with Severe Mycoplasma Pneumonia and their Correlation with Prognosis. JOURNAL OF CLINICAL RESEARCH, 2022, 39(6): 909-912.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.06.029 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I6/909

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