Abstract：【Objective】To investigate the serum levels of human fibrinogen (FIB) and platelet reactive protein-1 (TSP-1) in children with severe Mycoplasma pneumoniae pneumonia (MPP),and to analyze their correlation with prognosis. 【Methods】 A total of 80 children with severe MPP (severe group) and 80 children with mild MPP were selected as the mild group. According to the prognosis of the children,the children with severe MPP were divided into the improvement group (n=53) and the deterioration group (n=27). The levels of FIB and TSP-1 in serum were detected by enzyme-linked immunosorbent assay. The correlation between FIB and TSP-1 levels and pneumonia severity index (PSI) was analyzed by Pearson method. The predictive value of FIB and TSP-1 in serum for the poor prognosis of children with severe MPP was analyzed by ROC curve.【Results】Compared with the mild MPP group,the platelet count (PLT),mean platelet volume (MPV),D-dimer,antithrombin Ⅲ (AT-Ⅲ),white blood cell count (WBC),neutrophil count (NEU),lactate dehydrogenase (LDH),erythrocyte sedimentation rate (ESR),C-reactive protein (CRP) and PSI score in the severe MPP group were significantly higher (P<0.05). The levels of serum FIB and TSP-1 in the severe group were significantly higher than those in the mild group (P<0.05). The expression levels of FIB and TSP-1 in serum of children with severe MPP were positively correlated with PSI score (P<0.05). The expression levels of FIB,TSP-1 and PSI score in the MPP group and the deterioration group were significantly higher than those in the mild MPP group (P<0.05). The sensitivity,specificity and area under the curve were 88.89%,81.13% and 0.920 respectively.【Conclusion】The levels of serum FIB and TSP-1 in children with severe MPP are significantly increased,which is related to the severity of the disease,and may be used as a potential marker to predict the poor prognosis of children with severe MPP.
高世悦, 曹亚敏. 重症肺炎支原体肺炎患儿血清FIB、TSP-1水平及其与患儿预后的相关性[J]. 医学临床研究, 2022, 39(6): 909-912.
GAO Shi-yue, CAO Ya-min. Serum FIB,TSP-1 Levels in Children with Severe Mycoplasma Pneumonia and their Correlation with Prognosis. JOURNAL OF CLINICAL RESEARCH, 2022, 39(6): 909-912.
2022, Vol. 39 
