Abstract：【Objective】 To investigate the levels of serum adiponectin (APN), albumin (ALB) and laminin (LN) in patients with coronary heart disease (CHD) and their clinical significance. 【Methods】 A total of 117 patients with CHD (observation group) admitted to the No.986 Hospital of the Air Force of the Chinese People's Liberation Army Air Force from March 2018 to April 2020 were selected, and 89 healthy volunteers (control group) who underwent physical examination in the same period were selected. 117 patients with CHD were divided into mild disease group (43 cases), moderate disease group (38 cases) and severe disease group (36 cases) according to Gensini score. Enzyme linked immunosorbent assay (ELISA) was used to detect the levels of serum APN, ALB, LN. Pearson correlation analysis was used to analyze the correlation between the levels of serum APN, ALB, LN and Gensini score in patients with CHD. 【Results】Compared with the control group, the levels of serum APN and ALB in the observation group decreased significantly, and the level of serum LN increased significantly (P<0.05). The levels of serum APN and ALB from high to low were mild, moderate and severe lesion groups, and the levels of serum LN from high to low were severe, moderate and mild. The difference between the groups was statistically significant (P<0.05). The Gensini score of CHD patients was (43.64±13.76), the levels of serum APN and ALB were negatively correlated with Gensini score, and the level of LN was positively correlated with Gensini score (P<0.05). 【Conclusion】The low expression of APN and ALB and high expression of LN in serum of CHD patients may be related to the severity of CHD.
王海强, 王磊. 冠心病患者血清脂联素、白蛋白、层粘蛋白水平及其临床意义[J]. 医学临床研究, 2022, 39(7): 999-1001.
WANG Hai-qiang, WANG Lei. Serum Adiponectin, Albumin and Laminin Levels in Patients with Coronary Heart Disease and their Clinical Significance. JOURNAL OF CLINICAL RESEARCH, 2022, 39(7): 999-1001.
2022, Vol. 39 
