Comparison of the Effects of Sodium Lactate Ringer's Solution, Sodium Bicarbonate Ringer's Solution, and Sodium Acetate Ringer's Solution in Fluid Resuscitation due to Trauma Hemorrhagic Shock
HUO Yanwei, FAN Xiaoqiang
Department of Emergency,Norinco General Hospital, Xi'an Shaanxi 710065
Abstract：【Objective】 To compare the effects of sodium lactate Ringer's solution, sodium bicarbonate Ringer's solution, and sodium acetate Ringer's solution in fluid resuscitation caused by trauma hemorrhagic shock (THS).【Methods】 A total of 306 patients with multiple organ or tissue injuries undergoing fluid resuscitation caused by THS were randomly divided into three groups: Group A, Group B, and Group C, with 102 patients in each group. Group A was resuscitated with sodium lactate Ringer's solution, Group B with sodium bicarbonate Ringer's solution, and Group C with sodium acetate Ringer's solution. Blood serum inflammatory factors, blood gas indicators, coagulation function levels, incidence of complications, and in-hospital mortality rates were compared among three groups before and after resuscitation.【Results】 After resuscitation, levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in all three groups were elevated compared to pre-resuscitation levels, with the greatest change in Group A, followed by Group B, and then Group C (all P<0.05). Arterial blood lactate (Lac) levels were reduced, and arterial blood pH levels increased after resuscitation in all three groups, with the most significant improvement in Group B, followed by Group C then Group A (all P<0.05). Oxygen partial pressure (PaO2) and oxygen saturation (SaO2) increased after resuscitation in all three groups, but the differences among groups were not statistically significant (all P>0.05). After resuscitation, activated partial thromboplastin time (APTT) and prothrombin time (PT) levels were elevated in all groups, with the smallest increase in Group C, followed by Group B and Group A (P<0.05). The incidence of multiple organ dysfunction syndrome and in-hospital mortality rates in Group B and Group C were lower than that in Group A (P<0.05), while there were no significant differences between Group B and Group C (P>0.05).【Conclusion】 Sodium acetate Ringer's solution and sodium bicarbonate Ringer's solution were generally more effective than sodium lactate Ringer's solution in fluid resuscitation, with sodium acetate Ringer's solution showing the best ability to suppress the inflammatory response and maintain coagulation function, followed by sodium bicarbonate Ringer's solution. For patients at risk of liver or kidney dysfunction, sodium lactate Ringer's solution should be used cautiously.
霍延伟, 范小强. 乳酸钠林格液、碳酸氢钠林格液及醋酸钠林格液在创伤失血性休克液体复苏中的效果比较[J]. 医学临床研究, 2024, 41(12): 1878-1881.
HUO Yanwei, FAN Xiaoqiang. Comparison of the Effects of Sodium Lactate Ringer's Solution, Sodium Bicarbonate Ringer's Solution, and Sodium Acetate Ringer's Solution in Fluid Resuscitation due to Trauma Hemorrhagic Shock. JOURNAL OF CLINICAL RESEARCH, 2024, 41(12): 1878-1881.
2024, Vol. 41 
