Abstract:【Objective】To explore the effect of cardiopulmonary resuscitation (CPR) between abdominal pressure lifting device and hands-only chest compressions on prehospital cardiopulmonary resuscitation.【Methods】A total of 80 patients with cardiopulmonary resuscitation who were treated with cardiac arrest from January 2017 to 2020 were selected. According to the different methods of cardiopulmonary resuscitation before sending to hospital, they were divided into the hands-only CPR group (A group) and the CPR group with abdominal pressure lifting device (B group), with 40 cases in each group. The effects of cardiopulmonary resuscitation in the two groups were analyzed and compared. 【Results】The mean arterial pressure, heart rate, arterial PcO2 and end-expiratory PcO2 in the B group were significantly higher than those in the A group (P<0.05). The pulmonary oxygen partial pressure and blood lactic acid in the B group were significantly lower than those in the A group (P<0.05). After treatment, the time from cardiac arrest to spontaneous respiration in the B group was significantly shorter than that in the A group, and the CPR success rate, spontaneous circulation recovery rate, 24-hour survival rate and survival discharge rate of the B group were significantly higher than those of the A group (P<0.05). 【Conclusion】Compared to hands-only CPR with chest compressions, CPR with abdominal pressure lifting device is more beneficial to increase pulmonary ventilation, better hemodynamic effect, better recovery rate of spontaneous circulation and success rate of CPR, and better prognosis.