医学临床研究
  2025年4月6日 星期日           首 页    |    期刊简介    |    编委会    |    投稿指南    |    期刊订阅    |    广告合作    |    留言板    |    联系我们    |    English
医学临床研究  2021, Vol. 38 Issue (7): 966-970    DOI: 10.3969/j.issn.1671-7171.2021.07.002
  论著 本期目录 | 过刊浏览 | 高级检索 |
肺鳞状细胞癌组织热休克蛋白90的表达及其临床意义
唐耀香1, 罗佳娣1, 冯娟2, 臧洪婧1, 范松青1, 文秋元1**
1.中南大学湘雅二医院病理科,湖南 长沙 410011;
2.湖南省职业病防治院检验科,湖南 长沙 410007
Clinical Significance of Heat Shock Protein 90 Expression in Patients with Lung Squamous Cell Carcinoma
TANG Yao-xiang, LUO Jia-di, FENG Juan,et al
Department of Pathology, Second Xiangya Hospital, Central South University, Changsha 410011
全文: PDF (1900 KB)   HTML (1 KB) 
输出: BibTeX | EndNote (RIS)      
摘要 【目的】探讨肺鳞状细胞癌组织中热休克蛋白90(HSP90)的表达,分析其表达与临床病理特征及预后的关系。【方法】选取2003~2013年在中南大学湘雅二医院胸外科手术切除的159例具有完整随访资料的肺鳞状细胞癌患者的癌组织和53例非癌对照肺组织的石蜡标本,制作高通量的组织芯片,采用免疫组织化学SP法检测组织样本中HSP90的表达,回顾性分析其表达水平与患者临床病理特征的关系;采用Kaplan-Meier生存曲线分析HSP90不同表达水平与肺鳞状细胞癌患者总生存时间(OS)的差异。【结果】与非癌肺组织相比,肺鳞状细胞癌组织中HSP90的高表达率明显增高(P<0.05);临床Ⅲ期患者的HSP90表达水平高于临床Ⅰ~Ⅱ期患者(P=0.010),淋巴结有癌转移的患者的HSP90的表达水平高于无淋巴结转移的患者(P=0.016),高表达HSP90的肺鳞状细胞癌患者总体生存率显著低于低表达HSP90的患者(P=0.002);Cox多因素风险回归分析发现,高表达HSP90的肺鳞状细胞癌患者预后比低表达HSP90患者差(P=0.042)。【结论】除临床分期及肿瘤的病理分级外,高表达HSP90可作为评估外科手术切除肺鳞状细胞癌患者预后差的独立分子标志物。
服务
把本文推荐给朋友
加入我的书架
加入引用管理器
E-mail Alert
RSS
作者相关文章
关键词 肺肿瘤/病理学鳞状细胞/病理学HSP90热休克蛋白质类分析    
Abstract:【Objective】To investigate the expression of heat shock protein 90(HSP90) in lung squamous cell carcinoma and analyze the relationship between its expression and clinicopathological characteristics and prognosis. 【Methods】 The cancer tissues of 159 lung squamous cell carcinoma(SCC) patients with complete follow-up data and 53 non-cancer control lung tissues(Non-CLT), who were selected from the thoracic surgery of the Second Xiangya Hospital of Central South University between 2003 and 2013, were retrospectively evaluated. High-throughput tissue microarray(TMA) were constructed and the expression of HSP90 were detected by immunohistochemistry(IHC). Kaplan-Meier univariate and Cox multivariate hazard regression analysis were performed to assess the prognosis of patients with lung SCC. 【Results】 Compared with Non-CLT, the positive expression rate of HSP90 in lung SCC tissue was significantly higher(P<0.05); and the expression level of HSP90 in clinical stage Ⅲ patients was higher than that in clinical stage Ⅰ-Ⅱ patients(P=0.010). The expression level of HSP90 in patients with lymph node metastasis was higher than that in patients without lymph node metastasis(P=0.016). The overall survival rate of patients with lung squamous cell carcinoma with high expression of HSP90 was significantly lower than that of patients with low expression of HSP90(P=0.002). Cox multivariate risk regression analysis found that patients with lung SCC with high expression of HSP90 had a worse prognosis than low expression of HSP90(P=0.042). 【Conclusion】 In addition to the clinical stage and pathological grade of the tumor, the high expression of HSP90 can be used as an independent molecular marker for evaluating the poor prognosis of patients with surgically removed lung SCC.
Key wordsLung Neoplasms/PA    Carcinoma, Squamous Cell/PA    HSP90 Heat-Shock Proteins/AN
收稿日期: 2021-05-17     
中图分类号:  R734.2  
基金资助:国家自然科学基金资助项目(No:81703009);中南大学中央高校基本科研业务费专项资金(2021zzts1045)
通讯作者: **E-mail:wenqiuyuan@csu.edu.cn   
引用本文:   
唐耀香, 罗佳娣, 冯娟, 臧洪婧, 范松青, 文秋元. 肺鳞状细胞癌组织热休克蛋白90的表达及其临床意义[J]. 医学临床研究, 2021, 38(7): 966-970.
TANG Yao-xiang, LUO Jia-di, FENG Juan,et al. Clinical Significance of Heat Shock Protein 90 Expression in Patients with Lung Squamous Cell Carcinoma. JOURNAL OF CLINICAL RESEARCH, 2021, 38(7): 966-970.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2021.07.002     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2021/V38/I7/966
版权所有 © 2013 医学临床研究杂志社  湘ICP备13012052号-1
办公地址:湖南省长沙市芙蓉区新军路43号煤炭大院主办公楼6楼621、623、632、636室 邮编:410011 电话(传真):0731-84824007 E-mail:jcr_cs.hn@vip.163.com
技术支持:北京玛格泰克科技发展有限公司 技术支持:support@magtech.com.cn