Abstract：【Objective】 To explore the correlation between coagulation indicators such as fibrin degradation products and the prognosis of patients with severe burn shock:the early warning value of fibrin degradation products (FDP) and coagulation indexes for the prognosis of patients with severe burn shock. 【Methods】 A total of 91 patients with severe burn shock admitted to our hospital were selected as the research objects. The basic information of all patients and coagulation indexes such as FDP at admission were collected. The patients were followed up for 60 days after treatment to calculate their survival. Factors affecting the prognosis of patients and value of coagulation indexes in predicting the prognosis of patients were analyzed.【Results】 During the follow-up period of 91 severe burn shock patients,33 cases died (36.26%,33/91 ),and the remaining 58 cases (63.74%,58/91) survived. Logistic regression analysis showed that acute physiology and chronic health status score Ⅱ(APACHE Ⅱ), total burn area,activation partial thromboplastin time (APTT),and FDP were independent factors affecting the prognosis of patients (P<0.05). The ROC curve results showed that the sensitivities of FDP,APTT and their combination to predict the prognosis of patients with severe burn shock were 72.72%,75.76% and 72.72%,respectively,while the specificities were 72.41%,70.69%,and 96.55%,respectively,and the AUC were 0.762,0.774,and 0.905,respectively. 【Conclusion】 Patients with severe burn shock are at higher risk of poor prognosis. FDP and APTT are related to the prognosis of patients with severe burn shock. The combination of the two has a good prognostic value in predicting the prognosis.
郭雪鹏, 尹明明, 王国辉, 周波, 李永强, 庹章强. 纤维蛋白降解产物等凝血指标与严重烧伤休克患者预后的相关性[J]. 医学临床研究, 2023, 40(3): 421-424.
GUO Xue-peng, YIN Ming-ming, WANG Guo-hui, et al. Correlation between Coagulation Indicators Such as Fibrin Degradation Products and the Prognosis of Patients with Severe Burn Shock. JOURNAL OF CLINICAL RESEARCH, 2023, 40(3): 421-424.
[1] PARTAIN K P,FABIA R,THAKKAR R K. Pediatric burn care:new techniques and outcomes[J].Curr Opin Pediatr,2020,32(3):405-410. [2] ADIBFAR A,CAMACHO F,ROGERS A D,et al. The use of vasopressors during acute burn resuscitation[J].Burns,2021,47(1):58-66. [3] WILLIAMS F N,LEE J O. Pediatric burn infection[J].Surg Infect (Larchmt),2021,22(1):54-57. [4] 卢蕾,王亚萍,黄璇,等. 血小板聚集率和凝血试验相关参数在危重烧伤患者中的变化及临床意义[J].临床与病理杂志,2019,39(12):2704-2709. [5] FENG J. Connexin 43 upregulation in burns promotes burn conversion through spread of apoptotic death signals[J].Burns,2020,46(6):1389-1397. [6] 中华医学会烧伤外科学分会,中国医师协会烧伤科医师分会.烧伤康复治疗指南(2013版)[J].中华烧伤杂志,2013,29(6):497-504. [7] PAN K,PANWER A,ROY U,et al. A comparison of the intracerebral hemorrhage score and the acute physiology and chronic health evaluation Ⅱ score for 30-day mortality prediction in spontaneous intracerebral hemorrhage[J].J Stroke Cerebrovasc Dis,2017,26(11):2563-2569. [8] AHTIALA M,SOPPI E,SAARI T I. Sequential organ failure assessment (SOFA) to predict pressure ulcer risk in intensive care patients:a retrospective cohort study[J].Ostomy Wound Manage,2018,64(10):32-38. [9] SAHLI S D,PEDRAZZI N,BRAUN J,et al. Effect of a factor-based coagulation management on blood product use after major burn injury:a retrospective cohort study[J].Burns,2021,47(7):1486-1494. [10] 马琪敏,刘晓彬,伍国胜,等. 特重度成年烧伤患者休克期凝血特征及其预警价值的回顾性队列研究[J].中华烧伤杂志,2021,37(2):150-156. [11] KAITA Y,NISHIMURA H,TANAKA Y,et al. Effect of acute coagulopathy before fluid administration in mortality for burned patients[J].Burns,2021,47(4):805-811. [12] 肖昆,赵斐,廖新成,等. 早期纠正凝血功能障碍降低大面积烧伤成年患者28 d病死率[J].中南大学学报(医学版),2021,46(8):851-857.
2023, Vol. 40 
