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Quick Search     Adv Search 2022 Vol. 39, No. 11 Published: 2022-11-26 Original Articles          Original Articles 1601 Clinical and Pathological Characteristics of Dermatopathic Lymphadenitis in Childhood LIU Ying, LUO Hai-yan, FAN Jiang-hua, et al DOI: 10.3969/j.issn.1671-7171.2022.11.001 【Objective】To investigate the clinical and pathological characteristics of dermatopathic lymphadenitis (DL) in childhood. 【Methods】 The clinical and pathological characteristics of 2 children with DL admitted in the difficult and complicated comprehensive ward of our hospital from March to June 2020 were analyzed retrospectively, and the literature was reviewed. 【Results】Repeated fever and lymphadenectasis were the first symptoms of 2 children with DL, and the effect of anti infection treatment was not good. Systemic rash occurred in the course of the disease after admission, and the main symptom was inguinal lymphadenectasis. The clinical manifestation of child 1 was similar to histiocytic necrotizing lymphadenitis, which was finally diagnosed as dermatopathic lymphadenitis by pathological examination. After hormone treatment, the child's temperature gradually stabilized and the rash gradually subsided. Child 2 was finally diagnosed as juvenile idiopathic arthritis with DL. After treatment with hormone and tropizumab, his temperature gradually became normal and his rash subsided. 【Conclusion】Two cases of children with lymphadenitis due to dermatosis were rare in China, and the first symptom was repeated fever, lymphadenopathy (mainly inguinal), followed by skin changes, and the pathological change was non-specific reactive hyperplasia of lymph nodes. 2022 Vol. 39 (11): 1601-1603 [Abstract] ( 102 ) HTML (1 KB)  PDF (2048 KB)  ( 56 ) 1604 Clinical Analysis of CRT Combined with β Receptor Blocker in the Treatment of Chronic Heart Failure and its Influence on the Cardiac Function of Patients ZHU Guo-xing, MA Wen-shuai DOI: 10.3969/j.issn.1671-7171.2022.11.002 【Objective】 To investigate the clinical efficacy of cardiac resynchronization therapy (CRT) combined with β receptor blockers in the treatment of chronic heart failure (CHF) and its influence on cardiac function. 【Methods】 The clinical data of 76 patients with CHF admitted to our hospital from July 2017 to February 2020 were analyzed retrospectively, and they were divided into the observation group (CRT combined β receptor blocker treatment, n=36) and control group (β receptor blocker treatment, n=40). The left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD) and left ventricular end systolic diameter (LVESD) were compared between the two groups before treatment and 1, 3 and 6 months after treatment.The levels of serum brain natriuretic peptide (BNP), cardiac troponin I (cTnI), C-reactive protein (CRP), inflammatory factors, tumor necrosis factor a (TNF-α) and interleukin-6 (IL-6) were compared, and the adverse reactions during treatment were recorded. 【Results】 After one month, three months and six months of treatment, LVEF in the observation group was higher than that before treatment, LVEDD and LVESD were lower than that before treatment (P<0.05); LVEF in the control group increased, LVEDD and LVESD decreased, but the difference was not statistically significant (P>0.05). After one month, three months and six months of treatment, the serum BNP, cTnI, CRP, TNF-α and IL-6 levels of patients in the observation group were lower than those before treatment, and those in the observation group were lower than those in the control group, with statistical significance (P<0.05); After 6 months of treatment, the levels of serum TNF-α and IL-6 in the control group were lower than those before treatment, and the difference was statistically significant (P<0.05). Both groups had symptoms of fatigue, limb cooling, bradycardia and gastrointestinal discomfort during treatment, but there was no significant difference between the two groups (P>0.05). 【Conclusion】 CRT combined with β receptor blocker can significantly improve the cardiac function of patients with chronic heart failure, reduce the level of inflammatory factors, and do not increase adverse reactions, which is worthy of clinical promotion. 2022 Vol. 39 (11): 1604-1607 [Abstract] ( 42 ) HTML (1 KB)  PDF (1162 KB)  ( 61 ) 1608 Clinical Value of Combined Detection of Serum Lp-PLA2 and cTnT in Predicting Occurrence of Perioperative MACE in Elderly Patients with Hip Fractures LIANG Li-zhuo, LU Bin DOI: 10.3969/j.issn.1671-7171.2022.11.003 【Objective】To investigate the value of combined detection of serum lipoprotein-associated phospholipese A2 (Lp-PLA2) and cardiac troponin T (cTnT) in predicting the occurrence of MACE (Major adverse cardiovascular events) in elderly patients with hip fractures during perioperative period. 【Methods】A total of 1,267 elderly patients with hip fractures who underwent surgical treatment in our hospital between January 2015 and June 2021 were selected for prospective analysis. All patients underwent internal fixation or artificial hip replacement within 2 to 5 d after admission. There were 84 patients who developed MACE within 30 days after surgery were included in the MACE group,while 127 patients who were randomly (by using the random number table method) selected from no MACE patients were considered as the control group. The general data,preoperative examination results,perioperative indicators and levels of serum Lp-PLA2 and cTnT were collected and compared between the two groups. Receiver operating characteristic (ROC) curve was drawn and the area under the curve (AUC) was calculated to analyze the predictive value of serum Lp-PLA2 and cTnT levels in predicting perioperative MACE. 【Results】The average age,proportion of coronary heart disease and complication with other diseases in the MACE group were significantly higher than those in control group (P<0.05). The levels of serum Lp-PLA2 and cTnT at 1 d,3 d and 7 d after surgery in the two groups significantly increased if compared to those at 1 d before surgery (P<0.05). In addition,the levels of serum Lp-PLA2 and cTnT in the MACE group at 1 d,3 d and 7 d after surgery were higher than those in control group (P<0.05). ROC curve analysis results showed that the AUC values of serum Lp-PLA2,cTnT and the combination of both detections at 1 d after surgery in predicting perioperative MACE in elderly patients with hip fractures were 0.665,0.703 and 0.755,respectively; The AUC values of serum Lp-PLA2,cTnT and combination of the two at 3 d after surgery were 0.765,0.792 and 0.853,and their AUC values at 7 d after surgery were 0.825,0.852 and 0.932,respectively. 【Conclusion】The levels of serum Lp-PLA2 and cTnT in elderly patients with hip fractures are significantly increased after surgery. The combined detection of the two has a good reference value for predicting the occurrence of perioperative MACE. 2022 Vol. 39 (11): 1608-1611 [Abstract] ( 42 ) HTML (1 KB)  PDF (1254 KB)  ( 31 ) 1612 Omen Syndrome:A Case Report and Review of Related Literature YUE Shu-zhen, LUO Yang-yang, LI Ke-yao, et al DOI: 10.3969/j.issn.1671-7171.2022.11.004 【Objective】 To investigate the etiology, pathogenesis, diagnostic criteria, differential diagnosis and treatment of Omenn syndrome. 【Methods】 A case of Omenn syndrome was reported and the related literature was reviewed. 【Results】 A girl aged 1 year and 2 months had recurrent cough and fever, repeated erythema and scaling all over her body. There was no special history and personal history. Her sister had a history of "autoimmune hemolysis" and died. The results of gene examination showed that RAG1 was homozygous and the therapeutic effect was poor. 【Conclusion】The prognosis of Omenn syndrome is poor, and it often dies of organ failure and severe infection. 2022 Vol. 39 (11): 1612-1614 [Abstract] ( 74 ) HTML (1 KB)  PDF (1983 KB)  ( 134 ) 1615 Effects of Dexmedetomidine on Analgesic Effect,Inflammatory Factors and T Lymphocyte Subsets in Patients undergoing TACE Operation for Primary Liver Cancer LI Jie, ZHANG Yu-he, LI Wei, et al DOI: 10.3969/j.issn.1671-7171.2022.11.005 【Objective】To investigate the effect of dexmedetomidine on the analgesic effect,inflammatory factors and T lymphocyte subsets of patients undergoing percutaneous transhepatic arterial chemoembolization (TACE) for primary liver cancer. 【Methods】A total of 72 patients with primary liver cancer who were to be treated with TACE were randomly divided into the control group (administration of hydromorphone hydrochloride + tropisetron + saline) and the observation group (administration of hydromorphone hydrochloride + tropisetron + dexmedetomidine),each group had 36 cases of patients.The levels of visual pain simulation score (VAS),inflammatory factors and T lymphocyte subsets were compared between the two groups.Adverse reactions in the two groups of patients during the perioperative period were compared as well. 【Results】There was no significant difference in VAS scores between the two groups of patients before operation (P>0.05).The VAS scores of the two groups of patients at 6 h,12 h and 24 h after surgery were higher than those before surgery (P<0.05).The VAS scores of the observation group at 6 h,12 h and 24 h after operation were lower than those of the control group (P<0.05).At 24 h after surgery,the levels of IFN-γ and TGF-β in the two groups decreased (P<0.05).The levels of IFN-γ and TGF-β at 24 h in the observation group were lower than those in the control group (P<0.05).Compared with preoperatively,serum CD3+,CD4+,CD8+,CD4+/CD8+ ratio all decreased (P<0.05).The CD3+,CD4+,and CD4+/CD8+ ratio of the observation group were higher than those of the control group at 24 h after the operation (P<0.05).There was no difference in the CD8+ levels of the two groups at 24 h after the operation.Statistical significance (P>0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups of patients (P>0.05). 【Conclusion】Dexmedetomidine has a better analgesic effect on patients undergoing TACE for primary liver cancer,which can regulate the level of inflammatory factors and improve the patient's immune function.It is safe and reliable. 2022 Vol. 39 (11): 1615-1617 [Abstract] ( 38 ) HTML (1 KB)  PDF (1195 KB)  ( 82 ) 1618 Value of CTP and Multiphase CTA in Evaluating Collateral Circulation in Patients with Ischemic Stroke WANG Xiao-hui, GAO Ren DOI: 10.3969/j.issn.1671-7171.2022.11.006 【Objective】To investigate the value of CT perfusion imaging (CTP) combined with multiphase CT angiography (MP-CTA) in evaluating collateral circulation in patients with ischemic stroke. 【Methods】A total of 153 patients with ischemic stroke were examined by digital subtraction angiography (DSA). According to the DSA results,patients were divided into the good group (n=101,with good collateral circulation) and the poor group (n=52,with poor collateral circulation). All patients were examined with CTP and MP-CTA. The perfusion parameters of infarcted core area and ischemic penumbra (rMTT,rCBV,rTTP,rCBF) were compared between the two groups,and the consistency of collateral circulation in ischemic stroke patients was evaluated by CTP combined with MP-CTA and DSA. 【Results】The rMTT,rCBV and rTTP in the infarct core area in the poor group were lower than those in the good group (P<0.05). There was no significant difference in rCBF between the good group and the poor group (P>0.05). There was no significant difference in rMTT,rCBV and rTTP of ischemic penumbra between the two groups (P>0.05). The rCBF of the poor group was lower than that of the good group (P<0.05). CTP combined with MP-CTA had good consistency with DSA in evaluating collateral circulation in patients with ischemic stroke (Kappa=0.823,P=0.000). 【Conclusion】CTP combined with MP-CTA can evaluate the level of collateral circulation in patients with ischemic stroke to a certain extent,which is helpful to formulate a targeted treatment plan in time. 2022 Vol. 39 (11): 1618-1621 [Abstract] ( 44 ) HTML (1 KB)  PDF (1154 KB)  ( 130 ) 1622 Expression of Periostin Protein in Esophageal Squamous Cell Carcinoma and Its Correlation with Clinical Pathological Characteristics LI Chao, XU Xiao-ling, LI Juan, et al DOI: 10.3969/j.issn.1671-7171.2022.11.007 【Objective】 To investigate the expression of Periostin protein in esophageal squamous cell carcinoma and its correlation with the pathological features of patients. 【Methods】 A total of esophageal squamous cell carcinoma tissues (observation group) resected surgically in our hospital were collected, and the corresponding normal esophageal tissues (more than 5 cm from the cancer tissues) adjacent to the cancer were used as the control group. Immunohistochemistry, semi quantitative RT-PCR and Western blot were used to detect the expression of Periostin protein in esophageal squamous cell carcinoma tissues and normal esophageal tissues adjacent to the cancer. Kaplan-Meier survival curve Cox proportional hazard regression model was used to analyze the expression of Periostin protein and its correlation with the prognosis of patients with esophageal squamous cell carcinoma. 【Results】 The high expression rate of Periostin protein in the observation group was 63.6% (75/118), which was significantly higher than that in the control group [27.1% (32/118)]. The difference was statistically significant(χ2=31.614,P<0.001).The value of Periostin mRNA in esophageal squamous cell carcinoma tissues was higher than that in normal esophageal tissues (P<0.05). The value of Periostin/β-actin in normal tissues adjacent to esophageal carcinoma was lower than that in esophageal squamous cell carcinoma (P<0.05). The TNM stage, differentiation degree and lymph node metastasis of esophageal squamous cell carcinoma patients with different Periostin expression levels were statistically significant (P<0.05). The survival rate of patients with low expression of Periostin was significantly higher than that of patients with high expression of Periostin (P<0.05). Logistic multivariate regression analysis showed that the high expression of Priostin was a risk factor affecting the overall survival of patients with esophageal squamous cell carcinoma (P<0.05). 【Conclusion】 The expression of Periostin in esophageal squamous cell carcinoma is related to histological type, TNM stage and lymph node metastasis, which is of great significance in predicting the prognosis of esophageal squamous cell carcinoma. 2022 Vol. 39 (11): 1622-1625 [Abstract] ( 32 ) HTML (1 KB)  PDF (1634 KB)  ( 56 ) 1626 Therapeutic effect and Mechanism of 2-indolinone Derivatives on BLM-induced Pulmonary Fibrosis in Mice JIANG Xing-wen, HAN Lin-xi DOI: 10.3969/j.issn.1671-7171.2022.11.008 【Objective】To explore the therapeutic effect and related mechanism of 2-indolinone derivative (PMID) on bleomycin (BLM)-induced pulmonary fibrosis in mice. 【Methods】Forty SPF grade, 3-week-old male SD mice were randomly divided into the control group, the model group and the PMID low and high dose groups, with 10 mice in each group. After the pulmonary fibrosis model was successfully induced by BLM in model group and PMID low and high dose groups, mice in PMID low and high dose groups were given 5 mg/kg and 20 mg/kg PMID solution by gavage (twice·d, with an interval of 6~8 h) for 28 days. While mice in the control group and the model group were given the same amount of normal saline at the same time. After drug intervention, the histopathological changes and pulmonary fibrosis of mice in each group were observed by hematoxylin eosin (HE) staining and collagen fiber (Masson) staining, then the pulmonary fibrosis scores of mice were compared. The mRNA level of collagen Ⅲ in mouse lung was measured by real-time fluorescence quantitative PCR; Phosphatidylinositol 3-kinase (PI3K), p-PI3K, protein kinase B (AKT), p-AKT and hypoxia inducible factor-1α( HIF-1α) protein level were detected by Western blot. 【Results】Compared to the control group, the pulmonary fibrosis score, Collagen Ⅲ mRNA level, p-PI3K / PI3K, p-AKT / AKT and HIF-1α were higher in the model group, low dose PMID group and high dose PMID groups (P<0.05). While the pulmonary fibrosis score, Collagen Ⅲ mRNA level, p-PI3K / PI3K, p-AKT / AKT and HIF-1α of mice in low and high dose PMID groups were lower than those in the model group (P<0.05).In addition, the above index levels in the high-dose group were lower than those in the low-dose group (P<0.05). 【Conclusion】PMID can improve BLM-induced pulmonary fibrosis in mice, which may be related to the inhibition of PI3K / AKT / HIF-1α pathway activation and inhibition of collagen deposition. 2022 Vol. 39 (11): 1626-1629 [Abstract] ( 36 ) HTML (1 KB)  PDF (2088 KB)  ( 55 ) 1630 Effects of Butylphthalide Injection Combined with Vinpocetine Injection on Cerebral Hemodynamics and Cognitive Function of Patients with Acute Cerebral Infarction ZHANG Dong-zi, CHEN Bin DOI: 10.3969/j.issn.1671-7171.2022.11.009 【Objective】To observe the effects and safety of butylphthalide combined with vinpocetine on cerebral hemodynamics and cognitive function in the treatment of acute cerebral infarction(ACI)patients. 【Methods】A total of 120 ACI patients in our hospital were randomly divided into two groups with 60 cases in each group.The control group was given vinpocetine,while the observation group was given butylphthalide on the basis of the control group.Both groups were treated for 14 d.The clinical efficacy,NIHSS score,MMSE score,cerebral hemodynamics [peak flow velocity (Vp),average flow velocity (Vm),cerebrovascular reserve (CVR)] and serum homocysteine (Hcy),6-keto-prostaglandin-F1A (6-K-PGF1a) and VEGF were compared between the two groups. 【Results】The total effective rate of the observation group was higher than that of the control group ( P<0.05).Compared to before treatment,the NIHSS score of the two groups decreased after treatment; And NIHSS score of the observation group was significantly lower than that of the control group.After treatment,the MMSE score of the two groups increased and MMSE of the observation group was significantly higher than that of the control group (P<0.05).Compared with before treatment,Vp,Vm and CVR of the two groups showed an increasing trend after treatment,and those values in the observation group was significantly higher than those in the control group (P<0.05).Compared with before treatment,the Hcy of the two groups decreased after treatment,and the decreasing of the observation group was significantly lower than that of the control group.After treatment,the levels of 6-k-PGF1a and VEGF increased,and the increasing of the observation group was significantly higher than that of the control group (P<0.05).The incidence of adverse reactions in two group was not significantly different (P>0.05). 【Conclusion】Butylphthalide injection combined with vinpocetine injection have significant efficacy in the treatment of ACI,which can significantly improve cerebral hemodynamics,reduce the levels of Hcy,and increase the levels of 6-k-PGF1a and VEGF to promote the recovery of neural function and cognitive function,without increasing adverse drug reactions. 2022 Vol. 39 (11): 1630-1633 [Abstract] ( 53 ) HTML (1 KB)  PDF (1162 KB)  ( 45 ) 1634 Analysis of Clinicopathological Characteristics and Related Risk Factors in Middle-aged and Elderly Patients with Breast Hyperplasia SHEN Gui-hu, HU Yong-xin DOI: 10.3969/j.issn.1671-7171.2022.11.010 【Objective】Objective To investigate the clinicopathological characteristics and related risk factors in middle-aged and elderly patients with breast hyperplasia. 【Methods】 The clinical data of 139 middle-aged and elderly patients with breast hyperplasia admitted to Ningshan County Hospital from April 2017 to April 2020 (observation group) were retrospectively analyzed, and the clinical data of 139 healthy female volunteers in the same period (control group) were selected. The basic data [age, body mass index (BMI), residential area, nationality, marital status, wearing time, tightness, sleeping time, nursing method, breast stopping method, eating habits] of the two groups after admission were collected. The pathological characteristics of patients with breast hyperplasia were analyzed. Logistic regression analysis was used to analyze the risk factors of breast hyperplasia in the middle-aged and elderly. 【Results】The pathological features of middle aged and elderly patients with hyperplasia of mammary glands were duct epithelial hyperplasia, cyst formation, lobular hyperplasia, apocrine metaplasia, fibroadenoma formation and atypical hyperplasia. The proportion of patients with age ≥ 65 years, BMI ≥ 25 kg/m2, wearing time of tattooed chest ≥ 8 h, wearing tight tattooed chest, sleeping time<5 h, non breast feeding and drug breast stopping in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). Logistic regression analysis showed that age ≥ 65 years, BMI ≥ 25 kg/m2, wearing time of tattooed chest ≥ 8 hours, wearing tight tattooed chest, sleeping time<5 hours, non breast feeding, and drug breast stopping were the risk factors for adenosis in the middle-aged and elderly (P<0.05). 【Conclusion】 The occurrence of mammary hyperplasia in middle-aged and elderly patients is affected by many factors, including age, BMI, wearing time of tattooed chest, tightness of tattooed chest, sleeping time, lactation mode, and breast stopping mode. Clinicians should pay attention to the above factors in the diagnosis and treatment of such patients. 2022 Vol. 39 (11): 1634-1636 [Abstract] ( 48 ) HTML (1 KB)  PDF (1133 KB)  ( 69 ) 1637 Clinical Characteristics of Hypertrophic Cardiomyopathy with Hypertension DENG Ting-zhi, OU Bai-qing, ZHU Tian-gang, et al DOI: 10.3969/j.issn.1671-7171.2022.11.011 【Objective】 To compare the clinical characteristics of hypertrophic cardiomyopathy (HCM) with hypertension (HTN) and HCM without HTN. 【Methods】 The clinical data of 170 patients with HCM admitted to the People's Hospital of Peking University from December 2012 to July 2015 were analyzed retrospectively. They were divided into HCM with HTN group (n=57) and HCM without HTN group (n=113) according to whether HTN was incorporated or not. The basic data, ultrasonic parameters and medication of the two groups were compared. 【Results】 The age, smoking history, diabetes, dyslipidemia, coronary heart disease and atrial fibrillation of HCM patients with HTN were significantly higher than those of the control group (P<0.05). Echocardiography showed that the diameter of ascending aorta in HCM with HTN group was significantly wider than that in HCM without HTN group (P<0.05). The drug use rates of HCM combined with HTN group ACEI/ARB,β receptor blockers, diuretics, calcium antagonists, aspirin/clopidogrel, statins and nitrates were significantly higher than those of HCM without HTN (P<0.05). 【Conclusion】HCM and HTN can coexist at the same time. HCM patients with HTN have a significantly higher risk of diabetes, hyperlipidemia, coronary heart disease, and atrial fibrillation. 2022 Vol. 39 (11): 1637-1639 [Abstract] ( 36 ) HTML (1 KB)  PDF (1196 KB)  ( 24 ) 1640 Effect of Low SAPB Combined with General Anesthesia on Serum CRP,IL-6 and PCT Levels in Elderly Patients undergoing Upper Abdominal Surgery LI Zheng-wei, DENG Zhi-xi DOI: 10.3969/j.issn.1671-7171.2022.11.012 【Objective】To investigate the effects of serratus anterior plane block (SAPB) combined with general anesthesia on serum C-reactive protein (CRP),interleukin-6 (IL-6) and procalcitonin (PCT) levels in elderly patients undergoing upper abdominal surgery. 【Methods】A total of 78 elderly patients who were selected for upper abdominal surgery were randomly divided into the observation group and the control group.The patients in the control group received general anesthesia,while patients in the observation group received low SAPB combined general anesthesia under ultrasound guidance 30 minutes before operation.The perioperative indexes of the two groups were observed and compared,and the visual analogue score (VAS) scores of pain at rest and during cough of patients in the two groups at the time of extubation (T0),4 hours after operation (T1),8 hours after operation (T2),12 hours after operation (T3),and 24 hours after operation (T4) were recorded and compared.The dosage of propofol and remifentanil during operation,the number of analgesic pumps used 24 hours after operation,and the total amount of background infusion were recorded and compared between the two groups.The levels of CRP,IL-6 and PCT were compared between the two groups before operation,1 day after operation and 2 days after operation.The adverse reactions of the two groups were compared as well. 【Results】There was no significant difference between the observation group and the control group in terms of recovery time,extubation time and length of hospitalization (P>0.05).The first time of getting out of bed in the observation group was significantly shorter than that in the control group (P<0.05).At T0,there was no significant difference in VAS scores between the two groups at rest and during cough (P>0.05).The VAS pain scores at T1-T4 in the observation group at rest and during cough were significantly lower than those in the control group (P<0.05).The amount of propofol and remifentanil used during operation,the number of times of pressing analgesia pump 24 hours after operation,and the total amount of background infusion in the observation group were significantly lower than those in the control group (P<0.05).The levels of CRP,IL-6 and PCT in the observation group were significantly lower than those in the control group 1 day and 2 days after operation (P<0.05).The total incidence of adverse reactions in the observation group was significantly lower than that in the control group (P<0.05). 【Conclusion】Compared to general anesthesia,SAPB combined with general anesthesia has a better postoperative analgesic effect on elderly upper abdominal patients.It has less impact on serum CRP,IL-6 and PCT levels,so it can reduce inflammatory reaction and has fewer adverse reactions,which is worthy of clinical application and promotion. 2022 Vol. 39 (11): 1640-1643 [Abstract] ( 46 ) HTML (1 KB)  PDF (1161 KB)  ( 47 ) 1644 Clinical Effect of Warm Nest Pot Combined with Dafelin on PCOS-induced Infertility LI Na, WANG Ying, HU Meng-di DOI: 10.3969/j.issn.1671-7171.2022.11.013 【Objective】To study the effect of warm nest pot combined with dafelin in the treatment of infertility patients with polycystic ovary syndrome (PCOS) and its effect on ovulation rate. 【Methods】A total of 82 PCOS-induced infertile patients admitted to our hospital from July 2019 to July 2021 were recruited in the study. Patients were divided into two groups:the control group was treated with Dafelin, and the observation group was treated with Dafelin plus nest warming pot therapy. The volume of ovaries and the number of follicles in bilateral sinuses were observed before and after treatment. The ovulation rate, pregnancy rate and clinical effective rate of the two groups were compared. The levels of LH, FSH, E2, T and PRL were analyzed before and after treatment. 【Results】After treatment, the volume of ovaries and the number of follicles in bilateral sinuses in the two groups were lower than those before treatment (P<0.05). The volume of ovaries and the number of follicles in bilateral sinuses in the observation group were lower than those in the control group(P<0.05).The ovulation rate, pregnancy rate and total effective rate of the observation group were higher than those of the control group (P<0.05).The levels of LH, T and PRL in the observation group were lower than those in the control group (P<0.05). 【Conclusion】Warm nest pot combined with Dafelin has important clinical value in regulating the sex hormone level of PCOS infertility patients and improving the ovulation rate and pregnancy rate. 2022 Vol. 39 (11): 1644-1646 [Abstract] ( 37 ) HTML (1 KB)  PDF (1133 KB)  ( 19 ) 1647 Effect of Different Doses of Morphine and Propofol Combined with Brachial Plexus Block in Upper Limb Surgery in Children ZHANG Jun, GAO Fei, ZHANG Yu DOI: 10.3969/j.issn.1671-7171.2022.11.014 【Objective】To investigate the effect of different doses of morphine and propofol combined with brachial plexus block in upper limb surgery in children. 【Methods】A total of 122 children who received upper limb surgery in our hospital were randomly divided into two groups with 61 cases in each group. The control group was given 0.05-0.1 mg morphine and 4-12 mg/h propofol,while the observation group was given 0.5 μg/kg morphine and 4-12 mg/h propofol. Brachial plexus block was performed in both groups. The recovery time,recovery time of spontaneous respiration,visual analogue scale (VAS) score,levels of oxygen saturation,heart rate,angiotensin Ⅱ (Ang Ⅱ) and aldosterone (ALD) before surgery (T1),0 horr (T2) and 24 hour (T3) after operation,and anesthetic related adverse reactions were compared between the two groups. 【Results】There was no significant difference in the recovery time of spontaneous breathing and VAS score between the two groups (P>0.05). The surgery recovery time of children in the observation group was shorter than that in the control group (P<0.05). There was no significant difference in oxygen saturation at each time point between the two groups (P>0.05). The heart rates at T2 and T3 in the two groups were lower than those at T1 in the same group; And the heart rate in the observation group was lower than that in the control group (P<0.05). There was no significant difference in the levels of Ang Ⅱ and aldosterone at T1 between the two groups (P>0.05). The levels of Ang Ⅱ and aldosterone at T2 and T3 were higher than those at T1 in the group (P<0.05),and the levels of Ang Ⅱ and aldosterone at T2 and T3 in the observation group were lower than those in the control group on average (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】Low doses morphine and propofol combined with brachial plexus block for upper limb surgery in children can shorten the recovery time,relieve pain,stabilize blood gas indicators,and reduce stress response. Thus,it is safe. 2022 Vol. 39 (11): 1647-1649 [Abstract] ( 34 ) HTML (1 KB)  PDF (1196 KB)  ( 56 ) 1650 Value of Ultrasound Imaging and Laboratory Indexes in Predicting the Risk of Left Atrial Thrombosis in Rheumatic Heart Disease XIAO Wang-li, JIA Bei DOI: 10.3969/j.issn.1671-7171.2022.11.015 【Objective】To explore the value of ultrasonic imaging and laboratory indexes in predicting the risk of left atrial thrombosis in rheumatic heart disease. 【Methods】 The clinical data of 103 patients with rheumatic heart disease admitted to our hospital from August 2020 to August 2021 were analyzed retrospectively. The patients were divided into thrombus group (n=27) and non thrombus group (n=76) according to whether they had left atrial thrombosis. Gender, age, body mass index (BMI), course of disease, hypertension, diabetes, left atrial systolic diameter, left atrial area, left atrial spontaneous echo, activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), fibrinogen (FIB), lysophosphatidic acid (LPA), antithrombin-Ⅲ (AT-Ⅲ) were compared between the two groups. The value of ultrasonic imaging and laboratory indexes in predicting left atrial thrombus in patients with rheumatic heart disease was analyzed by subject operating characteristic curve (ROC); Logistic stepwise regression was used to analyze related risk factors in multivariate analysis. 【Results】The ratio of left atrial systolic diameter, left atrial area, LPA and left atrial spontaneous echo in the thrombosis group was higher than that in the non thrombosis group, while AT-Ⅲ was lower than that in the non thrombosis group (P<0.05). ROC curve analysis showed that the area under the curve of left atrial systolic diameter, left atrial area, LPA, AT-Ⅲ predicting left atrial thrombosis in patients with rheumatic heart disease were 0.851, 0.825, 0.790, 0.844, respectively. Multivariate logistic analysis showed that left atrial systolic diameter ≥ 52.375 mm, left atrial area ≥ 30.480 cm2, left atrial spontaneous echo, LPA ≥ 3.700 μmol/L and AT-Ⅲ≤ 24.985% were risk factors for left atrial thrombosis in patients with rheumatic heart disease (P<0.05). The consistency analysis showed that the sensitivity, specificity and accuracy of predicting left atrial thrombosis in patients with rheumatic heart disease combined with ultrasonic imaging and laboratory indicators were 0.926, 0.961 and 0.951 respectively,Kappa=0.876. 【Conclusion】The combination of ultrasonic imaging and laboratory indexes has a high value in predicting the risk of left atrial thrombosis in rheumatic heart disease, which is conducive to the early diagnosis and treatment of rheumatic heart disease with left atrial thrombosis. 2022 Vol. 39 (11): 1650-1653 [Abstract] ( 32 ) HTML (1 KB)  PDF (1237 KB)  ( 76 ) 1654 Effects of Caveolin-1 and miR-146a on Hemorrhagic Transformation after Intravenous rt-PA Therapy in Patients with Acute Cerebral Infarction LIANG Jia-jia, AN Wei-ying, LI Jing DOI: 10.3969/j.issn.1671-7171.2022.11.016 【Objective】To investigate the effects of plasma caveolin-1 (caveolin-1) and microRNA-146a (miR-146a) on hemorrhagic transformation (HT) after intravenous thrombolytic therapy with recombinant tissue type plasminogen activator (rt-PA) in patients with acute cerebral infarction (ACI). 【Methods】A total of 104 ACI patients who developed HT after intravenous treatment with rt-PA were selected as the HT group,while 536 ACI patients who did not develop HT after intravenous treatment with rt-PA during the same period were selected as the non-HT group.The differences in plasma levels of caveolin-1 and miR-146a between the two groups were analyzed.Pearson method was used to analyze the correlation between the expression levels of plasma caveolin-1 and miR-146a in HT group.Receiver operating characteristic (ROC) curve analysis was applied to analyze the predictive value of plasma caveolin-1 and miR-146a on HT after rt-PA intravenous thrombolysis in ACI patients.The independent influencing factors of HT were analyzed by multivariate logistic regression. 【Results】The expression level of plasma caveolin-1 in the HT group was significantly higher than that in the non-HT group (P<0.05); And the expression level of miR-146a was significantly lower than that in the non-HT group (P<0.05).The miR-146a and caveolin-1 expression levels were negatively correlated in HT group (r=-0.538,P=0.000).The ROC results showed that the areas under the curve of plasma miR-146a and caveolin-1 in predicting HT after rt-PA intravenous thrombolysis in ACI patients were 0.868 and 0.878,respectively,and the areas under the curve predicted by miR-146a combined with caveolin-1 was 0.938.Multivariate regression analysis showed that the history of atrial fibrillation,cardioembolism,high NIHSS score before thrombolysis,long time from onset to thrombolysis,high blood glucose level before thrombolysis,high systolic blood pressure 2 hours after thrombolysis and high plasma caveolin-1 expression level and high expression level of miR-146a were the influencing factors of HT after rt-PA intravenous thrombolysis in ACI patients (P<0.05). 【Conclusion】The abnormal expression of plasma caveolin-1 and miR-146a is closely related to the occurrence of HT after intravenous thrombolysis with rt-PA in ACI patients,and the combined detection of the two can be used to predict the occurrence of HT. 2022 Vol. 39 (11): 1654-1658 [Abstract] ( 43 ) HTML (1 KB)  PDF (1284 KB)  ( 49 ) 1659 Correlation between Fibrinogen/albumin Ratio, D-dimer and Severity of Coronary Artery Disease in Patients with Acute Myocardial Infarction LIU Pei, YUAN Shi-shan, YANG Shuang, et al DOI: 10.3969/j.issn.1671-7171.2022.11.017 【Objective】To investigate the correlation between fibrinogen/albumin ratio (FAR), D-dimer (DD) and the severity of coronary artery disease in patients with acute myocardial infarction (AMI). 【Methods】A total of 201 patients with AMI admitted to our hospital from June 2020 to July 2022 (observation group) were selected, and 80 patients with normal results (control group) who underwent coronary angiography in our hospital at the same time were selected. Multivariate logistic regression was used to analyze the correlation between FAR, DD and AMI. FAR and DD in subgroups of AMI patients were analyzed according to the number of involved diseased branches and the degree of coronary stenosis. The efficacy of FAR and DD in predicting AMI and severe coronary stenosis was evaluated using the receiver operating characteristic (ROC) curve. 【Results】The FAR and DD of patients in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.001).Multivariate logistic regression analysis showed that FAR and DD were risk factors for AMI (P<0.05). The results of different subgroups showed that FAR and DD in the multi vessel disease group were higher than those in the single vessel disease group, and DD in double vessel disease group was higher than that in the single vessel disease group, with significant difference (P<0.05); FAR and DD in the severe stenosis group were higher than those in the mild stenosis group, and DD in the severe stenosis group was higher than that in the moderate stenosis group, with significant difference (P<0.05). The ROC curve results showed that the area under the ROC curve of FAR and DD to predict AMI was 0.721 and 0.71 respectively, and the sensitivity was 80.3% and 87.3% respectively; The area under the ROC curve for predicting severe coronary stenosis was 0.609 and 0.658, respectively, and the specificity was 91.2% and 91.2%, respectively. 【Conclusion】High level FAR and DD are correlated with AMI, and have certain diagnostic value for the severity of coronary artery disease. 2022 Vol. 39 (11): 1659-1661 [Abstract] ( 43 ) HTML (1 KB)  PDF (1333 KB)  ( 50 ) 1662 Expression and Significance of Serum Gastrin, Motilin and Leptin in Patients with Gastroesophageal Reflux after Esophageal Cancer Stent Implantation JIU Meng-na, ZHANG Yi DOI: 10.3969/j.issn.1671-7171.2022.11.018 【Objective】To investigate the expression and significance of serum gastrin (GAS), motilin (MTL) and leptin (LEP) in patients with gastroesophageal reflux after esophageal cancer stent implantation. 【Methods】The clinical data of 214 patients with esophageal cancer who received stent implantation in our hospital from January 2019 to January 2022 were analyzed retrospectively. General data such as serum GAS, MTL and LEP were collected to analyze the occurrence of postoperative gastroesophageal reflux. Single factor and multi factor logistic regression were used to analyze the risk factors of secondary gastroesophageal reflux after esophageal cancer stent implantation. 【Results】Gastroesophageal reflux after esophageal cancer stent implantation was significantly correlated with hyperlipidemia history, low semi sitting position, high sugar and high fat diet, regular drinking of strong tea, moderate exercise, taking NSAIDs, constipation and serum GAS, MTL, LEP (P<0.05). The history of hyperlipidemia, high sugar and high-fat diet, regular drinking of strong tea, taking NSAIDs, constipation, preoperative GAS<108.00 pg/mL, preoperative MTL<213.28 pg/mL, and preoperative LEP ≥ 15.24 ng/mL were independent risk factors for gastroesophageal reflux after esophageal cancer stent implantation (P<0.05); Sleeping posture in low semi sitting position and proper exercise were independent protective factors for postoperative gastroesophageal reflux (P<0.05). 【Conclusion】 The serum GAS, MTL and LEP are closely related to the secondary gastroesophageal reflux after esophageal cancer stent implantation. The abnormal decrease of serum GAS, MTL and the abnormal increase of serum LEP are independent risk factors for the secondary gastroesophageal reflux after esophageal cancer stent implantation, which is worthy of clinical verification. 2022 Vol. 39 (11): 1662-1665 [Abstract] ( 34 ) HTML (1 KB)  PDF (1158 KB)  ( 60 ) 1666 Correlation between Serum NSE, VILIP-1 Levels and NBNA Scores in Neonates with Hypoxic-ischemic Encephalopathy HAN Bo, MOU Chun-yan DOI: 10.3969/j.issn.1671-7171.2022.11.019 【Objective】Objective To investigate the correlation between serum specific neuron enolase (NSE), optic vertebrae protein like protein 1 (VILIP-1) levels and neonatal hypoxic-ischemic encephalopathy (HIE) behavioral neurological score (NBNA). 【Methods】 From March 2018 to August 2021, 126 HIE children (observation group) were selected and 83 healthy newborns (control group) were selected.The levels of serum NSE, VILIP-1 and NBNA scores were compared between the two groups and the observation group at 24 h (T1), 72 h (T2) and 7 d (T3) after birth, and the correlation between the levels of serum NSE, VILIP-1 and NBNA scores was analyzed. At the same time, the diagnostic value of serum NSE, VILIP-1 levels in HIE was analyzed. 【Results】The levels of NSE and VILIP-1 in serum of T1, T2, T3 in the observation group were higher than those in the control group, showing a decreasing trend over time. The NBNA score was lower than that in the control group, showing a rising trend over time, with a statistically significant difference (P<0.05). Compared the serum NSE, VILIP-1 levels and NBNA scores at T1 of children with different disease severity, the serum NSE, VILIP-1 levels showed an upward trend and NBNA scores showed a downward trend with the aggravation of the disease (P<0.05). Pearson correlation coefficient analysis showed that serum NSE, VILIP-1 levels at T1 were negatively correlated with NBNA scores (r=-0.603, -0.589, both P<0.001). The cut-off values of serum NSE and VILIP-1 in diagnosing HIE at T1 were 28.36 μg/L,0.61 μg/L respectively, the area under the curve (AUC) was 0.713 and 0.696 respectively. The AUC, sensitivity and specificity of combined diagnosis of HIE and HIE were higher than that of single diagnosis of HIE and HIE (P<0.05). 【Conclusion】The levels of serum NSE and VILIP-1 are closely related to the NBNA score of HIE children, and dynamic monitoring can guide clinical improvement of treatment. 2022 Vol. 39 (11): 1666-1668 [Abstract] ( 35 ) HTML (1 KB)  PDF (1136 KB)  ( 30 ) 1669 Effect of Ambroxide Combined with Hyperbaric Oxygen on Alexithymia and Hemorheology in Patients with Schizophrenia MIAO Tian-yi, YAN Jun-feng, SU Qi, et al DOI: 10.3969/j.issn.1671-7171.2022.11.020 【Objective】 To investigate the effects of sulfaapride combined with hyperbaric oxygen on alexithymia and hemorheology in patients with schizophrenia. 【Methods】 The clinical data of 118 schizophrenics admitted to Shaanxi Provincial Armed Police Corps Hospital from February 2018 to February 2021 were analyzed retrospectively. They were divided into observation group and control group according to different treatment methods, with 59 cases in each group. The control group was treated with ambroxide, and the observation group was treated with hyperbaric oxygen on the basis of the control group, both of which were treated for 2 months. The curative effect, positive and negative symptom scale (PANSS), simple mental state scale (MMSE), Toronto alexithymia scale (TAS-20) scores, blood rheology indexes (whole blood low shear reduction viscosity, whole blood high shear reduction viscosity, fibrinogen), and adverse reactions were compared between the two groups before and after treatment for 2 months. 【Results】 After 2 months of treatment, the total effective rate in the observation group was 93.22%, which was higher than that in the control group (79.66%, P<0.05); The PANSS and TAS-20 scores in the observation group were lower than those in the control group, and the MMSE scores were higher than those in the control group (P<0.05); The formal level of whole blood low shear reducing viscosity and fibrinogen in the observation group were lower than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups during treatment (P>0.05). 【Conclusion】The combination of ambroxide and hyperbaric oxygen therapy can reduce the positive and negative symptoms, alexithymia, improve cognitive function and hemorheology in patients with schizophrenia, and it is safe and effective. 2022 Vol. 39 (11): 1669-1671 [Abstract] ( 72 ) HTML (1 KB)  PDF (1197 KB)  ( 77 ) 1672 Expression and Clinical Significance of NHERF1 and NF2 in Colorectal Cancer WANG Zhi-wei, ZHANG You-man DOI: 10.3969/j.issn.1671-7171.2022.11.021 【Objective】Objective To investigate the expression and clinical significance of Na+/H+ exchanger regulatory factor 1 (NHERF1) and neurofibrin 2 (NF2) gene in colorectal cancer. 【Methods】 A total of 126 colorectal cancer patients diagnosed and treated in Ankang Central Hospital from March 2015 to June 2016 were selected. Samples of colorectal cancer tissues and normal tissues adjacent to cancer were collected. The positive expression of NHERF1 and NF2 in colorectal cancer tissues and normal tissues adjacent to cancer was detected by immunohistochemistry, and the relationship between the positive expression rate of NHERF1 and NF2 and the clinicopathological characteristics of colorectal cancer patients was analyzed; Cox proportional hazard regression model was used to analyze the prognostic risk factors of colorectal cancer patients. 【Results】The positive expression rate of NHERF1 in colorectal cancer was 74.6%, which was significantly higher than that in normal adjacent tissues (33.3%), and the positive expression rate of NF2 was 28.6%, which was significantly lower than that in normal adjacent tissues (77.8%, P<0.05). The positive rates of NHERF1 and NF2 were not correlated with age and sex (P>0.05); It was correlated with the maximum tumor diameter, TNM stage, depth of invasion, pathological grade, lymph node metastasis and recurrence (P<0.05). The 5-year survival rate of colorectal cancer patients with maximum tumor diameter ≥ 2 cm, TNM stage Ⅲ-Ⅳ, depth of invasion≥1 cm, lymphatic vascular invasion, high pathological grade, recurrence, NHERF1 positive, NF2 negative were significantly reduced (P<0.05). TNM stage Ⅲ-Ⅳ, high pathological grade, positive expression of NHERF1 and negative expression of NF2 were independent risk factors for the prognosis of colorectal cancer patients (P<0.05). 【Conclusion】The positive expression rate of NHERF1 protein in colorectal cancer is increased, while the positive expression of NF2 protein is decreased; NHERF1 positive expression and NF2 negative expression are independent risk factors for prognosis of colorectal cancer patients. 2022 Vol. 39 (11): 1672-1675 [Abstract] ( 39 ) HTML (1 KB)  PDF (1550 KB)  ( 51 ) 1676 Factors of Influencing Efficacy of Maintenance Hemodialysis after CRRT in Severe Lupus Nephritis WANG Zhen-ni, ZHANG Qiang, LUO Lei DOI: 10.3969/j.issn.1671-7171.2022.11.022 【Objective】To investigate the influencing factors of maintenance hemodialysis (MHD) after continuous renal replacement therapy (CRRT) in patients with severe lupus nephritis (LN). 【Methods】A total of 140 patients with severe LN were treated with MHD after CRRT in our hospital. According to the clinical outcome of treatment with MHD for 6 months,patients were divided into the continuous dialysis group (n=57) and the dialysis free group (n=83). General data of patients at the time of enrollment were recorded. Serum creatinine (SCR),blood urea nitrogen (BUN),24-hour urine protein quantification (24hpro),serum complement C3 and C4 levels,and the positive rates of anti-double stranded DNA antibody (anti dsDNA) and anti-nuclear antibody (ANA) of patients in the two groups before MHD treatment were compared. The residual renal function (RRF) and urea clearance rate (Kt/V) of patients within 6 months after MHD treatment were calculated. The predictive indicators and influencing factors of patients who still need to continue dialysis after 6 months of MHD treatment were analyzed. 【Results】There were no significant differences in gender,diabetes mellitus,BUN,serum complement C3 and C4 levels,anti-dsDNA positivity and anti-ANA positive rate between the two groups (P>0.05). The age,Scr and 24hpro levels of the continued dialysis group were significantly higher than those of the free dialysis group,and the RRF and Kt/V were significantly lower than those of the free dialysis group (P<0.05). According to ROC analysis,the areas under the curve of age,Scr,24hpro,RRF and Kt/V in predicting the need for continuing dialysis in patients with severe LN were 0.751,0.651,0.944,0.919 and 0.834,respectively (all P<0.05). Multivariate logistic regression analysis confirmed that age > 57.09 years old,Scr > 461.13 μmol/L,24hpro > 3.405 g/24h,RRF <7.150 mL/min,Kt/V <1.225 were the influencing factors for patients to continue dialysis treatment (P<0.05). 【Conclusion】Age,Scr,24hpro,RRF,Kt/V are the influencing factors for severe LN patients to continue dialysis treatment after CRRT and MHD treatment for 6 months,which deserves clinical attention. 2022 Vol. 39 (11): 1676-1679 [Abstract] ( 28 ) HTML (1 KB)  PDF (1264 KB)  ( 37 ) 1680 Expression of miR-202 in Bladder Cancer Cells and its Effect on Proliferation, Apoptosis and Invasion of Bladder Cancer Cells QIAN Xiong-xian, CHU Jian, ZHAO Yong, et al DOI: 10.3969/j.issn.1671-7171.2022.11.023 【Objective】To investigate the expression of miR-202 in bladder cancer cells and its effect on proliferation, apoptosis and invasion of bladder cancer cells. 【Methods】The relative expression of miR-202 in bladder cells was detected by real-time fluorescence quantitative polymerase chain reaction (qRT-PCR); The miR-202 and miR-NC plasmids were transfected into UM-UC-3 cells by transfection technology and set as miR-202 group and NC group. Cell proliferation test, cell invasion test and apoptosis test were used to detect the proliferation, migration, invasion and apoptosis of cells in the two groups respectively. The volume and weight of transplanted tumors in the two groups were compared. Western blot test was used to detect the expression of PIK3CA protein in the cells of the two groups. 【Results】The relative expression level of miR-202 in bladder cancer cells was lower than that in normal bladder epithelial cells (P<0.05). Compared with NC group, the OD value, migration and number of invasive cells in the miR-202 group decreased, and the apoptosis rate increased, with significant difference (all P<0.05). The volume and weight of transplanted tumor in the miR-202 group were lower than those in the NC group, and the difference was statistically significant. The expression of PIK3CA protein in the miR-202 group was lower than that in the NC group, and the difference was statistically significant. 【Conclusion】miR-202 may inhibit the proliferation, migration, invasion and induce apoptosis of bladder cancer cells by inhibiting the expression of PIK3CA protein. 2022 Vol. 39 (11): 1680-1682 [Abstract] ( 46 ) HTML (1 KB)  PDF (1251 KB)  ( 31 ) 1683 Analysis of Relationship of Preoperative Lower Respiratory Tract Colonization with Postoperative Pulmonary Infection in Patients with Non-small Cell Lung Cancer WANG Li, REN Ming-zhi, JIANG Peng DOI: 10.3969/j.issn.1671-7171.2022.11.024 【Objective】To investigate the relationship of preoperative lower respiratory tract colonization with postoperative pulmonary infection in patients with non-small cell lung cancer (NSCLC). 【Methods】A total of 82 patients with NSCLC who underwent surgery in our hospital from November 2019 to April 2021 were selected as the research subjects. Accorded to the presence or absence of airway colonized pathogen/bacteria in the lower respiratory tract before surgery, they were divided into groups with airway colonization group and non-airway colonization group.The postoperative pulmonary complications of the two groups were compared. The distribution of pathogenic bacteria in patients with lung infection after operation was analyzed. The clinical data of patients with lung infection and uninfected lungs after surgery were compared. Logistic multivariate regression analysis of influencing risk factors of postoperative lung infection in NSCLC patients was analyzed. 【Results】There was no statistically significant difference in the incidence of subcutaneous emphysema, pulmonary embolism, hoarseness, and chylothorax between the airway colonized bacteria group and the non-airway colonized bacteria group (P>0.05). The incidence of pulmonary infection in the airway colonized bacteria group was 25.00%, which was higher than that in the non-airway bacteria group 5.26% (P<0.05). Among 13 patients with lung infections, 23 strains were detected. Of which, gram-negative bacteria, gram-positive bacteria and fungi accounted for 56.52%, 39.13%, and 4.35% of the total number of pathogens, respectively. The proportion of postoperative lung infection patients with smoking history, white blood cell count (WBC), operation time, hospital stay, invasive procedures, and preoperative airway colonized bacteria were higher than those of patients without lung infection (P<0.05). Logistic regression analysis showed that invasive operations and preoperative airway colonization bacteria were risk factors for postoperative lung infection in NSCLC patients (OR=2.852, 3.425, P<0.05). 【Conclusion】Preoperative airway colonized pathogen/bacteria in the lower respiratory tract of NSCLC patients increases the incidence of postoperative lung infection. Invasive procedures and preoperative airway with colonized bacteria are risk factors for postoperative lung infection in NSCLC patients. Attention should be paid to strengthen precautions in clinical practice. 2022 Vol. 39 (11): 1683-1686 [Abstract] ( 38 ) HTML (1 KB)  PDF (1162 KB)  ( 47 ) 1687 Effect of Minimally Invasive Transforaminal Lumbar Interbody Fusion on Adjacent Segment Intrusion and Postoperative Imaging Degeneration of Adjacent Segment Disorder CHEN Zhi-hui, SUN Peng-cheng, WANG Guo-zhu, et al DOI: 10.3969/j.issn.1671-7171.2022.11.025 【Objective】To investigate the effects of in minimally invasive transforaminal lumbar interbody fusion (MIS-TLIIF) on the intrusion of adjacent segments and postoperative imaging degeneration of adjacent segments disorder (ASDed). 【Methods】A total of 185 patients with single-segment degenerative lumbar spine disease treated with MIS-TLIIF in our hospital were enrolled in the syudy.Three months after surgery,the incidence of intrusion of the adjacent joint facet joints was counted.Patients were divided into the intrusive group and the non-intrusive group according to whether the adjacent segmental facet joints were invaded.The related factors affecting the intrusion of adjacent segmental facet joints after MIS-TLIIF were analyzed.After 3 years of follow-up,the incidence of ASDed after the operation was compared between the intrusive group and the non-intrusive group. 【Results】Three months after surgery,64 cases of adjacent segmental facet joint intrusion occurred,the incidence was 34.59%,while 121 cases were not disturbed.In the intrusion group,body mass index (BMI) ≥30 kg/m2,apical vertebral segment of L5,preoperative facet joint angle ≥40°,facet joint axial diameter,coronal diameter and sagittal of the shape diameter were higher than those of the non-intrusive group (P＜0.05).The preoperative screw inclination angle and the distance between nut and superior articular process in the intrusion group were lower than those in the non-intrusion group (P＜0.05). Logistic multivariate regression analysis showed that the apical vertebral segment of L5,BMI≥30 kg/m2,and preoperative facet joint angle ≥40° were all influencing factors for the intrusion of the adjacent segmental facet joint after MIS-TLIIF (P＜0.05).After 3 years of follow-up,2 cases in the intrusion group and 4 cases in the non-intrusion group were lost to folloe-up.The follow-up rate was 96.76%.The incidence of ASDed in the intrusion group (56.45%) was higher than that in the non-intrusion group (39.32%,P<0.05). 【Conclusion】The apical vertebral segment of L5,BMI≥30 kg/m2 and preoperative facet joint angle ≥40° are the influencing factors of the adjacent segmental facet joint invasion after MIS-TLIIF.And Patients with the adjacent segmental facet joint invasion after MIS-TLIIF have a higher risk of ASDed within 3 years after surgery. 2022 Vol. 39 (11): 1687-1690 [Abstract] ( 48 ) HTML (1 KB)  PDF (1160 KB)  ( 57 ) 1691 Effect of Canal Wall Up Mastoidectomy on Hearing and Quality of Life of Patients with Middle Ear Cholesteatoma LUO Zhen-feng, YANG Hang, LI Heng DOI: 10.3969/j.issn.1671-7171.2022.11.026 【Objective】To investigate the effect of canal wall up mastoidectomy (CWUM) on hearing and quality of life of patients with middle ear cholesteatoma (MEC). 【Methods】A total of 80 MEC patients admitted to Ankang Certral Hospital from August 2018 to August 2021 were selected and divided into observation group and control group according to different treatment methods, with 40 patients in each group. The observation group was treated with CWUM, and the control group was treated with open tympanoplasty. The clinical efficacy, hospitalization time, hearing improvement time, effusion disappearance time, operation cost, preoperative and postoperative quality of life, pure tone test results of the two groups were compared. 【Results】The total effective rate of the observation group was 95.00%, which was significantly higher than that of the control group (77.50%, P<0.05); The time of hospitalization, hearing improvement and effusion disappearance in the observation group were shorter than those in the control group (P<0.05);The improvement of air conduction (AC), bone conduction (BC) and air-bone gap (ABG) in the observation group after operation was better than that before operation and after operation in the control group (P<0.05); The scores of physical symptoms, utilization of medical resources, emotional disorder and life restriction in the observation group were higher than those before and after the operation in the control group (P<0.05). 【Conclusion】 CWUM treatment of MEC can significantly shorten the hospitalization time, improve the hearing of patients, and improve the clinical efficacy and quality of life of patients. 2022 Vol. 39 (11): 1691-1693 [Abstract] ( 35 ) HTML (1 KB)  PDF (1191 KB)  ( 95 ) 1694 Relationship of Keratin 7 and P53 Protein with Clinicopathological Diagnosis and Recurrence Risk of Bladder Cancer FANG Xin-yan, GU Ying-hui, SHI Yan-lin DOI: 10.3969/j.issn.1671-7171.2022.11.027 【Objective】 To investigate the correlation of keratin 7 (KRT7) and p53 protein with clinicopathological features and recurrence prediction of bladder cancer. 【Methods】The clinical data of 72 patients with bladder cancer in our hospital were retrospectively analyzed. The expression of KRT7 and p53 protein was measured by immunohistochemical staining,The positive rates of KRT7 and p53 protein in cancer tissues and adjacent tissues were compared between the two groups. The positive rates of KRT7 and p53 protein in different clinical and pathological characteristics were compared as well. The recurrence rate of 3 cases of bladder cancer patients with different expressions of KRT7 and p53 protein was observed. 【Results】The positive rate of KRT7 in cancer tissues was significantly lower than that in adjacent tissues,while the positive rate of p53 protein was significantly higher than that in adjacent tissues (P<0.05).The negative detection rate of KRT7 and the positive detection rate of p53 protein were significantly higher in patients with capsule infiltration,medium-poor differentiation and lymph node metastasis (P<0.05).The 3-year recurrence rates of patients with KRT7 negative and p53 positive bladder cancer were 46.15% and 50.00%,respectively,which were higher than those of KRT7 positive and p53 negative patients. The recurrence rate was 12.12% and 15.00%,the difference was statistically significant (Log-Rank=17.553,12.281,P<0.05). 【Conclusion】p53 protein was highly expressed in bladder cancer tissues,while KRT7 was lowly expressed. The expression level was closely related to histological differentiation,lymph node metastasis and infiltration of membrane. 2022 Vol. 39 (11): 1694-1697 [Abstract] ( 53 ) HTML (1 KB)  PDF (1236 KB)  ( 49 ) 1698 Clinical Study of Qingre Liangxue Decoction Combined with NB-UVB in Treating Vitiligo with Blood Deficiency and Wind-heat Type ZHANG Xia, LEI Ya-li DOI: 10.3969/j.issn.1671-7171.2022.11.028 【Objective】To explore the clinical value of Qingre Liangxue Decoction combined with narrow-band ultraviolet (NB-UVB) in the treatment of vitiligo showing blood deficiency and wind-heat type. 【Methods】 A total of 90 patients with vitiligo who visited Yangling Demonstration Area Hospital dermatology clinic from January 2017 to September 2021 were selected as the study subjects. Patients were divided into the observation group and the control group according to the random number table method, with 45 cases in each group. Patients in the control group were treated with NB-UVB, and patients in the observation group were treated with Qingre liangxue Decoction on the basis of the control group. The treatment period of both groups was 6 weeks. The treatment effects and adverse reactions during the treatment were compared between the two groups of patients. The scores of TCM syndromes, CXC chemokine ligand 16 (CXCL16), transforming growth factor-β1 (TGF-β1), Interleukin-26 (IL-26) and T lymphocytes (CD4+, CD8+ and CD4+/CD8+) were compared between the two groups before and after treatment. 【Results】The total effective rate of the observation group was 93.33%, which was significantly higher than that of the control group 77.78% (P<0.05).The scores of local leukoplakia, pale complexion, loss of appetite, dizziness, palpitations, insomnia, and fatigue after treatment in the two groups were significantly lower than those before treatment (P<0.05).After treatment, the observation group's local leukoplakia, pale complexion, loss of appetite, dizziness, palpitations, insomnia, and fatigue scores were significantly lower than those of the control group (P<0.05).The levels of CXCL16, TGF-β1 and IL-26 after treatment in the two groups were significantly lower than those before treatment (P<0.05). After treatment, levels of CXCL16, TGF-β1, and IL-26 in the observation group were significantly lower than those in the control group (P<0.05). CD4+, CD4+/CD8+ after treatment in the two groups were significantly higher than those before treatment, while CD8+ was significantly lower than before treatment (P<0.05).After treatment, CD4+, CD4+/CD8+ in the observation group were significantly higher than those in the control group, while CD8+ in the observation group was significantly lower than that in the control group (P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups during treatment (P>0.05). 【Conclusion】The combination of Qingre Liangxue Decoction and NB-UVB has a good therapeutic effect in the treatment of blood deficiency and wind-heat type vitiligo. It can effectively relieve the patient's clinical symptoms, inhibit inflammation, regulate immune function, and has good safety. 2022 Vol. 39 (11): 1698-1701 [Abstract] ( 37 ) HTML (1 KB)  PDF (1159 KB)  ( 52 ) 1702 Relationship of Serum Endothelin, Leptin and Vaspin Levels with Insulin Resistance in Gestational Diabetes Mellitus Patients YU Meng-chun, DU Yuan-yuan DOI: 10.3969/j.issn.1671-7171.2022.11.029 【Objective】To investigate the correlation of serum endothelin, leptin and vaspin (visceral adipose tissue-derived serine protease inhibitor) with insulin resistance in gestational diabetes mellitus. 【Methods】A total of 352 pregnant women who had regular prenatal examination in the Affiliated Hospital of Yan'an University from June 2014 to June 2019 were selected in the study. According to the results of oral 75 g glucose tolerance test (OGTT), patients were divided into the gestational diabetes mellitus group (GDM, n=126) and the control group with non-GDM (n=126) by. Serum endothelin level was measured by radioimmunoassay, serum leptin and vaspin levels were detected by enzyme-linked immunosorbent assay (ELISA), blood glucose and lipid routine indices were measured and the insulin resistance index (HOMA-IR) was calculated. The relationship of endothelin, leptin and vaspin with blood glucose and lipid was analyzed. 【Results】The levels of systolic blood pressure(SBP), fasting blood glucose(FPG), glycosylated hemoglobin(HbAlc), triacylglycerol(TG), low-density lipoprotein cholesterol(LDL-C), fasting insulin(FINS), HOMA-IR, serum endothelin, leptin and vaspin in gestational diabetes mellitus group were significantly higher than those in the control group (all P<0.05). Serum endothelin level in gestational diabetes mellitus patients was positively correlated with FPG, HbAlc, FINS and HOMA-IR levels (P<0.05); Leptin level was positively correlated with FPG, TG, HbAlc, FINS and HOMA-IR levels (P<0.05); And vaspin level was positively correlated with FPG, TG, FINS and HOMA-IR levels (P<0.05). High levels of FINS, endothelin, HOMA-IR, leptin and vaspin were risk factors for gestational diabetes mellitus (all P<0.05). 【Conclusion】The levels of HOMA-IR, serum endothelin, leptin and vaspin in patients with gestational diabetes mellitus are significantly higher than those in the control group. Levels of serum endothelin, leptin and vaspin are positively correlated with the level of HOMA-IR, which may affect the occurrence and development of gestational diabetes mellitus together. 2022 Vol. 39 (11): 1702-1704 [Abstract] ( 37 ) HTML (1 KB)  PDF (1140 KB)  ( 22 ) 1705 Application Value of Electrophysiological Technology Based on the Concept of Rapid Rehabilitation in Patient Rehabilitation after Hysterectomy WANG Lei-yuan, YANG Chu, XIAN Hong-mei DOI: 10.3969/j.issn.1671-7171.2022.11.030 【Objective】To explore the value of elect rophysiological techniques based on the concept of rapid rehabilitation in postoperative rehabilitation of patients undergoing hysterectomy. 【Methods】A total of 108 patients with hysterectomy who were treated in our hospital from September 2019 to July 2020 were selected and divided into the control group and the observation group according to the random number table method, with 54 cases in each group. The control group was treated with routine accelerated rehabilitation nursing, while the observation group was treated with electrophysiological technology based on the concept of rapid rehabilitation. The abdominal distension and abdominal pain were compared between the two groups at 3 days after operation, 15 days after operation, and 100 days after operation. The time of bowel sound recovery, anal exhaust time and defecation time were compared as well. 【Results】The degree of abdominal distension and abdominal pain in the observation group was significantly lower than that in the control group at 15 d and 100 d after operation (P<0.05). After operation, the recovery time of bowel sounds, anal exhaust time and defecation time in the observation group were shorter than those in the control group (P<0.05). 【Conclusion】Electrophysiological techniques based on the concept of rapid rehabilitation can reduce the degree of abdominal distension and pain during hysterectomy and provide help for the recovery of digestive function. 2022 Vol. 39 (11): 1705-1707 [Abstract] ( 39 ) HTML (1 KB)  PDF (1187 KB)  ( 73 ) 1708 Correlation between Plasma miR-26b Level and Coronary Artery Injury in Children with Kawasaki Disease ZHU Qi-fei, SUN Feng DOI: 10.3969/j.issn.1671-7171.2022.11.031 【Objective】 To investigate the relationship between plasma microRNA-26b (miR-26b) and coronary artery injury in children with Kawasaki disease. 【Methods】 A total of 106 children with Kawasaki disease admitted to our hospital from February 2018 to July 2020 (observation group) were selected and divided into injury group (n=34) and non injury group (n=72) according to the condition of coronary artery injury. At the same time, 110 healthy children in the same period were selected as the control group. The expression level of miR-26b in plasma was detected by real-time fluorescence quantitative polymerase chain reaction (qRT-PCR), and the relationship between miR-26b and vascular diameter in plasma of patients was analyzed by Pearson;The predictive value of miR-26b level in plasma for coronary artery injury in children with Kawasaki disease was analyzed by drawing the receiver operating characteristic (ROC) curve. 【Results】 The expression level of miR-26b in plasma of the observation group was 0.69 ± 0.12, which was significantly higher than that of the control group (1.02 ± 0.16), and the difference was statistically significant (t=17.10, P<0.05). Pearson correlation analysis showed that there was a correlation between miR-26b in plasma and vessel diameter in the diseased group. The results showed that there was a negative correlation between miR-26b in plasma and vessel diameter (r=-0.410, P<0.05). The ROC curve showed that the area under the ROC curve of plasma miR-26b level predicting coronary artery injury in children with Kawasaki disease was 0.807 (95%CI:0.724~0.890), the cut-off value was 0.69, the sensitivity was 85.30%, and the specificity was 70.80%. 【Conclusion】 The expression of miR-26b in plasma is low in children with Kawasaki disease, and the level of miR-26b is lower in children with coronary artery injury in Kawasaki disease, which is negatively related to the diameter of blood vessels. The plasma miR-26b has certain value in predicting coronary artery injury. 2022 Vol. 39 (11): 1708-1711 [Abstract] ( 39 ) HTML (1 KB)  PDF (1176 KB)  ( 21 ) 1712 Effects of Glucocorticoid Combined with Vestibular Function Training on Balance Function and Oxidative Stress in Patients with Vestibular Neuritis LI Jin, ZOU Xing-ju DOI: 10.3969/j.issn.1671-7171.2022.11.032 【Objective】To explore the effects of glucocorticoid combined with vestibular function training on the balance function,levels of inflammatory factors and oxidative stress in patients with vestibular neuritis. 【Methods】A total of 70 patients with vestibular neuritis who were diagnosed and treated in our hospitals were divided into the observation group (n=35 cases) and the control group (n=35 cases).The patients in the control group received vestibular function training only,while patients in the observation group were treated with prednisone tablets in addition to vestibular function training.The treatment contained 2 consecutive courses of 2-week treatment per course.The score of Berg Balance Scale (BBS),the levels of inflammatory factors interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α),the levels of malondialdehyde (MDA) and superoxide dismutase (SOD),the markers of oxidative stress before and after treatment,and the clinical effects were observed and compared between the two groups before and after treatment. 【Results】After treatment,the BBS score and the level of serum SOD in the two groups were higher than before treatment (P<0.05).And those parameters of patients in the observation group were significantly higher than those of patients in the control group (P<0.05).Levels of serum TNF-α,IL-6 and MDA in the two groups after treatment were lower than those before treatment (P<0.05).Patients in the observation group showed significantly lower levels of TNF-α,IL-6 and MDA compared to patients in the control group (P<0.05).After treatment,the total effective rate of the observation group was higher than that the control group (P<0.05). 【Conclusion】Glucocorticoid combined with vestibular function training can improve the balance function of patients with vestibular neuritis,reduce the level of inflammatory factors,improve the level of oxidative stress,and improve the clinical efficacy. 2022 Vol. 39 (11): 1712-1714 [Abstract] ( 34 ) HTML (1 KB)  PDF (1133 KB)  ( 46 )

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