|
|
|
| Effects of Dexmedetomidine on Analgesic Effect,Inflammatory Factors and T Lymphocyte Subsets in Patients undergoing TACE Operation for Primary Liver Cancer |
| LI Jie, ZHANG Yu-he, LI Wei, et al |
| Yan 'an University Xianyang Hospital,Xianyang Shaanxi 712000 |
|
|
|
|
Abstract 【Objective】To investigate the effect of dexmedetomidine on the analgesic effect,inflammatory factors and T lymphocyte subsets of patients undergoing percutaneous transhepatic arterial chemoembolization (TACE) for primary liver cancer. 【Methods】A total of 72 patients with primary liver cancer who were to be treated with TACE were randomly divided into the control group (administration of hydromorphone hydrochloride + tropisetron + saline) and the observation group (administration of hydromorphone hydrochloride + tropisetron + dexmedetomidine),each group had 36 cases of patients.The levels of visual pain simulation score (VAS),inflammatory factors and T lymphocyte subsets were compared between the two groups.Adverse reactions in the two groups of patients during the perioperative period were compared as well. 【Results】There was no significant difference in VAS scores between the two groups of patients before operation (P>0.05).The VAS scores of the two groups of patients at 6 h,12 h and 24 h after surgery were higher than those before surgery (P<0.05).The VAS scores of the observation group at 6 h,12 h and 24 h after operation were lower than those of the control group (P<0.05).At 24 h after surgery,the levels of IFN-γ and TGF-β in the two groups decreased (P<0.05).The levels of IFN-γ and TGF-β at 24 h in the observation group were lower than those in the control group (P<0.05).Compared with preoperatively,serum CD3+,CD4+,CD8+,CD4+/CD8+ ratio all decreased (P<0.05).The CD3+,CD4+,and CD4+/CD8+ ratio of the observation group were higher than those of the control group at 24 h after the operation (P<0.05).There was no difference in the CD8+ levels of the two groups at 24 h after the operation.Statistical significance (P>0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups of patients (P>0.05). 【Conclusion】Dexmedetomidine has a better analgesic effect on patients undergoing TACE for primary liver cancer,which can regulate the level of inflammatory factors and improve the patient's immune function.It is safe and reliable.
|
|
Received: 25 January 2022
|
|
|
|
|
|
[1] ARSLAN M,DEGIMENCIOGLU S.Risk factors for postembolization syndrome after transcatheter arterial chemoembolization[J].Curr Med Imaging Rev,2019,15(4):380-385.
[2] 顾星石,白旭明,程龙,等.经皮微波消融术前采用肝动脉化疗栓塞术对老年肝癌的临床疗效分析[J].中华老年医学杂志,2019,38(8):885-888.
[3] 杨学刚,吴戈,何乾文,等.吗啡注射液复合右美托咪定在肝动脉灌注化疗栓塞治疗肝癌术中的应用[J].介入放射学杂志,2019,28(8):738-741.
[4] 中国抗癌协会肝癌专业委员会.原发性肝癌规范化病理诊断指南(2015年版)[J].中华肝胆外科杂志,2015,31(6):833-839.
[5] FAIZ K W.VAS-visual analog scale[J].Tidsskr Nor Laegeforen,2014,134(3):323.
[6] TAYLOR A C,MADDIRELA D,WHITE S B.Role of radioembolization for biliary tract and primary liver cancer[J].Surg Oncol Clin N Am,2019,28(4):731-743.
[7] 邓林,孙文杰,高知玲,等.中晚期原发性肝癌患者TACE术后早期复发危险因素[J].中国介入影像与治疗学,2020,17(2):65-69.
[8] LU H,ZHENG C,LIANG B,et al.Efficacy and safety analysis of dexamethasone-lipiodol emulsion in prevention of post-embolization syndrome after TACE:a retrospective analysis[J].BMC Gastroenterol,2021,21(1):256.
[9] 赵闯,梁超,董宝剑,等.原发性肝癌患者接受TACE术时行右美托咪定联合吗啡麻醉临床应用价值分析[J].实用肝脏病杂志,2021,24(2):4-6.
[10] CHEN P,LUO X,DAI G,et al.Dexmedetomidine promotes the progression of hepatocellular carcinoma through hepatic stellate cell activation[J].Exp Mol Med,2020,52(7):1062-1074.
[11] 司海超,司小萌,张新科,等.盐酸右美托咪定对肺癌患者术后镇痛效果及机体免疫功能的影响[J].癌症进展,2019,17(7):808-811. |
| [1] |
. [J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(9): 1412-1414. |
|
|
|
|
2022, Vol. 39 
